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Cover Image
Cover Image
On the cover
Inoko et al. reveal that the centriolar protein trichoplein activates Aurora A kinase to suppress the assembly of primary cilia in proliferating cells. Proliferating RPE1 cells (with nuclei labeled in blue) lacking trichoplein aberrantly form primary cilia (which are stained for acetylated tubulin, green) and undergo cell cycle arrest.
Image courtesy of Akihito Inoko.
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In This Issue
In Focus
Trichoplein keeps primary cilia silent
Study identifies a centriolar protein that activates Aurora A to suppress ciliogenesis in proliferating cells.
People & Ideas
Coleen Murphy: How to stay young at heart, body, and mind
Murphy studies reproductive and cognitive aging in C. elegans.
Editorial
Review
Report
The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1
Trim39 inhibits the ability of APC/CCdh1 to ubiquitylate and promote the degradation of MOAP-1, leading to enhanced apoptosis.
An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component
Promiscuous interactions of the intrinsically disordered Rnq1 prion protein with the spindle pole body component Spc42 result in Spc42’s sequestration in insoluble bodies and cell cycle arrest.
A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair
Keratin 6 negatively regulates Src kinase activity and the migratory potential of skin keratinocytes during wound repair.
Article
Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells
The trichoplein–AurA pathway must suppress primary cilia assembly in order for cells to exit G1.
ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting
A novel MVB/lysosomal sorting pathway for signaling receptors bypasses the requirement for ubiquitination and ubiquitin-binding ESCRTs and may be broadly applicable to GPCRs containing YPXnL motifs.
Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition
The focal adhesion protein Hic-5 acts through RhoC to promote TGF-β–stimulated invadopodia formation, cell migration, and invasion.
Nonpolarized signaling reveals two distinct modes of 3D cell migration
The elastic behavior of the 3D extracellular matrix determines the relative polarization of intracellular signaling and whether cells migrate using lamellipodia or lobopodia.
