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Study identifies a centriolar protein that activates Aurora A to suppress ciliogenesis in proliferating cells.

People & Ideas

Murphy studies reproductive and cognitive aging in C. elegans.




Trim39 inhibits the ability of APC/CCdh1 to ubiquitylate and promote the degradation of MOAP-1, leading to enhanced apoptosis.

Promiscuous interactions of the intrinsically disordered Rnq1 prion protein with the spindle pole body component Spc42 result in Spc42’s sequestration in insoluble bodies and cell cycle arrest.

Keratin 6 negatively regulates Src kinase activity and the migratory potential of skin keratinocytes during wound repair.


The trichoplein–AurA pathway must suppress primary cilia assembly in order for cells to exit G1.

A novel MVB/lysosomal sorting pathway for signaling receptors bypasses the requirement for ubiquitination and ubiquitin-binding ESCRTs and may be broadly applicable to GPCRs containing YPXnL motifs.

The focal adhesion protein Hic-5 acts through RhoC to promote TGF-β–stimulated invadopodia formation, cell migration, and invasion.

The elastic behavior of the 3D extracellular matrix determines the relative polarization of intracellular signaling and whether cells migrate using lamellipodia or lobopodia.


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