In This Issue
People & Ideas
PLK1-mediated phosphorylation of pericentrin induces proper organization of the spindle pole–specific pericentriolar matrix and subsequent centrosome maturation.
Aurora A and Aurora B have nonredundant functions during mitosis in chromosome segregation and anaphase microtubule dynamics.
Formation of a Protocadherin-19–N-cadherin complex facilitates adhesion by Protocadherin-19 while suppressing homophilic interactions by N-cadherin.
The Cdc6 replication licensing factor acts as a molecular switch at the E-cadherin locus, leading to E-cadherin transcriptional repression and local activation of replication.
S-foci, the first reported mRNA-silencing foci specific to neurons, may control local mRNA translation in response to NMDA receptor stimulation and synaptic plasticity.
In vitro reconstitution fusion assays incorporating full-length membrane-anchored synaptotagmin I clarify its role in several steps in the secretory pathway.
Neuregulin/ErbB signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of α-dystrobrevin1.
Desmogleins and desmocollins are transported to the plasma membrane by different kinesin motors, providing a potential mechanism to tailor desmosome structure and function during development and epithelial remodeling.