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    The distribution of different phosphoinositides in a multinuclear osteoclast is revealed by the localizations of GFP-AktPH (green) and RFP-PLCδ1PH (red). AktPH binds the phosphoinositides PtdIns(3,4)P2 and PtdIns (3,4,5)P3 , which are enriched in podosome-associated membrane protrusions that promote the fusion of osteoclast precursors.
    Image courtesy of Tsukasa Oikawa.
    See page 553.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

An in vivo study reveals how an miRNA family inhibits osteoblast proliferation and differentiation.

People & Ideas

Camargo studies the regulation of organ size and the biology of adult stem cells.



Mutation of a critical residue of fascin eliminates the protein’s actin-bundling activity but maintains its positive role in filopodia formation

Reduced Drp1-mediated mitochondrial fission decreases cell cycle exit and prevents Notch-dependent follicle cell differentiation during oogenesis.

Simultaneous ion conductance and confocal microscopy in live cells reveal a new form of asymmetric clathrin-coated pit closure.


miR-34b and -c inhibit osteoblast proliferation and differentiation by decreasing the levels of cell cycle proteins and of the nuclear matrix protein SATB2.

Stoichiometry determined in this study suggests that the fully loaded and assembled Tat translocase is an ∼2.2-megadalton complex that can individually transport eight precursor proteins or cooperatively transport multimeric precursors.

Mitochondrial division serves as a quality control mechanism to suppress oxidative damage and thus promote neuronal survival.

Tks5, a master regulator of invadopodia in cancer cells, is also crucial for osteoclast cell–cell fusion.

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