On the cover
The mitotic spindle (orange) segregates DNA (blue) in the dividing cells of a sand dollar embryo. von Dassow et al. demonstrate that spindle microtubules don't need to touch the cell cortex for the cleavage furrow to assemble in the right place.
See page 831.
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People & Ideas
It's the degree of activation, not a specific cyclin-dependent kinase, that is important for genome maintenance in postreplicative cells.
Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase
A new technique illuminates differential H3S10 phosphorylation dynamics in normal and cancer cells; spatial and temporal regulation of this process by aurora B kinase is required for accurate chromosome segregation.
The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis
Selective ubiquitination of Aurora B by different Cul3 adaptors targets it at the correct time to the correct place during mitosis.
Chromatin-remodeling factor ISWI is a microtubule-associated protein that contributes to chromosome segregation by stabilizing microtubules during anaphase.
Fwd shuttles Rab11 to the cleavage furrow by both kinase-dependent and -independent mechanisms.
mTor, acting mainly via mTORC1, controls dystrophin transcription in a raptor- and rictor-independent mechanism.
Accumulation of autophagosomes because of impaired autophagy during valosin-containing protein (VCP)–linked dementia is explained by the absence or reduced activity of VCP.
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues
The ORP lipid-binding domain can contact two membranes simultaneously to facilitate sterol extraction or delivery at one membrane in response to the lipid composition of the other.
Poc1 shores up basal bodies to support cilia formation in Tetrahymena thermophila, zebrafish, and humans; Poc1 depletion causes phenotypes commonly seen in ciliopathies.
Elegant cryoelectron tomography reveals that the nexin link between microtubule doublets in 9 + 2 axonemal structures, critical for their ability to bend, is the dynein regulatory complex.