On the cover
A vertical cross-section through a threeday-old colony of an undomesticated S. cerevisiae strain reveals its complex, differentiated structure. Galactose in the underlying agar induces the expression of green fluorescent protein in the outermost cell layers but fails to reach interior cells (which only show red autofluorescence) due to the presence of a selectively permeable extracellular matrix. Image courtesy of Váchová et al.
See page 679.
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People & Ideas
Biofilm yeast colonies are complex structures that form through cooperative action of constituent cells and provide a protective environment for cell growth.
Nucleoli directly regulate p53 export and degradation rather than simply sequestering p53 regulatory factors.
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair
M-phase DNA double-strand break repair differs from S-phase repair caused by the action of Cdk1, which prevents RPA-bound single-stranded DNA from activating classical DNA repair pathways.
Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation
The HIV-1 protein Vpr disrupts higher-order chromatin structure by altering histone modification and displacing important heterochromatin proteins, resulting in chromatid cohesion defects.
MIB1 ubiquitin ligase–mediated regulation of internalization of the Wnt receptor RYK is necessary for response to Wnt3a ligand in cell culture and C. elegans.
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
DLK is part of a specialized JNK signaling complex in axons that promotes apoptosis via c-Jun but axon degeneration via distinct JNK substrates.
During membrane budding, coatomer drives initial curvature of the bud, whereas dimeric Arf1 is necessary for membrane scission.
Two distinct domains of GCC185 function in maintaining Golgi structure or in binding to AP-1 to tether retrograde transport vesicles en route to the Golgi.
RNAi screens in Drosophila and human cells for novel actin regulators revealed conserved roles for proteins involved in nuclear actin export, RNA splicing, and ubiquitination.