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In This Issue

In Focus

Polarity proteins don't stay on their own side of the membrane.

People & Ideas

Sahai uses 3D culture and intravital imaging to investigate how tumor cells invade surrounding tissues.



Zds1/2 regulate mitotic progression by directing the nucleocytoplasmic distribution of Cdc55–PP2A.

Single-cell wound repair in Drosophila involves mechanistically distinct expansion, contraction, and closure phases.

Loss of Hax1, which is associated with a severe congenital neutropenia syndrome, impairs neutrophil uropod detachment and directed migration.


CCCTC binding factor (CTCF) mutants that cannot bind components of the polycomb repressive complex-2 (PRC2) do not form the chromatin loops that regulate monoallelic gene expression.

Binding of histone H2A.Z to the SUN family member Mps3 is chromatin independent.

RBM4 activates exon skipping of PTB transcripts to suppress PTB expression and counteracts PTB-mediated inhibition of alternative splicing during myogenesis.

Sorting signal-mediated oligomerization and localization of the viral protein TGBp3 to curved ER tubules is essential for viral movement between cells in plants.

The REST/NRSF transcriptional repressor prevents cultured astrocytes from forming DCVs, and its variable expression in human brain cortex astrocytes may account for their functional heterogeneity.

A single Wnt can simultaneously activate different pathways with distinct and independent outcomes and reciprocal regulation in human articular chondrocytes.

Occludin S408 phosphorylation regulates interactions between occludin, ZO-1, and select claudins to define tight junction molecular structure and barrier function.

FRAP reveals that a stable PAR boundary requires balancing diffusive flux of PAR proteins between domains with spatial differences in PAR protein membrane affinities.

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