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Journal Articles

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Seth D. Fortmann, Blake F. Frey, Robert F. Rosencrans, Yvonne Adu-Rutledge, Edgar Ready V, Kameron V. Kilchrist, Robert S. Welner, Michael E. Boulton, Daniel R. Saban, Maria B. Grant
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20242007.
https://doi.org/10.1084/jem.20242007
Published: 22 April 2025
View articletitled, Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration
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Includes: Supplementary data
Journal Articles

Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency

András N. Spaan, Bertrand Boisson, Seth L. Masters
Journal: Journal of Experimental Medicine
Series: Genes and Immunity Focus
J Exp Med (2025) 222 (5): e20241047.
https://doi.org/10.1084/jem.20241047
Published: 15 April 2025
View articletitled, Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency
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Journal Articles

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Fanny Saidoune, Danyel Lee, Jeremy Di Domizio, Corentin Le Floc’h, Raphael Jenelten, Jérémie Le Pen, Vincent Bondet, Ana Joncic, Marie-Anne Morren, Vivien Béziat, Shen-Ying Zhang, Emmanuelle Jouanguy, Darragh Duffy, Charles M. Rice, Curdin Conrad, Jacques Fellay, Jean-Laurent Casanova, Michel Gilliet, Ahmad Yatim
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20231467.
https://doi.org/10.1084/jem.20231467
Published: 14 April 2025
View articletitled, Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains
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Includes: Supplementary data
Journal Articles

CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

Sirimuvva Tadepalli, Derek R. Clements, Hayley M. Raquer-McKay, Anja Lüdtke, Sanjana Saravanan, David Seong, Lorraine Vitek, Christopher M. Richards, Jan E. Carette, Matthias Mack, Andres Gottfried-Blackmore, Edward E. Graves, Juliana Idoyaga
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20231717.
https://doi.org/10.1084/jem.20231717
Published: 27 March 2025
View articletitled, CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy
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Includes: Supplementary data
Journal Articles

An in-depth look at lung lymphatics

David G. Jackson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20250119.
https://doi.org/10.1084/jem.20250119
Published: 19 March 2025
View articletitled, An in-depth look at lung lymphatics
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Journal Articles

Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella

Madeline J. Churchill, Ankit Pandeya, Renate Bauer, Tighe Christopher, Stefanie Krug, Roslyn Honodel, Shuchi Smita, Lindsey Warner, Bridget M. Mooney, Alexis R. Gibson, Patrick S. Mitchell, Elia D. Tait Wojno, Isabella Rauch
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20230803.
https://doi.org/10.1084/jem.20230803
Published: 13 March 2025
View articletitled, Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella
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Includes: Supplementary data
Journal Articles

KLF family members control expression of genes required for tissue macrophage identities

Kathleen Pestal, Leianna C. Slayden, Gregory M. Barton
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20240379.
https://doi.org/10.1084/jem.20240379
Published: 12 March 2025
View articletitled, KLF family members control expression of genes required for tissue macrophage identities
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Includes: Supplementary data
Journal Articles

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

Devon Jeltema, Kennady Knox, Nicole Dobbs, Zhen Tang, Cong Xing, Antonina Araskiewicz, Kun Yang, Ivan Rodriguez Siordia, Jason Matthews, Michael Cohen, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241184.
https://doi.org/10.1084/jem.20241184
Published: 19 February 2025
View articletitled, PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
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Includes: Supplementary data
Journal Articles

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer

Simon J. Cleary, Longhui Qiu, Yurim Seo, Peter Baluk, Dan Liu, Nina K. Serwas, Catherine A. Taylor, Dongliang Zhang, Jason G. Cyster, Donald M. McDonald, Matthew F. Krummel, Mark R. Looney
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241359.
https://doi.org/10.1084/jem.20241359
Published: 19 February 2025
View articletitled, Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer
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Includes: Supplementary data
Journal Articles

No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis

Antje Blumenthal, Leslie C. Domínguez Cadena
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20242285.
https://doi.org/10.1084/jem.20242285
Published: 05 February 2025
View articletitled, No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis
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Journal Articles

Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks

Juliana J. Lee, Liang Yang, Jonathan J. Kotzin, Dughan Ahimovic, Michael J. Bale, Peter A. Nigrovic, Steven Z. Josefowicz, Diane Mathis, Christophe Benoist, Immunological Genome Project Consortium
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20241207.
https://doi.org/10.1084/jem.20241207
Published: 28 January 2025
View articletitled, Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks
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Includes: Supplementary data
Journal Articles

RNase T2 restricts TLR13-mediated autoinflammation in vivo

Carlos Gomez-Diaz, Wilhelm Greulich, Benedikt Wefers, Meiyue Wang, Silvia Bolsega, Maike Effern, Daniel P. Varga, Zhe Han, Minyi Chen, Marleen Bérouti, Natascia Leonardi, Ulrike Schillinger, Bernhard Holzmann, Arthur Liesz, Axel Roers, Michael Hölzel, Marijana Basic, Wolfgang Wurst, Veit Hornung
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20241424.
https://doi.org/10.1084/jem.20241424
Published: 24 January 2025
View articletitled, RNase T2 restricts TLR13-mediated autoinflammation in vivo
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Includes: Supplementary data
Journal Articles

RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells

Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, Yun Zhang, Tatjana Reuter, Yuko Ishida, Toshikazu Kondo, Tomoki Chiba, Hiroshi Asahara, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Tsuneyasu Kaisho, Yoichi Furukawa, Eicke Latz, Kohta Nakatani, Yoshihiro Izumi, Yunzhong Nie, Hideki Taniguchi, Kensuke Miyake
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20230647.
https://doi.org/10.1084/jem.20230647
Published: 24 January 2025
View articletitled, RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells
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Includes: Supplementary data
Journal Articles

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

In Special Collection:
Tissue Microenvironment and Immune Memory
Colin Sparano, Darío Solís-Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, Caroline Mussak, Elisa Rallo, Stanislav Dergun, Gioana Litscher, Yishu Xu, Mitchell Bijnen, Christin Friedrich, Melanie Greter, Vanda Juranić Lisnić, Burkhard Becher, Georg Gasteiger, Annette Oxenius, Sonia Tugues
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20240930.
https://doi.org/10.1084/jem.20240930
Published: 18 December 2024
View articletitled, Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
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Includes: Supplementary data
Journal Articles

Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis

Yong Du, Bérénice Faz-Lopez, Marie Dominique Ah Kioon, Claire Cenac, Michael Pierides, Kimberly S. Lakin, Robert F. Spiera, Julie Chaumeil, Marie-Elise Truchetet, Jessica K. Gordon, Jean-Charles Guéry, Franck J. Barrat
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20231809.
https://doi.org/10.1084/jem.20231809
Published: 13 December 2024
View articletitled, Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis
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Includes: Supplementary data
Journal Articles

Dual role of vascular endothelial growth factor-C in post-stroke recovery

Yun Hwa Choi, Martin Hsu, Collin Laaker, Jenna Port, Kristóf G. Kovács, Melinda Herbath, Heeyoon Yang, Peter Cismaru, Alexis M. Johnson, Bailey Spellman, Kelsey Wigand, Matyas Sandor, Zsuzsanna Fabry
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20231816.
https://doi.org/10.1084/jem.20231816
Published: 12 December 2024
View articletitled, Dual role of vascular endothelial growth factor-C in post-stroke recovery
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Includes: Supplementary data
Journal Articles

CCDC134 controls TLR biogenesis through the ER chaperone Gp96

Léa Bernaleau, Michaela Drobek, Fenja Blank, Philipp Walch, Maeva Delacrétaz, Ales Drobek, Marta Monguió-Tortajada, Petr Broz, Olivia Majer, Manuele Rebsamen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20240825.
https://doi.org/10.1084/jem.20240825
Published: 10 December 2024
View articletitled, CCDC134 controls TLR biogenesis through the ER chaperone Gp96
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Includes: Supplementary data
Journal Articles

Human DBR1 deficiency impairs stress granule–dependent PKR antiviral immunity

Shuo Ru, Sisi Tang, Hui Xu, Jiahao Yin, Yan Guo, Liuping Song, Zhenyu Jin, Danyel Lee, Yi-Hao Chan, Xingyao Chen, Luke Buerer, William Fairbrother, Weidong Jia, Jean-Laurent Casanova, Shen-Ying Zhang, Daxing Gao
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240010.
https://doi.org/10.1084/jem.20240010
Published: 05 December 2024
View articletitled, Human DBR1 deficiency impairs stress granule–dependent PKR antiviral immunity
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Includes: Supplementary data
Journal Articles

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

In Special Collection:
Genes and Immunity
Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, COVID-19 Human Genetic Effort, DIAMONDS, EUCLIDS, Michael J. Carter, Paul Wellman, Mark Peters, Rebeca Pérez de Diego, Lindsey Ann Edwards, Christopher Chiu, Mahdad Noursadeghi, Alexandre Bolze, Chisato Shimizu, Myrsini Kaforou, Melissa Shea Hamilton, Jethro A. Herberg, Erica G. Schmitt, Agusti Rodriguez-Palmero, Aurora Pujol, Jihoon Kim, Aurélie Cobat, Laurent Abel, Shen-Ying Zhang, Jean-Laurent Casanova, Taco W. Kuijpers, Jane C. Burns, Michael Levin, Adrian C. Hayday, Vanessa Sancho-Shimizu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e920240699.
https://doi.org/10.1084/jem.20240699
Published: 22 November 2024
View articletitled, Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)
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Includes: Supplementary data
Journal Articles

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20231967.
https://doi.org/10.1084/jem.20231967
Published: 21 November 2024
View articletitled, Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
Open the PDF for Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer in another window
Includes: Supplementary data