On the cover
Microtubules (green) point to an apoptotic cell in the center of an epithelial sheet, positioning a band of actin (red) and myosin II to squeeze the dying cell and its condensed chromosomes (blue) out of the monolayer. See page 693.
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In This Issue
People & Ideas
AlkB PCNA-interacting motif (APIM) is present in >200 proteins and may mediate PCNA binding during genotoxic stress.
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.
Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate
Embryonic stem cell pluripotency, once achieved, triggers a switch in promoter affinity for Oct4, which leads to cardiogenesis.
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments
Mitosis happens faster in Taxol-treated cells because Taxol-stabilized kinetochores get through the checkpoint faster.
Human cytomegalovirus uses an E3 ubiquitin ligase to divert MHC I molecules into the ER-associated degradation pathway for destruction.
Communication between microtubules and actin/myosin networks determine epithelial cell extrusion polarity.
Autophagy can help cells to dispose of damaged proteins, alleviating cell death in genetic models of Huntington’s disease and retinal degradation.
Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis
A meiosis-conditional pds5 allele in yeast provides a more detailed understanding of homologue pairing and synaptonemal complex formation.
Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells
Multiple mitotic motors coordinate their signals to ensure that the actomyosin contractile ring forms in the right place during cytokinesis.
Spatial cues regulate cytokinesis: fully elongated spindles initiate cytokinesis in late anaphase, and the resulting cellular asymmetry triggers the process to end.