Issues

This JGP study reveals that in addition to voltage-gated Ca²⁺ and K⁺ channels, ω-grammotoxin-SIA also inhibits voltage-gated Na⁺ channel currents.

New RLC-1 small-molecule inhibits actomyosin interactions, reduces contractile force, and speeds up myosin cross-bridge kinetics.

Rad is an emerging key Ca_v1.2 modulator. In the present issue of JGP, Elmore, Ahern et al. examine how the Rad C-terminus affects its subcellular distribution and Ca_v1.2 regulation.

This tutorial provides the ideas and information needed to understand, at a basic level, the application of convolutional neural networks to analyze images in biology and traces a path to adopting the available applications of machine learning to biology research.

Lewis and Griffith review developments in ion channels of cold transduction and transmission.

The ω-grammotoxin-SIA peptide (GrTx-SIA) was originally found in tarantula venom and shown to inhibit voltage-gated Ca²⁺ channels. Here, Collaço et al. report that GrTx-SIA can also potently inhibit voltage-gated Na⁺ channel currents, with Na_V1.6 being the most susceptible subtype.

Kooiker et al. investigate the mechanisms of a novel cardiac myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC-1). They show that RLC-1 destabilizes myosin interactions to inhibit force and accelerate kinetics in cardiac muscle.

Using a mathematical model, Stephenson tests the hypothesis that the characteristic response to Ca²⁺ of RyR channels is key not only for the Ca²⁺ release mechanism in cardiac muscle and other tissues, but also for the DHPR-dependent Ca²⁺ release in skeletal muscles.

Mott et al. evaluate two click-chemistry protein labeling tools based on genetic code expansion technology and circularly permutated Halotag, respectively, for their utility in TRPV1 cell surface expression studies.