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Cover Image
Cover Image
On the cover
Gong et al. reveal that the adipocyte protein Fsp27 (green) concentrates at the sites of contact between lipid droplets (red), where it promotes the growth of these fat-storing organelles by facilitating lipid transfer. Image courtesy of Zhiqi Sun.
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In This Issue
In Focus
Shs1 rounds out the septin repertoire
Study reveals how changes in subunit composition and phosphorylation alter the organization of septin filaments.
People & Ideas
Michael Overholtzer: Answering existential questions on entosis
Overholtzer is working to understand how and why tumor cells invade one another.
Review
Cell death and infection: A double-edged sword for host and pathogen survival
Report
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
The lipid droplet–associated protein Fsp27 mediates lipid droplet growth by promoting directional lipid transfer from smaller to larger lipid droplets.
Article
Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers
The yeast Kes1p/Osh4p protein functions as a sterol/PI(4)P exchanger between lipid membranes, which suggests the possibility of creating a sterol gradient via phosphoinositide metabolism.
Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion
A novel membrane structure called CUPS is assembled during the secretion of unconventional cargo such as Acb1.
Subunit-dependent modulation of septin assembly: Budding yeast septin Shs1 promotes ring and gauze formation
Substitution of specific terminal subunits within septin complexes and septin phosphorylation drive the formation of distinct higher-order septin assemblies in budding yeast.
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal
The ESCRT-III complex component Shrub plays a pivotal rate-limiting step in late endosomal ligand-independent Notch activation.
Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized
Ubiquitylation of the intracellular domain of Drosophila Delta is necessary for Notch activation.
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors
Beyond homotypic receptor interactions that are required for Eph signaling, ligand-independent association and crosstalk between members of the EphA and -B subclasses determine cell signaling outcomes.
Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure
Imaging of caspase activation in living mouse embryos during development suggests that caspase-mediated cell removal facilitates neural tube closure in a temporally regulated manner.
