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Journal Articles

Bridging the gap between tumor and disease: Innovating cancer and glioma models

Stefano M. Cirigliano, Howard A. Fine
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20220808.
https://doi.org/10.1084/jem.20220808
Published: 03 December 2024
View article titled, Bridging the gap between tumor and disease: Innovating cancer and glioma models
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Journal Articles

Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer

Camila Robles-Oteíza, Katherine Hastings, Jungmin Choi, Isabelle Sirois, Arvind Ravi, Francisco Expósito, Fernando de Miguel, James R. Knight, Francesc López-Giráldez, Hyejin Choi, Nicholas D. Socci, Taha Merghoub, Mark Awad, Gad Getz, Justin Gainor, Matthew D. Hellmann, Étienne Caron, Susan M. Kaech, Katerina Politi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20231106.
https://doi.org/10.1084/jem.20231106
Published: 25 November 2024
View article titled, Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer
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Includes: Supplementary data
Journal Articles

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20231967.
https://doi.org/10.1084/jem.20231967
Published: 21 November 2024
View article titled, Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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Includes: Supplementary data
Journal Articles

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Xue Li, Han Yi, Zheyu Jin, Kaitao Jiang, Kangkang Xue, Jin Wang, Yuping Qian, Qian Xiang, Sijing Zhu, Runhe Yan, Yulong Yang, Shenfei Sun, Kai Li, Zichu Zhou, Wei Yu, Ning Jiang, Chen Ding, Xinhua Lin, Jiang Zhong, Yuchao Dong, Yanfang Liu, Xiaofei Yu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240959.
https://doi.org/10.1084/jem.20240959
Published: 15 November 2024
View article titled, MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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Includes: Supplementary data
Journal Articles

IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation

Che-Chia Hsu, Guihua Wang, Chien-Feng Li, Xian Zhang, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gu, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhongzhu Chen, Ming Chen, Andrew J. Armstrong, Jiaoti Huang, Hong-Yu Li, Hui-Kuan Lin
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231832.
https://doi.org/10.1084/jem.20231832
Published: 29 October 2024
View article titled, IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation
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Includes: Supplementary data
Journal Articles

NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer

Daiyong Deng, Habeebunnisa Begum, Tong Liu, Jiangyan Zhang, Qiang Zhang, Ting-yu Chu, Hong Li, Alexander Lemenze, Mainul Hoque, Patricia Soteropoulos, Pingping Hou
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240766.
https://doi.org/10.1084/jem.20240766
Published: 21 October 2024
View article titled, NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer
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Includes: Supplementary data
Journal Articles

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

Ian W. Folkert, William A. Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S. Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J. Lazar, Khalida Wani, William P. Israel, Zhan Zhang, Venkata S. Chaluvadi, Robert J. Norgard, Ying Liu, Ashley M. Fuller, Mai T. Dang, Robert E. Roses, Giorgos C. Karakousis, John T. Miura, Douglas L. Fraker, T.S. Karin Eisinger-Mathason, M. Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20230420.
https://doi.org/10.1084/jem.20230420
Published: 30 September 2024
View article titled, An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis
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Includes: Supplementary data
Journal Articles

Aberrant pre-mRNA processing in cancer

Jeetayu Biswas, Leora Boussi, Eytan Stein, Omar Abdel-Wahab
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (11): e20230891.
https://doi.org/10.1084/jem.20230891
Published: 24 September 2024
View article titled, Aberrant pre-mRNA processing in cancer
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Journal Articles

Inhibition of hTERT/telomerase/telomere mediates therapeutic efficacy of osimertinib in EGFR mutant lung cancer

Zhen Chen, Karin A. Vallega, Dongsheng Wang, Zihan Quan, Songqing Fan, Qiming Wang, Ticiana Leal, Suresh S. Ramalingam, Shi-Yong Sun
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240435.
https://doi.org/10.1084/jem.20240435
Published: 19 September 2024
View article titled, Inhibition of hTERT/telomerase/telomere mediates therapeutic efficacy of osimertinib in EGFR mutant lung cancer
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Includes: Supplementary data
Journal Articles

Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer

In Special Collection:
Cytokines Collection 2024
Apostolia M. Tsimberidou, Farah A. Alayli, Kwame Okrah, Alexandra Drakaki, Danny N. Khalil, Shivaani Kummar, Saad A. Khan, F. Stephen Hodi, David Y. Oh, Christopher R. Cabanski, Shikha Gautam, Stefanie L. Meier, Meelad Amouzgar, Shannon M. Pfeiffer, Robin Kageyama, EnJun Yang, Marko Spasic, Michael T. Tetzlaff, Wai Chin Foo, Travis J. Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S. Moore, Sharlene Velichko, Richard O. Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M. Hubbard-Lucey, Jill O’Donnell-Tormey, Sandra Santulli-Marotto, Lisa H. Butterfield, Diane M. Da Silva, Justin Fairchild, Theresa M. LaVallee, Lacey J. Padrón, Padmanee Sharma
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240152.
https://doi.org/10.1084/jem.20240152
Published: 27 August 2024
View article titled, Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer
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Includes: Supplementary data
Journal Articles

Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

Naijun Miao, Dongqing Cao, Jingsi Jin, Guizhi Ma, Haihui Yu, Junwen Qu, Guiping Li, Caixia Gao, Dong Dong, Fan Xia, Wenwen Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231486.
https://doi.org/10.1084/jem.20231486
Published: 21 August 2024
View article titled, Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8<sup>+</sup> T cell stemness maintenance
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Includes: Supplementary data
Journal Articles

The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes

In Special Collection:
Mechanisms and Models of Cancer 2024
Mark Esposito, John K. Amory, Yibin Kang
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (9): e20240519.
https://doi.org/10.1084/jem.20240519
Published: 12 August 2024
View article titled, The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
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Journal Articles

Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis

In Special Collection:
Mechanisms and Models of Cancer 2024
Lingzi Hong, Tomasz Herjan, Xing Chen, Leah L. Zagore, Katarzyna Bulek, Han Wang, Chi-Fu Jeffrey Yang, Donny D. Licatalosi, Xiaoxia Li, Xiao Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20231442.
https://doi.org/10.1084/jem.20231442
Published: 11 June 2024
View article titled, Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis
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Includes: Supplementary data
Journal Articles

Personalized cancer T-cell therapy takes the stage, mirroring vaccine success

Johanna Chiffelle, Alexandre Harari
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (8): e20240854.
https://doi.org/10.1084/jem.20240854
Published: 11 June 2024
View article titled, Personalized cancer T-cell therapy takes the stage, mirroring vaccine success
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Journal Articles

Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment

In Special Collection:
Mechanisms and Models of Cancer 2024
Michelle A. Tran, Dina Youssef, Sanjana Shroff, Disha Chowhan, Kristin G. Beaumont, Robert Sebra, Reza Mehrazin, Peter Wiklund, Jenny J. Lin, Amir Horowitz, Adam M. Farkas, Matthew D. Galsky, John P. Sfakianos, Nina Bhardwaj
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (8): e20240045.
https://doi.org/10.1084/jem.20240045
Published: 07 June 2024
View article titled, Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment
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Includes: Supplementary data
Journal Articles

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

In Special Collection:
Immunometabolism 2024 , Mechanisms and Models of Cancer 2024
Yun Xue, Yuting Chen, Sijia Sun, Xinyuan Tong, Yujia Chen, Shijie Tang, Xue Wang, Simin Bi, Yuqin Qiu, Qiqi Zhao, Zhen Qin, Qin Xu, Yingjie Ai, Leilei Chen, Beizhen Zhang, Zhijie Liu, Minbiao Ji, Meidong Lang, Luonan Chen, Guoliang Xu, Liang Hu, Dan Ye, Hongbin Ji
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20240111.
https://doi.org/10.1084/jem.20240111
Published: 28 May 2024
View article titled, TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition
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Includes: Supplementary data
Journal Articles

Hormonal basis of brain fog in cancer treatment

In Special Collection:
Neuroscience Collection 2024
Yuan Pan, Jian Hu
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (5): e20231942.
https://doi.org/10.1084/jem.20231942
Published: 10 April 2024
View article titled, Hormonal basis of brain fog in cancer treatment
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Journal Articles

Divergent local and systemic antitumor response in primary uveal melanomas

In Special Collection:
Mechanisms and Models of Cancer 2024
Francesca Lucibello, Ana I. Lalanne, Anne-Laure Le Gac, Abdoulaye Soumare, Setareh Aflaki, Joanna Cyrta, Lea Dubreuil, Martin Mestdagh, Marion Salou, Alexandre Houy, Christina Ekwegbara, Camille Jamet, Sophie Gardrat, Anais Le Ven, Karine Bernardeau, Nathalie Cassoux, Alexandre Matet, Denis Malaise, Gaelle Pierron, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues, Olivier Lantz
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (6): e20232094.
https://doi.org/10.1084/jem.20232094
Published: 02 April 2024
View article titled, Divergent local and systemic antitumor response in primary uveal melanomas
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Includes: Supplementary data
Journal Articles

ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype

In Special Collection:
JEM Cancer Collection 2024
Naveen Sharma, Xiaozhou Fan, Oluwatomisin T. Atolagbe, Zhongqi Ge, Kelly N. Dao, Padmanee Sharma, James P. Allison
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20231263.
https://doi.org/10.1084/jem.20231263
Published: 22 March 2024
View article titled, ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype
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Includes: Supplementary data
Journal Articles

Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds

In Special Collection:
Mechanisms and Models of Cancer 2024
Yuanyuan Zhao, Bing Zhang, Yiming Ma, Mengmeng Guo, Fuqiang Zhao, Jianan Chen, Bingzhi Wang, Hua Jin, Fulai Zhou, Jiawei Guan, Qian Zhao, Qian Liu, Hongying Wang, Fangqing Zhao, Xia Wang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20231359.
https://doi.org/10.1084/jem.20231359
Published: 19 March 2024
View article titled, Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds
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Includes: Supplementary data