Issues

Cover picture: Adenoviral expression of mitochondria-targeted inorganic polyphosphate (polyP)-hydrolyzing exopolyphosphatase (PPX) was used to reduce polyP levels (top right image) and to investigate the role of polyP for mitochondrial permeability transition pore regulation in cardiac myocytes. DAPI staining revealed mitochondrial polyP localization (bottom right image), polyP-dependent fluorescence (bottom left), and a significant reduction in polyP levels in exopolyphosphataseexpressing cells (bottom right). GFP expression served as a control to monitor the structural effects of PPX expression (see article by Seidlmayer et al., 321–331).