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Cover Image
Cover Image
On the cover
The dynamin-related GTPase Drp1 (green) localizes in foci where it cleaves the mitochondrial network (red). Otera et al. demonstrate that the protein Mff is required for Drp1 recruitment and mitochondrial fission in mammalian cells. Image © 2010 Hidenori Otera.
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In This Issue
In Focus
Mitochondria help dynamins get a grip
Pair of studies clarifies how organelles attract enzymes that promote their fission.
People & Ideas
Liz Rhoades: Single molecules tell many stories
Rhoades studies protein folding and binding using single-molecule fluorescence techniques.
Review
Report
The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair
Ino80 facilitates restoration of nucleosome structure during NER-mediated repair of UV-induced lesions.
Mad2 inhibits the mitotic kinesin MKlp2
The mitotic checkpoint protein Mad2 halts cell division by interfering with MKlp2-mediated relocation of the chromosome passenger complex from centromeres to the mitotic spindle.
Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation
Disruption of vesicle trafficking results in distortion of nuclear shape and increased nuclear envelope surface area but doesn’t alter the nuclear/cell volume ratio.
CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
A conserved γ-tubulin complex–binding domain in CDK5RAP2 stimulates the microtubule-nucleating activity of γ-TuRC.
Article
Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae
Lte1 interacts with and inhibits the small GTPases Ras and Bud1, blocking polarization until mitosis is complete.
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis
ER stress signaling involving calcium and CaMKII induces NADPH oxidase and oxidative stress, which amplify CHOP-mediated apoptosis via PKR activation.
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes
Structural and functional studies of the Mdv1 dimer reveal how this mitochondria-associated adaptor protein orients and stabilizes the assembly of dynamins on membranes to promote mitochondrial fission.
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
Localization of the dynamin-related GTPase Drp1 to mitochondria relies on the mitochondrial fission factor Mff.
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Phosphorylation of the muscle-specific formin splice variant FHOD3 by CK2 regulates its stability, myofibril targeting, and myofibril integrity.
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway
AP-3 concentrates proteins within large dense-core vesicles to promote regulated exocytosis.
PTP1B regulates Eph receptor function and trafficking
Changes in protein tyrosine phosphatase 1B expression affect duration and amplitude of EphA3 phosphorylation and cell surface concentration.
Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets
Rather than passively binding ligands via immunoreceptors, macrophages capture particles by repeated extension of actin-rich protrusions.
