Issues

Cover picture: Evolution of retinol fluorescence in bleached rod photoreceptors. (Top) After pigment bleaching, fluorescence reflecting all-trans retinol generated by reduction of all-trans retinal is initially measurable at the base of the outer segment and gradually progresses to the tip. (Bottom) A model whereby reduction cofactor NADPH is generated in the ellipsoid region of the inner segment and diffuses along the outer segment can explain the observed fluorescence pattern (see article by Miyagishima et al., 165–175).