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People & Ideas
The precise balance of spindle orientations required for proper epidermal morphogenesis is regulated by mInscuteable expression and NuMA localization.
In the absence of nuclear pore components, Aurora B delays abscission to ensure that daughter cells separate only when pores are fully formed.
Differential localization to the inner and outer mitochondrial membranes regulates PINK1 stability and function.
Cdc7 phosphorylates Rad18 to integrate S phase progression with postreplication DNA repair, ensuring genome stability.
ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma–lamin A complexes
When in the nucleus, ERK1/2 dislodges the retinoblastoma protein from lamin A, facilitating its rapid phosphorylation.
The RSC chromatin-remodeling complex influences mitotic exit and adaptation to the spindle assembly checkpoint by controlling the Cdc14 phosphatase
Rsc2 promotes Cdc14 release from the nucleolus to free cells from mitotic arrest.
Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes
Phagosomes formed by engagement of complement receptors (CR3) are moved within macrophages by PI3K-driven formation of actin “comet tails” on the phagosomal membrane.
An F-actin–enriched protrusion resembling an invasive podosome promotes fusion pore formation between muscle founder cells and fusion-competent myoblasts.
Protocadherin-19 and N-cadherin act synergistically during brain morphogenesis in zebrafish.