Issues

How cells set the where and when of cytokinesis

From the highest mountains to biology's own Everest—the brain—Reichardt tackles the biggest challenges of climbing and biology.

AlkB PCNA-interacting motif (APIM) is present in >200 proteins and may mediate PCNA binding during genotoxic stress.

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.

Embryonic stem cell pluripotency, once achieved, triggers a switch in promoter affinity for Oct4, which leads to cardiogenesis.

Mitosis happens faster in Taxol-treated cells because Taxol-stabilized kinetochores get through the checkpoint faster.

Human cytomegalovirus uses an E3 ubiquitin ligase to divert MHC I molecules into the ER-associated degradation pathway for destruction.

Communication between microtubules and actin/myosin networks determine epithelial cell extrusion polarity.

Autophagy can help cells to dispose of damaged proteins, alleviating cell death in genetic models of Huntington’s disease and retinal degradation.

A meiosis-conditional pds5 allele in yeast provides a more detailed understanding of homologue pairing and synaptonemal complex formation.

Multiple mitotic motors coordinate their signals to ensure that the actomyosin contractile ring forms in the right place during cytokinesis.

Spatial cues regulate cytokinesis: fully elongated spindles initiate cytokinesis in late anaphase, and the resulting cellular asymmetry triggers the process to end.

A regulator of G protein signaling, RGS2, moonlights in protein synthesis control.