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Hartman et al. reveal that Drosophila Boi sequesters Hedgehog on the surface of ovarian apical cells to limit follicle stem cell proliferation. When wild-type Boi is replaced by a mutant version (green) that can't bind Hedgehog (red), the signaling molecule accumulates around follicle stem cells, causing them to overproliferate
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In This Issue
In Focus
Setting the spindle's compass
Two control points determine the orientation of epidermal cell divisions.
People & Ideas
Ted Salmon: Kinetochores at the core of it all
Salmon uses cutting-edge microscopy to dissect kinetochore structure and function.
Review
Report
Robust control of mitotic spindle orientation in the developing epidermis
The precise balance of spindle orientations required for proper epidermal morphogenesis is regulated by mInscuteable expression and NuMA localization.
Defects in nuclear pore assembly lead to activation of an Aurora B–mediated abscission checkpoint
In the absence of nuclear pore components, Aurora B delays abscission to ensure that daughter cells separate only when pores are fully formed.
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
Differential localization to the inner and outer mitochondrial membranes regulates PINK1 stability and function.
Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation
The Boi receptor regulates stem cell function by sequestering the diffusible hedgehog ligand.
Article
Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication
Cdc7 phosphorylates Rad18 to integrate S phase progression with postreplication DNA repair, ensuring genome stability.
ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma–lamin A complexes
When in the nucleus, ERK1/2 dislodges the retinoblastoma protein from lamin A, facilitating its rapid phosphorylation.
The RSC chromatin-remodeling complex influences mitotic exit and adaptation to the spindle assembly checkpoint by controlling the Cdc14 phosphatase
Rsc2 promotes Cdc14 release from the nucleolus to free cells from mitotic arrest.
Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes
Phagosomes formed by engagement of complement receptors (CR3) are moved within macrophages by PI3K-driven formation of actin “comet tails” on the phagosomal membrane.
An invasive podosome-like structure promotes fusion pore formation during myoblast fusion
An F-actin–enriched protrusion resembling an invasive podosome promotes fusion pore formation between muscle founder cells and fusion-competent myoblasts.
Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation
Protocadherin-19 and N-cadherin act synergistically during brain morphogenesis in zebrafish.
