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In Focus

Proteins help establish a solid foundation for nerve–muscle connections.

People & Ideas

Li takes multiple approaches to understand how signaling pathways really work.


Host–pathogen interactions
Host–pathogen interactions


PLK1-mediated phosphorylation of pericentrin induces proper organization of the spindle pole–specific pericentriolar matrix and subsequent centrosome maturation.

Aurora A and Aurora B have nonredundant functions during mitosis in chromosome segregation and anaphase microtubule dynamics.

Formation of a Protocadherin-19–N-cadherin complex facilitates adhesion by Protocadherin-19 while suppressing homophilic interactions by N-cadherin.


The Cdc6 replication licensing factor acts as a molecular switch at the E-cadherin locus, leading to E-cadherin transcriptional repression and local activation of replication.

S-foci, the first reported mRNA-silencing foci specific to neurons, may control local mRNA translation in response to NMDA receptor stimulation and synaptic plasticity.

In vitro reconstitution fusion assays incorporating full-length membrane-anchored synaptotagmin I clarify its role in several steps in the secretory pathway.

Neuregulin/ErbB signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of α-dystrobrevin1.

Desmogleins and desmocollins are transported to the plasma membrane by different kinesin motors, providing a potential mechanism to tailor desmosome structure and function during development and epithelial remodeling.


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