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In Focus

After mitosis, nuclear membranes form directly from ER cisternae before nuclear pore complex reassembly.

People & Ideas

Eggert uses RNAi and chemistry to develop novel tools for investigating cytokinesis.


The cell biology of disease


Poly ADP-ribosylation polymerases are necessary for recruitment and/or retention of Ku at double-strand breaks during nonhomologous end-joining DNA repair.

Distinct dynein–microtubule interactions are used for asymmetric spindle-positioning tasks in the C. elegans embryo.

The Mim1 complex imports α-helical mitochondrial outer membrane proteins with multiple transmembrane segments.

The mitochondrial import receptor Tom70 and outer membrane protein Mim1 regulate recognition and insertion of the multispan protein Ugo1.


Both Rb and p130 are required for the recruitment of heterochromatin proteins that mediate silencing of proliferation genes in adult cardiac myocytes.

Live-cell imaging and electron tomography show that nuclear pore complexes only assemble on a previously formed nuclear envelope.

Recognition of non-canonical purine•purine RNA motifs by hnRNP A2 mediates targeted delivery of neuronal RNAs to dendrites.

The conserved oligomeric Golgi (COG) complex interacts with the t-SNARE Syntaxin 6 and promotes endosome-to-TGN retrograde trafficking.

The myosin-related motor protein Myo2 collaborates with the rab-GTPase Ypt11 to traffic mitochondria to the yeast bud during cell division.

FGF acts as a positional cue that prevents premature neural crest cell specification and EMT caudally while, at the same time, retinoic acid promotes EMT rostrally.


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