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Journal Articles

Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Jiuxing Feng, Baitong Wu, Yu Li, Pengli Sun, Qian Liu, Qianxue Xiao, Jia-Bin Cai, Yimin Zheng, Haonan Chen, Yichi Xu, Yixin Liu, Guo-Ming Shi, Li Tan, Yujiang Geno Shi

J Exp Med (2025) 223 (2): e20251114.

https://doi.org/10.1084/jem.20251114

Published: 26 December 2025

View article titled, Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Includes: Supplementary data

Journal Articles

A circadian checkpoint relocates neutrophils to minimize injury

J Exp Med (2025) 223 (2): e20250240.

https://doi.org/10.1084/jem.20250240

Published: 12 December 2025

View article titled, A circadian checkpoint relocates neutrophils to minimize injury

Includes: Supplementary data

Journal Articles

XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance

Sebastian A. Stifter, Mitchell Bijnen, Selma Tuzlak, Ekaterina Petrova, Philipp Häne, Elsa Roussel, Hannah Van Hove, Kenichi Asano, Burkhard Becher, Annika Keller, Melanie Greter

J Exp Med (2025) 223 (2): e20241587.

https://doi.org/10.1084/jem.20241587

Published: 03 December 2025

View article titled, XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance

Journal Articles

SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases

J Exp Med (2025) 223 (2): e20251065.

https://doi.org/10.1084/jem.20251065

Published: 03 December 2025

View article titled, SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases

Includes: Supplementary data

Journal Articles

The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites

Mohamed R. Abdelaal, Jieru Deng, Mitchell P. McInerney, Emi Ito, Anthony W. Purcell, Sho Yamasaki, Jose A. Villadangos, Hamish E.G. McWilliam, Nicholas A. Gherardin, Jamie Rossjohn, Wael Awad

J Exp Med (2025) 223 (2): e20250711.

https://doi.org/10.1084/jem.20250711

Published: 26 November 2025

View article titled, The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites

Includes: Supplementary data

Journal Articles

SLC7A8 is essential for metabolic fitness and function of Th2 cells

Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Shitong Wu, Patrick Fernandes Rodrigues, Raki Sudan, Yizhou Liu, Haerin Jung, Intelly Lee, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna

J Exp Med (2025) 223 (2): e20250439.

https://doi.org/10.1084/jem.20250439

Published: 21 November 2025

View article titled, SLC7A8 is essential for metabolic fitness and function of Th2 cells

Journal Articles

AC/DC: Highway to cell

Victor Bosteels, William Stainier, Caetano Reis e Sousa

J Exp Med (2025) 223 (1): e20251958.

https://doi.org/10.1084/jem.20251958

Published: 13 November 2025

View article titled, AC/DC: Highway to cell

Journal Articles

Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine

Hanson Tam, Haolin Shen, Ying Xu, Jinping An, Jason G. Cyster

J Exp Med (2025) 223 (1): e20250887.

https://doi.org/10.1084/jem.20250887

Published: 10 November 2025

View article titled, Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine

Journal Articles

Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin

J Exp Med (2025) 223 (1): e20242353.

https://doi.org/10.1084/jem.20242353

Published: 04 November 2025

View article titled, Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin

Includes: Supplementary data

Journal Articles

Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity

Alexander Y. Yang, Julia Davis-Porada, Daniel H. Paik, Alex B. George, Brea H. Brown, Paige L. Ruschke, Peter A. Sims, Ziv Frankenstein, Anjali Saqi, Donna L. Farber

J Exp Med (2025) 223 (1): e20242307.

https://doi.org/10.1084/jem.20242307

Published: 13 October 2025

View article titled, Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity

Includes: Supplementary data

Journal Articles

Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity

J Exp Med (2025) 223 (1): e20250064.

https://doi.org/10.1084/jem.20250064

Published: 09 October 2025

View article titled, Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity

Includes: Supplementary data

Journal Articles

CD2 and its ligands are involved in development and activation of MAIT cells

Kaiwen Zhu, Jiayu Dou, Bin Li, Jin Qian, Ming-Chao Zhong, Zhenghai Tang, Yan Lu, André Veillette

J Exp Med (2025) 222 (12): e20250431.

https://doi.org/10.1084/jem.20250431

Published: 30 September 2025

View article titled, CD2 and its ligands are involved in development and activation of MAIT cells

Journal Articles

RIPK1 autophosphorylation at S161 mediates cell death and inflammation

In Special Collection:

Pattern Recognition Receptors and Beyond

Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, Manolis Pasparakis

J Exp Med (2025) 222 (12): e20250279.

https://doi.org/10.1084/jem.20250279

Published: 25 September 2025

View article titled, RIPK1 autophosphorylation at S161 mediates cell death and inflammation

Includes: Supplementary data

Journal Articles

RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice

In Special Collection:

Pattern Recognition Receptors and Beyond

Tao Han, Chenchen Ruan, Huiyong Lin, Yuxia Zhang, Lang Li, Ye-hsuan Sun, Chuan-Qi Zhong, Xin Chen, Kai Huang, Yating Cao, Zusen Fan, Hongbing Zhang, Jiahuai Han, Yingying Zhang

J Exp Med (2025) 222 (12): e20250277.

https://doi.org/10.1084/jem.20250277

Published: 25 September 2025

View article titled, RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice

Includes: Supplementary data

Journal Articles

DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts

In Special Collection:

Cytokines Collection 2025

Joshua Hatterschide, Liheng Yang, Carolyn B. Coyne

J Exp Med (2025) 222 (12): e20250448.

https://doi.org/10.1084/jem.20250448

Published: 18 September 2025

View article titled, DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts

Includes: Supplementary data

Journal Articles

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

In Special Collection:

Cytokines Collection 2025 , Pattern Recognition Receptors and Beyond

Wenjie Zhu, Xiaoyan Xu, Vijayaraj Nagarajan, Jing Guo, Akriti Gupta, Zixuan Peng, Amy Zhang, Jie Liu, Mary J. Mattapallil, Yingyos Jittayasothorn, Reiko Horai, Yasmine Belkaid, Michael G. Constantinides, Anthony J. St Leger, Rachel R. Caspi

J Exp Med (2025) 222 (11): e20251046.

https://doi.org/10.1084/jem.20251046

Published: 11 September 2025

View article titled, TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

Includes: Supplementary data

Journal Articles

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis

J Exp Med (2025) 222 (11): e20241873.

https://doi.org/10.1084/jem.20241873

Published: 03 September 2025

View article titled, A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis

Includes: Supplementary data

Journal Articles

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

In Special Collection:

Pattern Recognition Receptors and Beyond , 2025: The Year in Experimental Medicine

J Exp Med (2025) 222 (11): e20242403.

https://doi.org/10.1084/jem.20242403

Published: 02 September 2025

View article titled, Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

Includes: Supplementary data

Journal Articles

Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

In Special Collection:

Neuroscience Collection 2025

An Ping, Fan Yang, Lingxiao Lu, Xiaotao Zhang, Jianan Lu, Huaming Li, Yichen Gu, Ziyang Jin, Jianmin Zhang, Ligen Shi

J Exp Med (2025) 222 (11): e20241830.

https://doi.org/10.1084/jem.20241830

Published: 25 August 2025

View article titled, Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

Journal Articles

Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages

In Special Collection:

Macrophages and Dendritic Cells in Health and Disease

Henry Yi Cheng, Jiachen Chu, Nathachit Limjunyawong, Jianan Chen, Yingzhi Ye, Kevin Hong Chen, Nicholas Koylass, Shuying Sun, Xinzhong Dong, Zhaozhu Qiu

J Exp Med (2025) 222 (11): e20250312.

https://doi.org/10.1084/jem.20250312

Published: 22 August 2025

View article titled, Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages

Includes: Supplementary data

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Journal

Article Type

Date

Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

A circadian checkpoint relocates neutrophils to minimize injury

XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance

SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases

The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites

SLC7A8 is essential for metabolic fitness and function of Th2 cells

AC/DC: Highway to cell

Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine

Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin

Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity

Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity

CD2 and its ligands are involved in development and activation of MAIT cells

RIPK1 autophosphorylation at S161 mediates cell death and inflammation

RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice

DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages

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