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In Focus

Researchers reveal way to sharpen vision of double-microscope technique.

People & Ideas

Munro studies how proteins localize within the secretory pathway.



p62 is recruited to the ER at an early-stage autophagosome formation independently of most Atg proteins.


Components of the minichromosome maintenance complex (Mcm2-7) remain indefinitely bound to chromatin during G1 phase and replication arrest.

Degradation of the histone H4 methyltransferase SET8, which regulates chromosome compaction and genomic integrity, is regulated by the CRL4(CDT2) ubiquitin ligase to facilitate DNA replication and repair.

Individual or joint knockdown of the transcriptional coactivators SRC-2 and SRC-3 inhibits lipid accumulation in adipocytes by decreasing PPARγ activity.

miR-125b is identified as a myogenic miRNA that regulates skeletal muscle differentiation by targeting IGF-II under the control of mTOR signaling.

Active translation of HIF-1α requires association and trafficking of HIF mRNA on dynamic microtubules, whereas microtubule disruption represses HIF-1α translation by releasing its mRNA from polysomes and sequestering it to P-bodies.

eNOS-mediated S-nitrosylation of dynamin2 promotes infection of epithelial cells by E. coli.

New methodology improves the spatial resolution and sensitivity of correlative light and EM tomography, revealing new insights into dynamic cellular processes.

ORP5 works together with Niemann Pick C-1 to facilitate exit of cholesterol from endosomes and lysosomes.

In addition to calcium influx, charge movement in the G protein–coupled M2-muscarinic receptor is required for the control of acetylcholine release.

Syndecan-3 may act alone or as a coreceptor with RET to promote cell spreading, neurite outgrowth, and migration of cortical neurons by GNDF, NRTN, and ARTN.

Vascular smooth muscle cell motility relies on interdependent activation of canonical and noncanonical Wnt signal transduction pathways; fibronectin, produced in response to BMP-2–mediated activation of β-catenin, promotes motility by activating an integrin-linked kinase via α4-integrin.

Polychaetoid coordinates receptor trafficking and signaling with adherens junction organization.


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