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The F-BAR protein SRGP-1 (green) localizes to epidermal cell junctions, and dramatically remodels them when overexpressed in a C. elegans embryo. Zaidel-Bar et al. reveal that SRGP-1 promotes the formation of intercellular adhesions by bending the plasma membrane outward.
See page 761.
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An Hsp70 transgene system is used to identify cis-elements required for gene-specific association with nuclear speckles.
Cep152 interacts with the cryptic Polo-box of Plk4 and is required for Plk4-induced centriole overduplication.
Degradation of Plk1 during mitotic exit allows recruitment of the Cep55 abscission factor and timely cytokinesis.
SRGP-1 activity leads to outward bending and projections of membranes at cell–cell junctions, promoting robust adhesion between cells during embryonic closure events.
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
The association between flotillin microdomains and the cortical cytoskeleton controls myosin IIa activation and neutrophil chemotaxis.
Mitotic spindle disassembly occurs via distinct subprocesses driven by the anaphase-promoting complex, Aurora B kinase, and kinesin-8
A large-scale analysis of spindle disassembly in budding yeast identifies factors required for disengagement of spindle halves, arrest of spindle elongation, and depolymerization of interpolar microtubules.
Repression of E2F target genes is required for cell cycle arrest in Rb family (Rb, p107, and p130)-deficient cells.
p110-β associates with the Vps34–Vps15–Beclin 1–Atg14L complex and facilitates generation of PtdIns(3)P to promote autophagy.
Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering
An AP-3–binding site required for vesicle–vacuole fusion is masked when Vps41 is associated with highly curved membranes, such as endosomes, but is exposed at membranes with lower curvature, such as vacuoles, because of phosphorylation of the membrane-binding motif.
New steps in the process of conversion of proplatelet extensions from megakaryocytes into mature platelets are defined.
The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo
In vivo analysis of subcellular dynamics in the zebrafish cerebellum provides new insights into centrosome positioning during vertebrate brain differentiation.