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    Inoko et al. reveal that the centriolar protein trichoplein activates Aurora A kinase to suppress the assembly of primary cilia in proliferating cells. Proliferating RPE1 cells (with nuclei labeled in blue) lacking trichoplein aberrantly form primary cilia (which are stained for acetylated tubulin, green) and undergo cell cycle arrest.
    Image courtesy of Akihito Inoko.
    See page 391.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study identifies a centriolar protein that activates Aurora A to suppress ciliogenesis in proliferating cells.

People & Ideas

Murphy studies reproductive and cognitive aging in C. elegans.




Trim39 inhibits the ability of APC/CCdh1 to ubiquitylate and promote the degradation of MOAP-1, leading to enhanced apoptosis.

Promiscuous interactions of the intrinsically disordered Rnq1 prion protein with the spindle pole body component Spc42 result in Spc42’s sequestration in insoluble bodies and cell cycle arrest.

Keratin 6 negatively regulates Src kinase activity and the migratory potential of skin keratinocytes during wound repair.


The trichoplein–AurA pathway must suppress primary cilia assembly in order for cells to exit G1.

A novel MVB/lysosomal sorting pathway for signaling receptors bypasses the requirement for ubiquitination and ubiquitin-binding ESCRTs and may be broadly applicable to GPCRs containing YPXnL motifs.

The focal adhesion protein Hic-5 acts through RhoC to promote TGF-β–stimulated invadopodia formation, cell migration, and invasion.

The elastic behavior of the 3D extracellular matrix determines the relative polarization of intracellular signaling and whether cells migrate using lamellipodia or lobopodia.


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