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Cover Image
Cover Image
On the cover
Martin et al. show that adherens junctions transmit contractile forces between cells, generating tension in epithelial tissues that influences the shape of individual cells. When junctions are partially disrupted, the imbalance in tensile force tears cells apart, although they remain connected by thin membrane tethers.
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In This Issue
In Focus
Centrosomes remember which way is up
Microtubule-based memory helps orient dividing brain stem cells.
People & Ideas
Isabelle Vernos: Motoring around the mitotic spindle
Vernos uses cutting-edge microscopy to track spindle assembly in Xenopus eggs.
Editorial
Review
Report
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
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Article
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ATR recognizes critically short telomeres as fragile sites and protects them from chromosomal fusions.
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An automated, quantitative 4D image analysis method is used to track kinetochore dynamics in metaphase cells.
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Kinetochore protein CENP-I is regulated by SUMO protease SENP6 and RNF4, a ubiquitin ligase which targets polysumoylated proteins for degradation during mitosis.
The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts
The orientation of stem cell divisions is maintained beyond one cell cycle thanks to microtubule polymerization and apical centrosome positioning.
Modularity of the Hrd1 ERAD complex underlies its diverse client range
Additional factors combine with the core Hrd1 complex in a modular fashion, enabling it to recognize a variety of substrates.
The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation
Defective attenuation of BMP signaling causes synapses to overgrow in Drosophila Ema mutants due to impaired endosomal maturation.
Integration of contractile forces during tissue invagination
Transcription factor Twist promotes cell junctions to link individual cells into a contractile network responsible for the apical constriction pulses during epithelial morphogenesis.
