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Ligand-gated ion channels

We are pleased to present a collection of articles on ligand-gated ion channels that have been curated from recent issues of JGP.

Ligand-gated ion channels are membrane proteins that transduce the binding of a ligand, such as a neurotransmitter, into an electrical response. In recent years, our understanding of the mechanisms by which ligands bind to and open these ion channels has been revolutionized by advances in structural biology techniques. Such structural studies have, in turn, uncovered a wealth of questions to address using functional and computational tools, as exemplified in this collection.

Along with cutting-edge Research Articles on the structure and function of glutamate-, acetylcholine-, and ATP-gated ion channels, the collection features a Hypothesis on allosteric regulation of ion channel function by the lipid membrane and a Review of our current understanding of NMDA receptors.

Image © 2018 Ahring et al.

Special Collection Image
Article
Sushree Tripathy; Wenjun Zheng; Anthony Auerbach
DOI: 10.1085/jgp.201812212
Article
Alistair G. Fryatt; Sudad Dayl; Anastasios Stavrou; Ralf Schmid; Richard J. Evans
DOI: 10.1085/jgp.201812108
Article
Edward Y. Shi; Christine L. Yuan; Matthew T. Sipple; Jayasri Srinivasan; Christopher P. Ptak; Robert E. Oswald; Linda M. Nowak
DOI: 10.1085/jgp.201812209
Article
Timothy J. Wilding; James E. Huettner
DOI: 10.1085/jgp.201812234
Hypothesis
Ofer Kimchi; Sarah L. Veatch; Benjamin B. Machta
DOI: 10.1085/jgp.201711900
Review
Kasper B. Hansen; Feng Yi; Riley E. Perszyk; Hiro Furukawa; Lonnie P. Wollmuth; Alasdair J. Gibb; Stephen F. Traynelis
DOI: 10.1085/jgp.201812032
Article
Nuriya Mukhtasimova; Steven M. Sine
DOI: 10.1085/jgp.201711881
Article
Philip Kiær Ahring; Philip Kiær Ahring; Vivian Wan Yu Liao; Thomas Balle
DOI: 10.1085/jgp.201711846
Article
Giorgio Fois; Veronika Eva Winkelmann; Lara Bareis; Laura Staudenmaier; Elena Hecht; Charlotte Ziller; Konstantin Ehinger; Jürgen Schymeinsky; Christine Kranz; Manfred Frick
DOI: 10.1085/jgp.201711870
Article
Patricia M.G.E. Brown; Hugo McGuire; Derek Bowie
DOI: 10.1085/jgp.201711895
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