Issues

Cover picture: The TRPV1 channel’s pore turret is important for heat-induced activation. Changes in the turret sequence (top left) do not cause major changes in the protein’s targeting to the plasma membrane (bottom left) nor to its sensitivity to capsaicin (bottom right). However, heat-induced activation was significantly altered (top right), suggesting a specific role for the turret in heat activation (see article by Cui et al., 273–283).