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In Focus

Two control points determine the orientation of epidermal cell divisions.

People & Ideas

Salmon uses cutting-edge microscopy to dissect kinetochore structure and function.



The precise balance of spindle orientations required for proper epidermal morphogenesis is regulated by mInscuteable expression and NuMA localization.

In the absence of nuclear pore components, Aurora B delays abscission to ensure that daughter cells separate only when pores are fully formed.

In Special Collection:
JCB65: Mitochondria

Differential localization to the inner and outer mitochondrial membranes regulates PINK1 stability and function.

The Boi receptor regulates stem cell function by sequestering the diffusible hedgehog ligand.


Cdc7 phosphorylates Rad18 to integrate S phase progression with postreplication DNA repair, ensuring genome stability.

When in the nucleus, ERK1/2 dislodges the retinoblastoma protein from lamin A, facilitating its rapid phosphorylation.

Rsc2 promotes Cdc14 release from the nucleolus to free cells from mitotic arrest.

Phagosomes formed by engagement of complement receptors (CR3) are moved within macrophages by PI3K-driven formation of actin “comet tails” on the phagosomal membrane.

An F-actin–enriched protrusion resembling an invasive podosome promotes fusion pore formation between muscle founder cells and fusion-competent myoblasts.

Protocadherin-19 and N-cadherin act synergistically during brain morphogenesis in zebrafish.

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