Issues

Cover picture: Retinal photoreceptor metabolism increases in the dark, leading to increased deposition of CO₂ and water into the subretinal space (SRS). The retinal pigment epithelium can mitigate this potentially catastrophic metabolic load by increasing CO₂/HCO₃, Na, and H₂O absorption from the SRS into the choroidal blood supply via Na-linked HCO₃ transporters, thus preventing SRS acidosis and retinal detachment (see article by Adijanto et al., 603–622).