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In Focus

Study reveals how changes in subunit composition and phosphorylation alter the organization of septin filaments.

People & Ideas

Overholtzer is working to understand how and why tumor cells invade one another.


Host–pathogen interactions
Host–pathogen interactions


The lipid droplet–associated protein Fsp27 mediates lipid droplet growth by promoting directional lipid transfer from smaller to larger lipid droplets.


In Special Collection: JCB65: Lipid and Membrane Biology

The yeast Kes1p/Osh4p protein functions as a sterol/PI(4)P exchanger between lipid membranes, which suggests the possibility of creating a sterol gradient via phosphoinositide metabolism.

A novel membrane structure called CUPS is assembled during the secretion of unconventional cargo such as Acb1.

Substitution of specific terminal subunits within septin complexes and septin phosphorylation drive the formation of distinct higher-order septin assemblies in budding yeast.

The ESCRT-III complex component Shrub plays a pivotal rate-limiting step in late endosomal ligand-independent Notch activation.

Ubiquitylation of the intracellular domain of Drosophila Delta is necessary for Notch activation.

Beyond homotypic receptor interactions that are required for Eph signaling, ligand-independent association and crosstalk between members of the EphA and -B subclasses determine cell signaling outcomes.

Imaging of caspase activation in living mouse embryos during development suggests that caspase-mediated cell removal facilitates neural tube closure in a temporally regulated manner.


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