JCB65: Lipid and Membrane Biology

In the tenth collection celebrating our 65th anniversary, we explore studies defining membrane biogenesis, fission and fusion, lipid homeostasis and metabolism, signal transduction through sphingolipids and phosphoinositides, the dynamic distribution of lipids within and between membranes or lipid droplets, the impact of lipids on membrane properties, and the involvement of lipids in disease processes. Revisit early studies of F-BAR proteins and protein–lipid interactions that can generate curvature, as well as non-vesicular transport of sterols. Explore work about membrane deformation by the ESCRT system; find early studies of lipid rafts and plasma membrane compartmentalization. Learn how a better understanding of lipids in cellular and subcellular systems leads to new insight about disease mechanisms. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at [email protected]. Find more 65th anniversary collections or browse our From the Archive series.

Image © 2011 West et al.