-
Cover Image
Cover Image
On the cover
An apoptotic cell (green) is extruded from the zebrafish larval epidermis by an actin (red) and myosin ring that forms in the adjacent live cells. Gu et al. reveal that dying cells tell their neighbors to squeeze them out of the tissue by producing the sphingolipid sphingosine-1-phosphate.
Image by Tetyana Forostyan, © 2011 Gu et al.
See page 667. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
In Focus
Titin isn't a sleeping giant
Photobleaching reveals that the backbone of muscle myofibrils is surprisingly mobile.
People & Ideas
Harvey McMahon: Ahead of the curve on membrane dynamics
McMahon studies how membranes are bent into shape during vesicle formation and fusion.
In Memoriam
Review
Report
HIV-1 remodels the nuclear pore complex
HIV-1 infection of host cells leads to significant reorganization and redistribution of components of the nuclear envelope and nuclear pore complex.
NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway
The cilia-associated protein NPHP4 is a negative regulator of Hippo signaling that modulates cell proliferation in mammals.
Dual-mode of insulin action controls GLUT4 vesicle exocytosis
Insulin releases an intracellular brake and promotes fusion pore expansion to translocate GLUT4 vesicles, and switches vesicle trafficking between distinct exocytic circuits.
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
Although closely related, RhoA and RhoC have distinct molecular targets and functional roles in cell migration and invasion.
Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway
Apoptotic epithelial cells signal to neighboring cells to induce dying cell extrusion by releasing sphingosine-1-phosphate.
Article
Drosophila histone locus bodies form by hierarchical recruitment of components
An assembly process involving sequential recruitment of components and hierarchical dependency drives formation of the nuclear structures known as histone locus bodies.
Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells
Excessive cell growth in Drosophila intestinal stem cells lacking TSC blocks further cell division.
Centrobin–tubulin interaction is required for centriole elongation and stability
Centrobin recruitment to the centriole biogenesis site and its function during elongation and stabilization of centrioles depend on tubulin interaction.
The conversion of centrioles to centrosomes: essential coupling of duplication with segregation
Plk1-dependent modification of centrioles early in mitosis is necessary for accurate centriole duplication and segregation.
Asymmetric properties of the Chlamydomonas reinhardtii cytoskeleton direct rhodopsin photoreceptor localization
Daughter four-membered rootlet microtubules direct eyespot positioning and assembly.
Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae
The MAP kinase Slt2 is required for both mitophagy and pexophagy, whereas the MAP kinase Hog1 acts specifically in mitophagy.
Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology
The syndecan Sds2 and the innate immunity inhibitor Sarm1 function together and in distinct pathways to promote proper neuronal morphogenesis.
Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres
Contrary to prior models in which titin serves as a stable scaffold in sarcomeres, sarcomeric and soluble titin exchange dynamically in myofibers when calcium levels are low.
