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Cover Image
Cover Image
On the cover
Wang et al. describe how a diffusion-based gradient of Aurora B phosphorylation spreads outward from centromeres (right image, red). In this monopolar mitotic cell, the gradient is revealed by a FRET-based biosensor targeted to chromatin (right image, green), where blue indicates high phosphorylation levels and yellow indicates lower Aurora B activity (left image). Image courtesy of Enxiu Wang.
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In This Issue
In Focus
People & Ideas
Alejandro Sánchez Alvarado: Bootstrapping flatworms into the molecular age
Sánchez Alvarado studies tissue regeneration in planarians.
Review
Report
The DExD/H box ATPase Dhh1 functions in translational repression, mRNA decay, and processing body dynamics
Dhh1 is a critical determinant in whether mRNAs are translated, stored, or decayed.
Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient
Aurora B kinase is concentrated and activated at centromeres before release and diffusion to reach spatially distributed substrates necessary for cell division.
Article
The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly
Set7 associates with the MyoD transcription factor to enhance expression of genes required for muscle differentiation.
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
Wee1 is essential for normal DNA replication and for genomic stability, at least in part by inhibiting a general DNA damage response induced by the Mus81-Eme1 endonuclease.
c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies
JNK-mediated phosphorylation of the mRNA-decapping protein DCP1a disrupts P body structure, mRNA stability, and gene expression in response to stress and inflammatory stimuli.
Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability
RanBP2 captures RanGTP–importin-β complexes at cytoplasmic fibrils to ensure adequate classical NLS–mediated protein import and cell viability.
Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis
High-resolution microscopy reveals how discrete actin cytoskeletal functions inhibit or promote specific exocytic steps during regulated secretion.
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis
Desmoplakin recruits the centrosomal protein Lis1 to the epidermal cell cortex, where it regulates cortical microtubule organization and desmosome stability.
Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping
The F-actin–stabilizing protein EPLIN is a mechanosensitive regulator of adherens junction remodeling in epithelial cells.
