Issues
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Cover Image
Cover Image
On the cover
A C. elegans adult and a polarized embryo express the polarity proteins PAR-2 (green) and PAR-6 (red). Goehring et al. analyze the dynamics of these two proteins as they diffuse between opposing membrane domains and exchange with cytoplasmic pools.
Image courtesy of Nathan Goehring.
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In This Issue
In Focus
PAR proteins cross the boundary
Polarity proteins don't stay on their own side of the membrane.
People & Ideas
Erik Sahai: Getting the whole picture of metastasis
Sahai uses 3D culture and intravital imaging to investigate how tumor cells invade surrounding tissues.
Review
Report
Spatial regulation of Cdc55–PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast
Zds1/2 regulate mitotic progression by directing the nucleocytoplasmic distribution of Cdc55–PP2A.
Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling
Single-cell wound repair in Drosophila involves mechanistically distinct expansion, contraction, and closure phases.
Hax1 regulates neutrophil adhesion and motility through RhoA
Loss of Hax1, which is associated with a severe congenital neutropenia syndrome, impairs neutrophil uropod detachment and directed migration.
Article
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II
CCCTC binding factor (CTCF) mutants that cannot bind components of the polycomb repressive complex-2 (PRC2) do not form the chromatin loops that regulate monoallelic gene expression.
Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z
Binding of histone H2A.Z to the SUN family member Mps3 is chromatin independent.
RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing
RBM4 activates exon skipping of PTB transcripts to suppress PTB expression and counteracts PTB-mediated inhibition of alternative splicing during myogenesis.
Viral protein targeting to the cortical endoplasmic reticulum is required for cell–cell spreading in plants
Sorting signal-mediated oligomerization and localization of the viral protein TGBp3 to curved ER tubules is essential for viral movement between cells in plants.
REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes
The REST/NRSF transcriptional repressor prevents cultured astrocytes from forming DCVs, and its variable expression in human brain cortex astrocytes may account for their functional heterogeneity.
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
A single Wnt can simultaneously activate different pathways with distinct and independent outcomes and reciprocal regulation in human articular chondrocytes.
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
Occludin S408 phosphorylation regulates interactions between occludin, ZO-1, and select claudins to define tight junction molecular structure and barrier function.
PAR proteins diffuse freely across the anterior–posterior boundary in polarized C. elegans embryos
FRAP reveals that a stable PAR boundary requires balancing diffusive flux of PAR proteins between domains with spatial differences in PAR protein membrane affinities.
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