On the cover
Inoko et al. reveal that the centriolar protein trichoplein activates Aurora A kinase to suppress the assembly of primary cilia in proliferating cells. Proliferating RPE1 cells (with nuclei labeled in blue) lacking trichoplein aberrantly form primary cilia (which are stained for acetylated tubulin, green) and undergo cell cycle arrest.
Image courtesy of Akihito Inoko.
See page 391.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
People & Ideas
Trim39 inhibits the ability of APC/CCdh1 to ubiquitylate and promote the degradation of MOAP-1, leading to enhanced apoptosis.
An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component
Promiscuous interactions of the intrinsically disordered Rnq1 prion protein with the spindle pole body component Spc42 result in Spc42’s sequestration in insoluble bodies and cell cycle arrest.
Keratin 6 negatively regulates Src kinase activity and the migratory potential of skin keratinocytes during wound repair.
The trichoplein–AurA pathway must suppress primary cilia assembly in order for cells to exit G1.
A novel MVB/lysosomal sorting pathway for signaling receptors bypasses the requirement for ubiquitination and ubiquitin-binding ESCRTs and may be broadly applicable to GPCRs containing YPXnL motifs.
Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition
The focal adhesion protein Hic-5 acts through RhoC to promote TGF-β–stimulated invadopodia formation, cell migration, and invasion.
The elastic behavior of the 3D extracellular matrix determines the relative polarization of intracellular signaling and whether cells migrate using lamellipodia or lobopodia.