Skip to Main Content

Advertisement

Issues

  • Cover Image

    Cover Image

    issue cover

    On the cover
    A mitotic cell shows incorrect attachments between spindle microtubules (green) and kinetochores (red) when the Aurora B kinase, which normally eliminates misattachments, is inhibited. Liu et al. reveal that protein phosphatase I is recruited to kinetochores to oppose Aurora B and stabilize correct microtubule binding.
    See page 809.

  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study identifies a new way for actin filaments to polymerize in vivo.

People & Ideas

Hilton's passion for blood makes his pulse race.

Review

Report

Enhanced polymerization of actin in latrunculin A–treated aip1Δ cells shows that filament assembly does not occur from monomeric actin alone in vivo.

Article

Improper chromosome pairing, synapsis, and segregation impair meiotic progression in the absence of the BLM helicase in mammalian cells.

hMis14 and HP1 depend on each other to localize to the kinetochore and inner centromere, respectively.

KNL targets PP1 to kinetochores, where it antagonizes Aurora B activity.

ERO1-β has an unexpected and selective function for oxidative protein folding in insulin-producing cells.

The TNF-related cytokine TWEAK promotes skeletal muscle atrophy that is associated with classical disuse syndromes.

Although both Mcl-1 and Bcl-xL keep proapoptotic Bak in check, it is the loss of Mcl-1 that sensitizes cells to death receptor–mediated apoptosis.

Only the p110α isoform of PI3K mediates the association of VE-cadherin with Pyk2, a Rac GEF and the p85 PI3K regulatory subunit, to reduce junctional integrity in response to TNF.

FAK-mediated myosin-dependent paxillin phosphorylation is necessary to bring vinculin to maturing focal adhesions, reinforcing the link between the cytoskeleton and the ECM.

FRET experiments model integrin conformation changes in adherent cells.

Arf assembles a complex containing Miz1, heterochromatin, and histone H3K3 to block expression of genes involved in cell adhesion and signal transduction. The resulting blockade of cell–cell and cell–matrix interactions facilitates elimination of cells carrying oncogenic mutations.

Clathrin-coated pit size and dynamic behavior varies with low density lipoprotein receptor (LDLR) expression levels in a manner dependent on the LDLR-specific adaptors, Dab2 and ARH.

Loss of FGFRs results in skin abnormalities due to activation of keratinocytes and epidermal T cells.

The small GTPase Arl13b regulates ciliary transmembrane protein localizations and anterograde IFT assembly stability.

Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal