On the cover
Martin et al. show that adherens junctions transmit contractile forces between cells, generating tension in epithelial tissues that influences the shape of individual cells. When junctions are partially disrupted, the imbalance in tensile force tears cells apart, although they remain connected by thin membrane tethers.
See page 735.
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WEE1 and CHK1 jointly regulate Cdk activity to prevent DNA damage during replication.
ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
ATR recognizes critically short telomeres as fragile sites and protects them from chromosomal fusions.
Chromatin entanglements undergo specific protein-mediated compaction to fold into mitotic chromosomes.
Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases
An automated, quantitative 4D image analysis method is used to track kinetochore dynamics in metaphase cells.
Kinetochore protein CENP-I is regulated by SUMO protease SENP6 and RNF4, a ubiquitin ligase which targets polysumoylated proteins for degradation during mitosis.
The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts
The orientation of stem cell divisions is maintained beyond one cell cycle thanks to microtubule polymerization and apical centrosome positioning.
Additional factors combine with the core Hrd1 complex in a modular fashion, enabling it to recognize a variety of substrates.
The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation
Defective attenuation of BMP signaling causes synapses to overgrow in Drosophila Ema mutants due to impaired endosomal maturation.
Transcription factor Twist promotes cell junctions to link individual cells into a contractile network responsible for the apical constriction pulses during epithelial morphogenesis.