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Journal Articles

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Yichen Liu, Cesar A. Amaya-Rodriguez, Victoria Collio, Gabriel Ibañez, Ramón Latorre, Francisco Bezanilla
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (4): e202613980.
https://doi.org/10.1085/jgp.202613980
Published: 07 May 2026
View article titled, Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era
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Journal Articles

A sodium channel mutant removes fast inactivation with the inactivation particle bound

In Special Collection:
JGP Highlights Collection 2025
Yichen Liu, Francisco Bezanilla
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413667.
https://doi.org/10.1085/jgp.202413667
Published: 27 November 2024
View article titled, A sodium channel mutant removes fast inactivation with the inactivation particle bound
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Includes: Supplementary data
Journal Articles

Methodological improvements for fluorescence recordings in Xenopus laevis oocytes

Elizabeth E.L. Lee, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (2): 264–272.
https://doi.org/10.1085/jgp.201812189
Published: 03 January 2019
View article titled, Methodological improvements for fluorescence recordings in Xenopus laevis oocytes
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Includes: Supplementary data
Journal Articles

Influences: The Cell Physiology Laboratory in Montemar, Chile

Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2018) 150 (11): 1464–1468.
https://doi.org/10.1085/jgp.201812157
Published: 19 October 2018
View article titled, Influences: The Cell Physiology Laboratory in Montemar, Chile
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Journal Articles

Gating currents

Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2018) 150 (7): 911–932.
https://doi.org/10.1085/jgp.201812090
Published: 25 June 2018
View article titled, Gating currents
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Journal Articles

Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape

In Special Collection:
Ion Channels in the Era of Precision Biology 2018 , Molecular Biophysics of Membranes 2018
Daniel T. Infield, Elizabeth E.L. Lee, Jason D. Galpin, Grace D. Galles, Francisco Bezanilla, Christopher A. Ahern
Journal: Journal of General Physiology
J Gen Physiol (2018) 150 (7): 1017–1024.
https://doi.org/10.1085/jgp.201812075
Published: 04 June 2018
View article titled, Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape
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Includes: Supplementary data
Journal Articles

Nonsensing residues in S3–S4 linker’s C terminus affect the voltage sensor set point in K+ channels

In Special Collection:
Ion Channel Structure & Function 2018 , Ion Channels in the Era of Precision Biology 2018 , Molecular Biophysics of Membranes 2018
Joao L. Carvalho-de-Souza, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2018) 150 (2): 307–321.
https://doi.org/10.1085/jgp.201711882
Published: 10 January 2018
View article titled, Nonsensing residues in S3–S4 linker’s C terminus affect the voltage sensor set point in K+ channels
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Journal Articles

The gating charge should not be estimated by fitting a two-state model to a Q-V curve

Francisco Bezanilla, Carlos A. Villalba-Galea
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (6): 575–578.
https://doi.org/10.1085/jgp.201311056
Published: 11 November 2013
View article titled, The gating charge should not be estimated by fitting a two-state model to a Q-V curve
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Journal Articles

Sensing charges of the Ciona intestinalis voltage-sensing phosphatase

Carlos A. Villalba-Galea, Ludivine Frezza, Walter Sandtner, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (5): 543–555.
https://doi.org/10.1085/jgp.201310993
Published: 14 October 2013
View article titled, Sensing charges of the Ciona intestinalis voltage-sensing phosphatase
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Includes: Supplementary data
Journal Articles

Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels

Deborah L. Capes, Marcel P. Goldschen-Ohm, Manoel Arcisio-Miranda, Francisco Bezanilla, Baron Chanda
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (2): 101–112.
https://doi.org/10.1085/jgp.201310998
Published: 15 July 2013
View article titled, Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels
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Journal Articles

Intermediate state trapping of a voltage sensor

Jérôme J. Lacroix, Stephan A. Pless, Luca Maragliano, Fabiana V. Campos, Jason D. Galpin, Christopher A. Ahern, Benoît Roux, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2012) 140 (6): 635–652.
https://doi.org/10.1085/jgp.201210827
Published: 26 November 2012
View article titled, Intermediate state trapping of a voltage sensor
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Includes: Supplementary data
Journal Articles

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

Ernesto Vargas, Vladimir Yarov-Yarovoy, Fatemeh Khalili-Araghi, William A. Catterall, Michael L. Klein, Mounir Tarek, Erik Lindahl, Klaus Schulten, Eduardo Perozo, Francisco Bezanilla, Benoît Roux
Journal: Journal of General Physiology
J Gen Physiol (2012) 140 (6): 587–594.
https://doi.org/10.1085/jgp.201210873
Published: 26 November 2012
View article titled, An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations
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Includes: Supplementary data
Journal Articles

Molecular mechanism for depolarization-induced modulation of Kv channel closure

Alain J. Labro, Jerome J. Lacroix, Carlos A. Villalba-Galea, Dirk J. Snyders, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2012) 140 (5): 481–493.
https://doi.org/10.1085/jgp.201210817
Published: 15 October 2012
View article titled, Molecular mechanism for depolarization-induced modulation of Kv channel closure
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Journal Articles

The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers

Dominique G. Gagnon, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2010) 136 (5): 555–568.
https://doi.org/10.1085/jgp.201010487
Published: 25 October 2010
View article titled, The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers
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Includes: Supplementary data
Journal Articles

Coupling between the voltage-sensing and phosphatase domains of Ci-VSP

Carlos A. Villalba-Galea, Francesco Miceli, Maurizio Taglialatela, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2009) 134 (1): 5–14.
https://doi.org/10.1085/jgp.200910215
Published: 29 June 2009
View article titled, Coupling between the voltage-sensing and phosphatase domains of Ci-VSP
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Journal Articles

A single charged voltage sensor is capable of gating the Shaker K+ channel

Dominique G. Gagnon, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2009) 133 (5): 467–483.
https://doi.org/10.1085/jgp.200810082
Published: 27 April 2009
View article titled, A single charged voltage sensor is capable of gating the Shaker K+ channel
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Includes: Supplementary data
Journal Articles

α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels

Fabiana V. Campos, Baron Chanda, Paulo S.L. Beirão, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2008) 132 (2): 251–263.
https://doi.org/10.1085/jgp.200809995
Published: 28 July 2008
View article titled, α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels
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Journal Articles

β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel

Fabiana V. Campos, Baron Chanda, Paulo S.L. Beirão, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2007) 130 (3): 257–268.
https://doi.org/10.1085/jgp.200609719
Published: 13 August 2007
View article titled, β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel
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Journal Articles

Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy Reveals the Existence of Two Gates for Ion Conduction

Rikard Blunck, Julio F. Cordero-Morales, Luis G. Cuello, Eduardo Perozo, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (5): 569–581.
https://doi.org/10.1085/jgp.200609638
Published: 16 October 2006
View article titled, Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy Reveals the Existence of Two Gates for Ion Conduction
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Journal Articles

The Origin of Subconductance Levels in Voltage-gated K+ Channels

Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2005) 126 (2): 83–86.
https://doi.org/10.1085/jgp.200509352
Published: 25 July 2005
View article titled, The Origin of Subconductance Levels in Voltage-gated K+ Channels
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