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Cover Image
Cover Image
On the cover
Tropomodulin1 (green) is required for the regular hexagonal packing of mouse lens fiber cells, binding to a sub population of F-actin (red) that connects a spectrin-based network underlying the cell membranes. See page 915. - PDF Icon PDF LinkTable of Contents
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In This Issue
In Focus
Rab2 directs a stop-loss program
Small GTPase supports dense core vesicle maturation in worm neurons.
People & Ideas
Iain Cheeseman: A strong attachment to kinetochores
Cheeseman is looking forward to a new era of research on chromosome segregation.
Review
Report
Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis
CHOP turns on ERO1-α to release calcium via IP3R and trigger cell death in response to ER stress.
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion
The soluble and membrane-anchored isoforms of Mgm1 are only active when they work together (in trans).
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
Brain-specific Drp1 knockout mice demonstrate that Drp1-mediated organelle division is important for development, mitochondrial morphogenesis, and apoptosis.
Regulation of dynein-driven microtubule sliding by the axonemal protein kinase CK1 in Chlamydomonas flagella
CK1 puts the brakes on dynein activity when added to purified axonemes in vitro, presumably to regulate how flagella bend.
Article
Entropic organization of interphase chromosomes
Nonspecific forces, in addition to biophysical properties, lead to the careful arrangement of chromosomes in the nucleus.
Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
The epigenetic mark indicative of DNA UV damage or double-strand breaks is achieved via a common pathway regardless of the cause of damage.
Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0
The step by step assembly process from preribosome in the nucleus to translation-competent 60S ribosome subunit in the cytoplasm is revealed (also see Kemmler et al. in this issue).
Yvh1 is required for a late maturation step in the 60S biogenesis pathway
The step by step assembly process from preribosome in the nucleus to translation-competent 60S ribosome subunit in the cytoplasm is revealed (also see Lo et al. in this issue).
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
Uncoordinated movement in Rab2 mutants is caused by impaired retention of cargo on dense core vesicles, not by defective synaptic vesicle release. (Also see the companion article by Sumakovic et al. in this issue.)
UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
Uncoordinated movement in Rab2 mutants is caused by impaired retention of cargo on dense core vesicles, not by defective synaptic vesicle release. (Also see the companion article by Edwards et al. in this issue.)
Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens
The spectrin–actin network is disrupted in Tmod1 mutants, disturbing fiber cell morphology, and disordering lens cell organization.
