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Steven M. Sine
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Journal Articles

Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor

Kathiresan Natarajan, Nuriya Mukhtasimova, Jeremías Corradi, Matías Lasala, Cecilia Bouzat, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2020) 152 (9): e202012606.
https://doi.org/10.1085/jgp.202012606
Published: 23 July 2020
View article titled, Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor
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Journal Articles

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel

In Special Collection:
Ion Channel Structure & Function 2018 , Ion Channels in the Era of Precision Biology 2018 , Ligand-gated ion channels , Molecular Biophysics of Membranes 2018
Nuriya Mukhtasimova, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2018) 150 (5): 713–729.
https://doi.org/10.1085/jgp.201711881
Published: 21 April 2018
View article titled, Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel
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Includes: Supplementary data
Journal Articles

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR

Nuriya Mukhtasimova, Corrie J.B. daCosta, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2016) 148 (1): 43–63.
https://doi.org/10.1085/jgp.201611584
Published: 27 June 2016
View article titled, Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR
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Includes: Supplementary data
Journal Articles

Nicotinic Receptor Interloop Proline Anchors β1-β2 and Cys loops in Coupling Agonist Binding to Channel Gating

Won Yong Lee, Chris R. Free, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2008) 132 (2): 265–278.
https://doi.org/10.1085/jgp.200810014
Published: 28 July 2008
View article titled, Nicotinic Receptor Interloop Proline Anchors β1-β2 and Cys loops in Coupling Agonist Binding to Channel Gating
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Journal Articles

Initial Coupling of Binding to Gating Mediated by Conserved Residues in the Muscle Nicotinic Receptor

Nuriya Mukhtasimova, Chris Free, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2005) 126 (1): 23–39.
https://doi.org/10.1085/jgp.200509283
Published: 13 June 2005
View article titled, Initial Coupling of Binding to Gating Mediated by Conserved Residues in the Muscle Nicotinic Receptor
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Journal Articles

Invariant Aspartic Acid in Muscle Nicotinic Receptor Contributes Selectively to the Kinetics of Agonist Binding

Won Yong Lee, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2004) 124 (5): 555–567.
https://doi.org/10.1085/jgp.200409077
Published: 25 October 2004
View article titled, Invariant Aspartic Acid in Muscle Nicotinic Receptor Contributes Selectively to the Kinetics of Agonist Binding
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Journal Articles

Naturally Occurring Mutations at the Acetylcholine Receptor Binding Site Independently Alter ACh Binding and Channel Gating

Steven M. Sine, Xing-Ming Shen, Hai-Long Wang, Kinji Ohno, Won-Yong Lee, Akira Tsujino, Joan Brengmann, Nina Bren, Jiri Vajsar, Andrew G. Engel
Journal: Journal of General Physiology
J Gen Physiol (2002) 120 (4): 483–496.
https://doi.org/10.1085/jgp.20028568
Published: 16 September 2002
View article titled, Naturally Occurring Mutations at the Acetylcholine Receptor Binding Site Independently Alter ACh Binding and Channel Gating
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Journal Articles

Mechanism of Tacrine Block at Adult Human Muscle Nicotinic Acetylcholine Receptors

Richard J. Prince, Richard A. Pennington, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2002) 120 (3): 369–393.
https://doi.org/10.1085/jgp.20028583
Published: 12 August 2002
View article titled, Mechanism of Tacrine Block at Adult Human Muscle Nicotinic Acetylcholine Receptors
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Journal Articles

Fundamental Gating Mechanism of Nicotinic Receptor Channel Revealed by Mutation Causing a Congenital Myasthenic Syndrome

Hai-Long Wang, Kinji Ohno, Margherita Milone, Joan M. Brengman, Amelia Evoli, Anna-Paola Batocchi, Lefkos T. Middleton, Kyproula Christodoulou, Andrew G. Engel, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (2000) 116 (3): 449–462.
https://doi.org/10.1085/jgp.116.3.449
Published: 28 August 2000
View article titled, Fundamental Gating Mechanism of Nicotinic Receptor Channel Revealed by Mutation Causing a Congenital Myasthenic Syndrome
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Journal Articles

The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element

Claudio Grosman, Frank N. Salamone, Steven M. Sine, Anthony Auerbach
Journal: Journal of General Physiology
J Gen Physiol (2000) 116 (3): 327–340.
https://doi.org/10.1085/jgp.116.3.327
Published: 14 August 2000
View article titled, The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element
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Journal Articles

Mutation in the M1 Domain of the Acetylcholine Receptor α Subunit Decreases the Rate of Agonist Dissociation

Hai-Long Wang, Anthony Auerbach, Nina Bren, Kinji Ohno, Andrew G. Engel, Steven M. Sine
Journal: Journal of General Physiology
J Gen Physiol (1997) 109 (6): 757–766.
https://doi.org/10.1085/jgp.109.6.757
Published: 01 June 1997
View article titled, Mutation in the M1 Domain of the Acetylcholine Receptor α Subunit Decreases the Rate of Agonist Dissociation
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