On the cover
A mouse hippocampal neuron (red) shows numerous mushroom-shaped dendritic spines enriched in PSD-95 (green) along its dendrites. Lippi et al. reveal that the morphology of these structures is modulated by the expression of miRNAs that target the Arpc3 actin-nucleation factor. Image courtesy of Kenneth Young.
See page 889.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
People & Ideas
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis
Genome organizer Satb1 is regulated by p63 and contributes to epidermal morphogenesis by remodeling chromatin structure and gene expression at the epidermal differentiation complex locus.
MCPH1, a protein linked to primary microcephaly, directly modulates condensin II to regulate chromosome condensation and shape.
CENP-C provides a link between existing CENP-A chromatin and the proteins required for new CENP-A nucleosome assembly.
Activated Arf6 directs membrane recruitment of the clathrin adaptor AP-1B to maintain membrane polarization in epithelial cells.
Regulation of Arpc3 by miRNA alters dendritic spine morphology.
S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development
S6 kinase localizes to the active zone in a Brp-dependent manner and collaborates with presynaptic PDK1 to modulate neuronal cell size, bouton size, active zone number, and neurotransmitter release.