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Study identifies a new way for actin filaments to polymerize in vivo.

People & Ideas

Hilton's passion for blood makes his pulse race.



Enhanced polymerization of actin in latrunculin A–treated aip1Δ cells shows that filament assembly does not occur from monomeric actin alone in vivo.


Improper chromosome pairing, synapsis, and segregation impair meiotic progression in the absence of the BLM helicase in mammalian cells.

hMis14 and HP1 depend on each other to localize to the kinetochore and inner centromere, respectively.

KNL targets PP1 to kinetochores, where it antagonizes Aurora B activity.

ERO1-β has an unexpected and selective function for oxidative protein folding in insulin-producing cells.

The TNF-related cytokine TWEAK promotes skeletal muscle atrophy that is associated with classical disuse syndromes.

Although both Mcl-1 and Bcl-xL keep proapoptotic Bak in check, it is the loss of Mcl-1 that sensitizes cells to death receptor–mediated apoptosis.

Only the p110α isoform of PI3K mediates the association of VE-cadherin with Pyk2, a Rac GEF and the p85 PI3K regulatory subunit, to reduce junctional integrity in response to TNF.

FAK-mediated myosin-dependent paxillin phosphorylation is necessary to bring vinculin to maturing focal adhesions, reinforcing the link between the cytoskeleton and the ECM.

FRET experiments model integrin conformation changes in adherent cells.

Arf assembles a complex containing Miz1, heterochromatin, and histone H3K3 to block expression of genes involved in cell adhesion and signal transduction. The resulting blockade of cell–cell and cell–matrix interactions facilitates elimination of cells carrying oncogenic mutations.

Clathrin-coated pit size and dynamic behavior varies with low density lipoprotein receptor (LDLR) expression levels in a manner dependent on the LDLR-specific adaptors, Dab2 and ARH.

Loss of FGFRs results in skin abnormalities due to activation of keratinocytes and epidermal T cells.

The small GTPase Arl13b regulates ciliary transmembrane protein localizations and anterograde IFT assembly stability.

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