1 August 2009
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Cover Image
Cover Image
Cover picture: Point mutations that cause the CNGA1 channel to become voltage-gated are clustered around the ion selectivity filter. (Top and Middle) Alanine substitutions at red- and yellow-colored positions produce channels with strongly and modestly voltage-gated currents, respectively, whereas those at blue-colored positions yield unmeasurable currents. The remaining mutations produce non-voltage–gated currents. (Bottom) Degree of voltage gating of mutant channels, expressed as the ratio of current at two holding potentials (I200 /I−200 or I200 /I10) (see article by Martínez-François et al., 151–164).
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ISSN 0022-1295
EISSN 1540-7748
