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JCB65: DNA replication and repair

In the eighth collection celebrating our 65th anniversary, we revisit studies of how features of chromosome structure are linked to nuclear function through the study of DNA replication and its organization, work detailing the pre-replication and replication complexes, their assembly during the cell cycle, and their relationship to replication forks and replication timing. Important studies of DNA damage responses and DNA repair are included, providing fundamental insight into the machinery underlying repair, such as the study identifying γ-H2AX foci as an evolutionarily conserved response to double-stranded DNA breaks. We explore more recent work shedding light into the mechanisms maintaining genome stability, including during replication stress, with studies implicating reversed forks as important intermediates for replication-associated processing events. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at jcellbiol@rockefeller.edu. Find more 65th anniversary collections or browse our From the Archive series.

Image from Lima-de-Faria, 1959.

Special Collection Image
Yuntao Xia; Irena L. Ivanovska; Kuangzheng Zhu; Lucas Smith; Jerome Irianto; Charlotte R. Pfeifer; Cory M. Alvey; Jiazheng Ji; Dazhen Liu; Sangkyun Cho; Rachel R. Bennett; Andrea J. Liu; Roger A. Greenberg; Dennis E. Discher
DOI: 10.1083/jcb.201711161
Wanqing Xiang; M. Julia Roberti; Jean-Karim Hériché; Sébastien Huet; Stephanie Alexander; Jan Ellenberg
DOI: 10.1083/jcb.201709074
Emily J. Platt; Leslie Smith; Mathew J. Thayer
DOI: 10.1083/jcb.201707082
Bramwell G. Lambrus; Yumi Uetake; Kevin M. Clutario; Vikas Daggubati; Michael Snyder; Greenfield Sluder; Andrew J. Holland
DOI: 10.1083/jcb.201502089
Saravanabhavan Thangavel; Matteo Berti; Maryna Levikova; Cosimo Pinto; Shivasankari Gomathinayagam; Marko Vujanovic; Ralph Zellweger; Hayley Moore; Eu Han Lee; Eric A. Hendrickson; Petr Cejka; Sheila Stewart; Massimo Lopes; Alessandro Vindigni
DOI: 10.1083/jcb.201406100
Ralph Zellweger; Damian Dalcher; Karun Mutreja; Matteo Berti; Jonas A. Schmid; Raquel Herrador; Alessandro Vindigni; Massimo Lopes
DOI: 10.1083/jcb.201406099
Kai J. Neelsen; Isabella M.Y. Zanini; Raquel Herrador; Massimo Lopes
DOI: 10.1083/jcb.201212058
Dimitri Conomos; Michael D. Stutz; Mark Hills; Axel A. Neumann; Tracy M. Bryan; Roger R. Reddel; Hilda A. Pickett
DOI: 10.1083/jcb.201207189
Simon Bekker-Jensen; Claudia Lukas; Risa Kitagawa; Fredrik Melander; Michael B. Kastan; Jiri Bartek; Jiri Lukas
DOI: 10.1083/jcb.200510130
Irene M. Ward; Bernardo Reina-San-Martin; Alexandru Olaru; Kay Minn; Koji Tamada; Julie S. Lau; Marilia Cascalho; Lieping Chen; Andre Nussenzweig; Ferenc Livak; Michel C. Nussenzweig; Junjie Chen
DOI: 10.1083/jcb.200403021
Irene Rappold; Kuniyoshi Iwabuchi; Takayasu Date; Junjie Chen
DOI: 10.1083/jcb.153.3.613
Emmy P. Rogakou; Chye Boon; Christophe Redon; William M. Bonner
DOI: 10.1083/jcb.146.5.905
Daniela S. Dimitrova; Ivan T. Todorov; Thomas Melendy; David M. Gilbert
DOI: 10.1083/jcb.146.4.709
Dean A. Jackson; Ana Pombo
DOI: 10.1083/jcb.140.6.1285
R T O'Keefe; S C Henderson; D L Spector
DOI: 10.1083/jcb.116.5.1095
R Bravo; H Macdonald-Bravo
DOI: 10.1083/jcb.105.4.1549
A. Lima-de-Faria
DOI: 10.1083/jcb.6.3.457
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