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Cover Image
Cover Image
On the cover
The F-BAR protein SRGP-1 (green) localizes to epidermal cell junctions, and dramatically remodels them when overexpressed in a C. elegans embryo. Zaidel-Bar et al. reveal that SRGP-1 promotes the formation of intercellular adhesions by bending the plasma membrane outward.
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In This Issue
In Focus
People & Ideas
Craig Thompson: The method to cancer's madness
Thompson studies the metabolic requirements of dividing immune and cancer cells.
Review
Report
Hsp70 gene association with nuclear speckles is Hsp70 promoter specific
An Hsp70 transgene system is used to identify cis-elements required for gene-specific association with nuclear speckles.
Cep152 interacts with Plk4 and is required for centriole duplication
Cep152, the orthologue of Drosophila Asterless, is a Plk4 target that functions with Plk4 in centriole assembly.
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome
Cep152 interacts with the cryptic Polo-box of Plk4 and is required for Plk4-induced centriole overduplication.
Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission
SEPT9 localizes the vesicle-tethering exocyst complex to the midbody to promote daughter cell separation.
Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission
Degradation of Plk1 during mitotic exit allows recruitment of the Cep55 abscission factor and timely cytokinesis.
The F-BAR domain of SRGP-1 facilitates cell–cell adhesion during C. elegans morphogenesis
SRGP-1 activity leads to outward bending and projections of membranes at cell–cell junctions, promoting robust adhesion between cells during embryonic closure events.
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
The association between flotillin microdomains and the cortical cytoskeleton controls myosin IIa activation and neutrophil chemotaxis.
Article
PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
SUMOylation of TopoIIα inhibits its decatenation activity, preventing resolution of tangled DNA at centromeres before anaphase onset.
Mitotic spindle disassembly occurs via distinct subprocesses driven by the anaphase-promoting complex, Aurora B kinase, and kinesin-8
A large-scale analysis of spindle disassembly in budding yeast identifies factors required for disengagement of spindle halves, arrest of spindle elongation, and depolymerization of interpolar microtubules.
G1 arrest and differentiation can occur independently of Rb family function
Repression of E2F target genes is required for cell cycle arrest in Rb family (Rb, p107, and p130)-deficient cells.
The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy
p110-β associates with the Vps34–Vps15–Beclin 1–Atg14L complex and facilitates generation of PtdIns(3)P to promote autophagy.
Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering
An AP-3–binding site required for vesicle–vacuole fusion is masked when Vps41 is associated with highly curved membranes, such as endosomes, but is exposed at membranes with lower curvature, such as vacuoles, because of phosphorylation of the membrane-binding motif.
Cytoskeletal mechanics of proplatelet maturation and platelet release
New steps in the process of conversion of proplatelet extensions from megakaryocytes into mature platelets are defined.
The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo
In vivo analysis of subcellular dynamics in the zebrafish cerebellum provides new insights into centrosome positioning during vertebrate brain differentiation.
