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Journal Articles

Myeloid-targeting immunotherapies overcome inhibitory barriers in immune-evasive neuroblastoma

Marie Ménard, Hiroyuki Yoda, Nicole Nasholm, Megumi J. Barata, Linyu Wang, Erin F. Simonds, Edbert D. Lu, Shannon Wong-Michalak, Lauren McHenry, Alvin Farrel, Rebecca Kaufman, Vanessa Lopez, Rebekah J. Kennedy, G. Esteban Fernandez, Hiroyuki Shimada, Liron D. Grossmann, Shahab Asgharzadeh, John M. Maris, W. Clay Gustafson, William A. Weiss
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20231417.
https://doi.org/10.1084/jem.20231417
Published: 14 July 2025
View article titled, Myeloid-targeting immunotherapies overcome inhibitory barriers in immune-evasive neuroblastoma
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Includes: Supplementary data
Journal Articles

Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting

Aneesha Dasgupta, Rebecca E. Schmitt, Tatsuyoshi Kono, Chih-Chun Lee, Mark I. Zoberi, Savannah A. Epstein, Jessica Z. Schneider, Alejandro Hernandez, Paul M. Grandgenett, Thomas C. Caffrey, Dominick J. DiMaio, Michael A. Hollingsworth, Jason D. Doles
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20242239.
https://doi.org/10.1084/jem.20242239
Published: 02 July 2025
View article titled, Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting
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Journal Articles

Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control

Kun Peng, Xiaoxue Zhao, Hongjian Li, Yang-Xin Fu, Yong Liang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241454.
https://doi.org/10.1084/jem.20241454
Published: 06 June 2025
View article titled, Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control
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Journal Articles

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation

Chae Won Kim, Hyun-Jin Kim, In Kang, Keun Bon Ku, Yumin Kim, Jang Hyun Park, Juhee Lim, Byeong Hoon Kang, Won Hyung Park, Jeongwoo La, Sungwoo Chang, Inju Hwang, Minji Kim, Stephen Ahn, Heung Kyu Lee
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241135.
https://doi.org/10.1084/jem.20241135
Published: 22 May 2025
View article titled, Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
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Includes: Supplementary data
Journal Articles

A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo

Fanghui Zhang, Javier Celis-Gutierrez, Lichen Zhang, Valentin Mellado, Léna Gelard, Sophie Panigot, Daiki Mori, Liaoxun Lu, Guillaume Voisinne, Carine Vilarnau Wolek, Marielle Mello, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Frédéric Fiore, Romain Roncagalli, Yinming Liang, Marie Malissen, Bernard Malissen
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250339.
https://doi.org/10.1084/jem.20250339
Published: 22 May 2025
View article titled, A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
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Includes: Supplementary data
Journal Articles

Sympathetic axonogenesis promotes adenoid cystic carcinoma progression

In Special Collection:
Neuroimmunology and Neurodegeneration 2025
Chun-Hao Chen, Boris Reva, Nora Katabi, Avishai Wizel, Hongbo Xu, Alan L. Ho, Luc G.T. Morris, Richard L. Bakst, Anuraag S. Parikh, Yotam Drier, Sylvie Deborde, Richard J. Wong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20242250.
https://doi.org/10.1084/jem.20242250
Published: 24 April 2025
View article titled, Sympathetic axonogenesis promotes adenoid cystic carcinoma progression
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Includes: Supplementary data
Journal Articles

PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion

In Special Collection:
Immunometabolism 2025
Wenxing Qin, Yuran Duan, Zhiqiang Hu, Yueru Hou, Ting Wen, Yuan Ouyang, Zheng Wang, Xue Sun, Xiaohan Chen, Katherine L. Wang, Shudi Luo, Guimei Ji, Yuli Shen, Bofei Dong, Yanni Lin, Qi Tian, Zhanpeng Guo, Shiqi Wu, Ling Xiao, Min Li, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Wuchang Zhang, Shengzhong Duan, Xueli Bai, Tong Liu, Jie He, Zhimin Lu, Daqian Xu
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20240902.
https://doi.org/10.1084/jem.20240902
Published: 06 March 2025
View article titled, PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion
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Includes: Supplementary data
Journal Articles

Splicing factor RBM10 loss fuels thyroid cancer metastasis

Kevin Coughlin, Jr., Ledong Wan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20250050.
https://doi.org/10.1084/jem.20250050
Published: 24 February 2025
View article titled, Splicing factor RBM10 loss fuels thyroid cancer metastasis
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Journal Articles

RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs

Gnana P. Krishnamoorthy, Anthony R. Glover, Brian R. Untch, Nickole Sigcha-Coello, Bin Xu, Dina Vukel, Yi Liu, Vera Tiedje, Jose Mario Bello Pineda, Katherine Berman, Prasanna P. Tamarapu, Adrian Acuña-Ruiz, Mahesh Saqcena, Elisa de Stanchina, Laura Boucai, Ronald A. Ghossein, Jeffrey A. Knauf, Omar Abdel-Wahab, Robert K. Bradley, James A. Fagin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241029.
https://doi.org/10.1084/jem.20241029
Published: 24 February 2025
View article titled, RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs
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Includes: Supplementary data
Journal Articles

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39

In Special Collection:
JEM Cancer Collection 2025 , JEM Clinical Immunology Collection 2025
Sang-Nee Tan, Jing Hao, Jing Ge, Yazheng Yang, Liguo Liu, Jia Huang, Meng Lin, Xiaohong Zhao, Genyu Wang, Zhiying Yang, Ling Ni, Chen Dong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20240445.
https://doi.org/10.1084/jem.20240445
Published: 05 February 2025
View article titled, Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39
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Includes: Supplementary data
Journal Articles

Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis

Shan-Shan Wang, Jia Yuan, Xinyu Thomas Tang, Xiujuan Yin, Ke Fang, Lin Veronica Chen, Zhenggang Ren, Bo O. Zhou
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20232123.
https://doi.org/10.1084/jem.20232123
Published: 31 January 2025
View article titled, Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis
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Journal Articles

PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers

Ying He, Wei Li, Meiling Zhang, Hui Wang, Peilu Lin, Ying Yu, Bin Huang, Meng Hao, Jianuo He, Weiyao Kong, Dan Luo, Tengteng Xu, Jiaqi Wang, Ying Huang, Qinwen Zhao, Ying Liu, Jie Zhang, Yong Nian, Lei Zhang, Bo Zhu, Chengqian Yin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20241147.
https://doi.org/10.1084/jem.20241147
Published: 22 January 2025
View article titled, PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers
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Includes: Supplementary data
Journal Articles

A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis

Emily L. Ashkin, Yuning J. Tang, Haiqing Xu, King L. Hung, Julia A. Belk, Hongchen Cai, Steven S. Lopez, Deniz Nesli Dolcen, Jess D. Hebert, Rui Li, Paloma A. Ruiz, Tula Keal, Laura Andrejka, Howard Y. Chang, Dmitri A. Petrov, Jesse R. Dixon, Zhichao Xu, Monte M. Winslow
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240765.
https://doi.org/10.1084/jem.20240765
Published: 09 December 2024
View article titled, A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
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Includes: Supplementary data
Journal Articles

Bridging the gap between tumor and disease: Innovating cancer and glioma models

In Special Collection:
JEM Cancer Collection 2025
Stefano M. Cirigliano, Howard A. Fine
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20220808.
https://doi.org/10.1084/jem.20220808
Published: 03 December 2024
View article titled, Bridging the gap between tumor and disease: Innovating cancer and glioma models
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Journal Articles

Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer

In Special Collection:
JEM Cancer Collection 2025 , Tumor Metabolism 2025
Camila Robles-Oteíza, Katherine Hastings, Jungmin Choi, Isabelle Sirois, Arvind Ravi, Francisco Expósito, Fernando de Miguel, James R. Knight, Francesc López-Giráldez, Hyejin Choi, Nicholas D. Socci, Taha Merghoub, Mark Awad, Gad Getz, Justin Gainor, Matthew D. Hellmann, Étienne Caron, Susan M. Kaech, Katerina Politi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20231106.
https://doi.org/10.1084/jem.20231106
Published: 25 November 2024
View article titled, Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer
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Includes: Supplementary data
Journal Articles

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20231967.
https://doi.org/10.1084/jem.20231967
Published: 21 November 2024
View article titled, Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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Includes: Supplementary data
Journal Articles

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Xue Li, Han Yi, Zheyu Jin, Kaitao Jiang, Kangkang Xue, Jin Wang, Yuping Qian, Qian Xiang, Sijing Zhu, Runhe Yan, Yulong Yang, Shenfei Sun, Kai Li, Zichu Zhou, Wei Yu, Ning Jiang, Chen Ding, Xinhua Lin, Jiang Zhong, Yuchao Dong, Yanfang Liu, Xiaofei Yu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240959.
https://doi.org/10.1084/jem.20240959
Published: 15 November 2024
View article titled, MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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Includes: Supplementary data
Journal Articles

IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation

In Special Collection:
JEM Cancer Collection 2025 , Immunometabolism 2025 , Tumor Metabolism 2025
Che-Chia Hsu, Guihua Wang, Chien-Feng Li, Xian Zhang, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gu, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhongzhu Chen, Ming Chen, Andrew J. Armstrong, Jiaoti Huang, Hong-Yu Li, Hui-Kuan Lin
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231832.
https://doi.org/10.1084/jem.20231832
Published: 29 October 2024
View article titled, IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation
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Includes: Supplementary data
Journal Articles

NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer

Daiyong Deng, Habeebunnisa Begum, Tong Liu, Jiangyan Zhang, Qiang Zhang, Ting-yu Chu, Hong Li, Alexander Lemenze, Mainul Hoque, Patricia Soteropoulos, Pingping Hou
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240766.
https://doi.org/10.1084/jem.20240766
Published: 21 October 2024
View article titled, NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer
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Includes: Supplementary data
Journal Articles

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

In Special Collection:
JEM Cancer Collection 2025 , Immunometabolism 2025 , Tissue Microenvironment and Immune Memory , Tumor Metabolism 2025 , 2024: The Year in Experimental Medicine
Ian W. Folkert, William A. Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S. Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J. Lazar, Khalida Wani, William P. Israel, Zhan Zhang, Venkata S. Chaluvadi, Robert J. Norgard, Ying Liu, Ashley M. Fuller, Mai T. Dang, Robert E. Roses, Giorgos C. Karakousis, John T. Miura, Douglas L. Fraker, T.S. Karin Eisinger-Mathason, M. Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20230420.
https://doi.org/10.1084/jem.20230420
Published: 30 September 2024
View article titled, An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis
Open the PDF for An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis in another window
Includes: Supplementary data