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Ion Channels in the Era of Precision Biology 2018

With relevance to the 2018 Ion Channels Gordon Research Conference on Excitable Membranes in the Era of Precision Biology, this collection features recent ground-breaking research and reviews from Alessio Accardi, Michael Puljung, Tzyh-Chang Hwang, William Zagotta, and Douglas Bayliss.

Communication

Functional consequences of deglycosylation assessed in the same population of K_V channels

Angelica Lopez-Rodriguez; Miguel Holmgren

https://doi.org/10.1085/jgp.201711958

Communication

Isosteric charge ablation in a voltage sensor

Daniel T. Infield; Elizabeth E.L. Lee; Jason D. Galpin; Grace D. Galles; Francisco Bezanilla; Christopher A. Ahern

https://doi.org/10.1085/jgp.201812075

Communication

LRRC8 protein regions essential for VRAC function

Toshiki Yamada; Kevin Strange

https://doi.org/10.1085/jgp.201812016

Communication

Cypher regulates Ca_V1.2 calcium channel

Haijie Yu; Can Yuan; Ruth E. Westenbroek; William A. Catterall

https://doi.org/10.1085/jgp.201711818

Article

Zn²⁺-dependent conformational coupling in Hv1

Victor De La Rosa; Ashley L. Bennett; Ian Scott Ramsey

https://doi.org/10.1085/jgp.201711822

Article

His¹⁶⁸ is an internal pH sensor of hH_V1

Vladimir V. Cherny; Deri Morgan; Sarah Thomas; Susan M.E. Smith; Thomas E. DeCoursey

https://doi.org/10.1085/jgp.201711968

Article

Ligand-induced structural rearrangements in TRPA1

Amrita Samanta; Janna Kiselar; Ruth A. Pumroy; Seungil Han; Vera Y. Moiseenkova-Bell

https://doi.org/10.1085/jgp.201711876

Article

Different agonists evoke distinct structural changes

Nuriya Mukhtasimova; Steven M. Sine

https://doi.org/10.1085/jgp.201711881

Article

Altered fast and slow gating elicited by Cx26G12R

Isaac E. García; Felipe Villanelo; Gustavo F. Contreras; Amaury Pupo; Bernardo I. Pinto; Jorge E. Contreras; Tomás Pérez-Acle; Osvaldo Alvarez; Ramon Latorre; Agustín D. Martínez; Carlos González

https://doi.org/10.1085/jgp.201711782

Article

Tuning of a potassium-channel modulator

Malin Silverå Ejneby; Xiongyu Wu; Nina E. Ottosson; E. Peter Münger; Ingemar Lundström; Peter Konradsson; Fredrik Elinder

https://doi.org/10.1085/jgp.201711965

Article

Intrinsic ligand regulates KCNH channels

Gucan Dai; Zachary M. James; William N. Zagotta

https://doi.org/10.1085/jgp.201711989

Methods and Approaches

Reconstitution of ion channels from nanodiscs

Laura-Marie Winterstein; Kerri Kukovetz; Oliver Rauh; Daniel L. Turman; Christian Braun; Anna Moroni; Indra Schroeder; Gerhard Thiel