Issues

Cover picture: Structural model of a two-pore domain potassium channel: K2P Ø viewed from the cytoplasm. The channel is composed of two subunits (purple and blue) with a bilaterally symmetric cytoplasmic cavity and fourfold symmetric selectivity filter. Wild-type currents (left) are inhibited by introduction of a charge at the bottom of the selectivity filter (middle, +), and positions were then identified where addition of a countercharge restored channel function (right, −) (see article by Kollewe et al., 53–68).