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In Focus

Cryoelectron tomography materializes the (missing) nexin link.

People & Ideas

Kapoor uses small molecule inhibitors and high-resolution microscopy to explore metaphase chromosome alignment.



It's the degree of activation, not a specific cyclin-dependent kinase, that is important for genome maintenance in postreplicative cells.

A new technique illuminates differential H3S10 phosphorylation dynamics in normal and cancer cells; spatial and temporal regulation of this process by aurora B kinase is required for accurate chromosome segregation.

Selective ubiquitination of Aurora B by different Cul3 adaptors targets it at the correct time to the correct place during mitosis.


The nuclear repositioning of specific genes may be a novel diagnostic strategy to distinguish malignant from normal tissue.

Chromatin-remodeling factor ISWI is a microtubule-associated protein that contributes to chromosome segregation by stabilizing microtubules during anaphase.

Astral microtubule contact with the cortex is not required to position the furrow for cytokinesis.

Fwd shuttles Rab11 to the cleavage furrow by both kinase-dependent and -independent mechanisms.

mTor, acting mainly via mTORC1, controls dystrophin transcription in a raptor- and rictor-independent mechanism.

Accumulation of autophagosomes because of impaired autophagy during valosin-containing protein (VCP)–linked dementia is explained by the absence or reduced activity of VCP.

The ORP lipid-binding domain can contact two membranes simultaneously to facilitate sterol extraction or delivery at one membrane in response to the lipid composition of the other.

Poc1 shores up basal bodies to support cilia formation in Tetrahymena thermophila, zebrafish, and humans; Poc1 depletion causes phenotypes commonly seen in ciliopathies.

Elegant cryoelectron tomography reveals that the nexin link between microtubule doublets in 9 + 2 axonemal structures, critical for their ability to bend, is the dynein regulatory complex.

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