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Volume 141, Issue 4

1 April 2013

Journal of General Physiology Cover Image for Volume 141, Issue 4

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Cover Image

Cover Image

Cover picture: Transport phenotypes of EcClC and its point mutants as observed in solid-supported membrane electrophysiology experiments. WT, the stoichiometric 2Cl⁻/1H⁺ exchange of EcClC; WT/DIDS, the irreversible inhibition by covalent binding of DIDS from the intracellular side; E148A, uncoupled Cl⁻ permeation in a mutant of the external H⁺ acceptor; E203Q, the pH dependence of uncoupled Cl⁻ permeation in a mutant of the internal H⁺ acceptor (see Methods and Approaches by Garcia-Celma et al., 479–491).
Table of Contents
Editorial Board

ISSN 0022-1295

EISSN 1540-7748

In this Issue

Editorial
Generally Physiological
Commentary
Article
Methods and Approaches
Communication
Letter to the Editor

Editorial

New mandates? No problem for The Rockefeller University Press

Mike Rossner

View Articletitled, New mandates? No problem for The Rockefeller University Press

Generally Physiological

Looking to the past and to the future

Elizabeth M. Adler

View Articletitled, Looking to the past and to the future

Commentary

The where and how of PIP regulation of cone photoreceptor CNG channels

Lei Zhou,Diomedes E. Logothetis

View Articletitled, The where and how of PIP regulation of cone photoreceptor CNG channels

The electric heart of hERG

León D. Islas

View Articletitled, The electric heart of hERG

Article

Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides

Gucan Dai,Changhong Peng,Chunming Liu,Michael D. Varnum

View Articletitled, Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides

Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

Zhuren Wang,Ying Dou,Samuel J. Goodchild,Zeineb Es-Salah-Lamoureux,David Fedida

View Articletitled, Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

Construction and validation of a homology model of the human voltage-gated proton channel hH_V1

Kethika Kulleperuma,Susan M.E. Smith,Deri Morgan,Boris Musset,John Holyoake,Nilmadhab Chakrabarti,Vladimir V. Cherny,Thomas E. DeCoursey,Régis Pomès

View Articletitled, Construction and validation of a homology model of the human voltage-gated proton channel hH<sub>V</sub>1

Loop C and the mechanism of acetylcholine receptor–channel gating

Prasad Purohit,Anthony Auerbach

View Articletitled, Loop C and the mechanism of acetylcholine receptor–channel gating

Methods and Approaches

Functional characterization of a ClC transporter by solid-supported membrane electrophysiology

Juan Garcia-Celma,Adrian Szydelko,Raimund Dutzler

View Articletitled, Functional characterization of a ClC transporter by solid-supported membrane electrophysiology

Communication

Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers

Yanyan Geng,Xiaoyu Wang,Karl L. Magleby

View Articletitled, Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers

Ca²⁺ block and flickering both contribute to the negative slope of the IV curve in BK channels

Indra Schroeder,Gerhard Thiel,Ulf-Peter Hansen

View Articletitled, Ca<sup>2+</sup> block and flickering both contribute to the negative slope of the IV curve in BK channels

Letter to the Editor

Using hierarchical thermodynamic linkage analysis to study ion channel gating

Tzilhav Shem-Ad,Ofer Yifrach

View Articletitled, Using hierarchical thermodynamic linkage analysis to study ion channel gating

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JGP 100th Anniversary

Carriers, exchangers, and cotransporters in the first 100 years of the Journal of General Physiology

The physical basis of osmosis

Voltage-Gated Na Channels

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Mechanotransduction by Membrane Proteins

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

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