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Ligand-gated ion channels

The collection features articles on the structure and function of glutamate-, acetylcholine-, and ATP-gated ion channels, a hypothesis on allosteric regulation of ion channel function by the lipid membrane and a review of our current understanding of NMDA receptors.

Ligand-gated ion channels are membrane proteins that transduce the binding of a ligand, such as a neurotransmitter, into an electrical response. In recent years, our understanding of the mechanisms by which ligands bind to and open these ion channels has been revolutionized by advances in structural biology techniques. Such structural studies have, in turn, uncovered a wealth of questions to address using functional and computational tools, as exemplified in this collection.

Image © 2018 Ahring et al.

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Sushree Tripathy; Wenjun Zheng; Anthony Auerbach
DOI: 10.1085/jgp.201812212
Alistair G. Fryatt; Sudad Dayl; Anastasios Stavrou; Ralf Schmid; Richard J. Evans
DOI: 10.1085/jgp.201812108
Edward Y. Shi; Christine L. Yuan; Matthew T. Sipple; Jayasri Srinivasan; Christopher P. Ptak; Robert E. Oswald; Linda M. Nowak
DOI: 10.1085/jgp.201812209
Timothy J. Wilding; James E. Huettner
DOI: 10.1085/jgp.201812234
Ofer Kimchi; Sarah L. Veatch; Benjamin B. Machta
DOI: 10.1085/jgp.201711900
Kasper B. Hansen; Feng Yi; Riley E. Perszyk; Hiro Furukawa; Lonnie P. Wollmuth; Alasdair J. Gibb; Stephen F. Traynelis
DOI: 10.1085/jgp.201812032
Nuriya Mukhtasimova; Steven M. Sine
DOI: 10.1085/jgp.201711881
Philip Kiær Ahring; Vivian Wan Yu Liao; Thomas Balle
DOI: 10.1085/jgp.201711846
Giorgio Fois; Veronika Eva Winkelmann; Lara Bareis; Laura Staudenmaier; Elena Hecht; Charlotte Ziller; Konstantin Ehinger; Jürgen Schymeinsky; Christine Kranz; Manfred Frick
DOI: 10.1085/jgp.201711870
Patricia M.G.E. Brown; Hugo McGuire; Derek Bowie
DOI: 10.1085/jgp.201711895
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