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Cover Image
Cover Image
On the cover
A 3D-rendered time-lapse series shows the disassembly of the mitotic spindle (orange) after inactivation of the cyclindependent kinase Cdk1. Hégarat et al. reveal that spindle microtubules are stabilized in the absence of Aurora A and Aurora B activity, indicating that these two mitotic kinases regulate anaphase microtubule dynamics. Image courtesy of Nadia Hégarat and Helfrid Hochegger.
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In This Issue
In Focus
Neuregulins show their support for neuromuscular junctions
Proteins help establish a solid foundation for nerve–muscle connections.
People & Ideas
Rong Li: Tipping the balance in cell biology
Li takes multiple approaches to understand how signaling pathways really work.
Review
Report
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis
PLK1-mediated phosphorylation of pericentrin induces proper organization of the spindle pole–specific pericentriolar matrix and subsequent centrosome maturation.
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics
Aurora A and Aurora B have nonredundant functions during mitosis in chromosome segregation and anaphase microtubule dynamics.
A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion
Formation of a Protocadherin-19–N-cadherin complex facilitates adhesion by Protocadherin-19 while suppressing homophilic interactions by N-cadherin.
Article
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins
The Cdc6 replication licensing factor acts as a molecular switch at the E-cadherin locus, leading to E-cadherin transcriptional repression and local activation of replication.
Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation
S-foci, the first reported mRNA-silencing foci specific to neurons, may control local mRNA translation in response to NMDA receptor stimulation and synaptic plasticity.
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion
In vitro reconstitution fusion assays incorporating full-length membrane-anchored synaptotagmin I clarify its role in several steps in the secretory pathway.
Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin
Neuregulin/ErbB signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of α-dystrobrevin1.
Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes
Desmogleins and desmocollins are transported to the plasma membrane by different kinesin motors, providing a potential mechanism to tailor desmosome structure and function during development and epithelial remodeling.
