On the cover
Wang et al. describe how a diffusion-based gradient of Aurora B phosphorylation spreads outward from centromeres (right image, red). In this monopolar mitotic cell, the gradient is revealed by a FRET-based biosensor targeted to chromatin (right image, green), where blue indicates high phosphorylation levels and yellow indicates lower Aurora B activity (left image). Image courtesy of Enxiu Wang.
See page 539.
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People & Ideas
The DExD/H box ATPase Dhh1 functions in translational repression, mRNA decay, and processing body dynamics
Dhh1 is a critical determinant in whether mRNAs are translated, stored, or decayed.
Aurora B kinase is concentrated and activated at centromeres before release and diffusion to reach spatially distributed substrates necessary for cell division.
Set7 associates with the MyoD transcription factor to enhance expression of genes required for muscle differentiation.
Wee1 is essential for normal DNA replication and for genomic stability, at least in part by inhibiting a general DNA damage response induced by the Mus81-Eme1 endonuclease.
JNK-mediated phosphorylation of the mRNA-decapping protein DCP1a disrupts P body structure, mRNA stability, and gene expression in response to stress and inflammatory stimuli.
Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability
RanBP2 captures RanGTP–importin-β complexes at cytoplasmic fibrils to ensure adequate classical NLS–mediated protein import and cell viability.
Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis
High-resolution microscopy reveals how discrete actin cytoskeletal functions inhibit or promote specific exocytic steps during regulated secretion.
Desmoplakin recruits the centrosomal protein Lis1 to the epidermal cell cortex, where it regulates cortical microtubule organization and desmosome stability.
The F-actin–stabilizing protein EPLIN is a mechanosensitive regulator of adherens junction remodeling in epithelial cells.