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Two JGP studies reveal how small differences in a pore-lining region alter both the gap junction and hemichannel function of connexin26 and connexin30.

Commentary

The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.

Viewpoint

The advent of large language models and their indiscriminate use to speed up the production of papers threatens to worsen the already dysfunctional state of the scientific literature and its publishing industry.

Articles

Two connexins, Cx26 and Cx30, are expressed in the cochlea and play vital roles in hearing. Sanchez et al. identified a sequence difference in their E1 domains that differentially affects their abilities to operate as hemichannnels and function in transmembrane signaling.

Kraujaliene et al. used modeling and dye uptake/transfer studies to show that an Ala/Glu difference in the E1 domains of Cx26 and Cx30 can account for their differential permeabilities to anionic permeants. The permeability profiles are conserved in gap junction channels and hemichannel configurations.

Voltage-Gated Na Channels

Vasylyev et al. show that the Na+ channel Nav1.8 amplifies DRG neuron excitability close to the activation potential threshold, while Nav1.7 acts closer to resting potential. Their findings suggest that full inhibition of Nav1.8 may not be required for the relief of pain due to DRG neuron hyperexcitability.

Communications

Mohran et al. show that calcium has a direct effect on thick filament activation in myocardium rather than an indirect effect due to calcium-mediated crosstalk between the thick and thin filaments. Their findings should be considered in developing future drug candidates to treat heart diseases.

Cyclic AMP levels can be increased in the rod outer segment by 30–60% within the first second of light exposure before returning to baseline levels. Chernyshkova et al. show that a short increase in cAMP results in PKA activation and that proteins ∼70 kDa are the major targets of the phospho-PKA substrate antibody.

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