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Journal Articles

Molecular memory of cell fate: A missing dimension of neural implant biocompatibility

Ming Fa Michaelangelo Xie, Rakshaan Rajeev Tebak, Anagh Pathak, Vini Tiwari, Christopher K. Glass
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (9): e20261285.
https://doi.org/10.1084/jem.20261285
Published: 14 August 2026
View article titled, Molecular memory of cell fate: A missing dimension of neural implant biocompatibility
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Journal Articles

CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity

Lauren Evans, Maria Conde Poole, Cenk Celik, Harshita Mishra, Michael J. Pitcher, Anita Grigoriadis, Maria Secrier, Patricia Barral
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (9): e20260216.
https://doi.org/10.1084/jem.20260216
Published: 13 August 2026
View article titled, CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity
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Includes: Supplementary data
Journal Articles

Emerging insights into TL1A biology may guide precision therapy for IBD

Silvia Pires, Wei Yang, Randy S. Longman
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (9): e20260874.
https://doi.org/10.1084/jem.20260874
Published: 06 August 2026
View article titled, Emerging insights into TL1A biology may guide precision therapy for IBD
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Journal Articles

A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair

Lilian Salm, Monica Aida Lopez, Edward Jenkins, Raymond Shim, Oscar Tejada, Bayan Abou Mehrem, Song Huang, Parisa Etemadi Nezhad, Afshin Derakhshani, Woo-Yong Lee, Ysbrand Nusse, Jeffrey B. Mewburn, Nina Noskovicova, Julia Bayer, Mahamud Ur Rashid, Xin Li, Zeynep Baltaci, Daniel Young, Matheus B. Carneiro, Marco Fritzsche, Claudia V. Jakubzick, Nathan C. Peters, Justin F. Deniset, Joel Zindel, Antoine Dufour, Bryan G. Yipp, Jonathon A. Ditlev, Michael L. Dustin, Johnathan Canton, Paul Kubes
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20260410.
https://doi.org/10.1084/jem.20260410
Published: 22 July 2026
View article titled, A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair
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Includes: Supplementary data
Journal Articles

Beyond barrier immunity: IL-17 safeguards the renal epithelium

Michail S. Lionakis
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (9): e20261148.
https://doi.org/10.1084/jem.20261148
Published: 21 July 2026
View article titled, Beyond barrier immunity: IL-17 safeguards the renal epithelium
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Journal Articles

Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Wonseok Choi, Doureradjou Peroumal, Colin T. McLaughlin, Kiyoshi P. Shiomitsu, Gillian A. Moschetta, Kiaan Biswas, Dinubasri Kumariduraivan, Emily Dicesare, Partha S. Biswas
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (9): e20260530.
https://doi.org/10.1084/jem.20260530
Published: 21 July 2026
View article titled, Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection
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Journal Articles

Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM)
Conor Gruber, Meredith Ramba, Bineeta Debnath, Lorenzo Cuollo, Anna-Lena Neehus, Angelica Lee, Sofija Buta, Marta Martin-Fernandez, Jérémie Rosain, Laureline Berteloot, Philippe Drabent, Tom Le Voyer, Camille Soudée, Jessica Peel, Yoann Seeleuthner, Anne Puel, Shen-Ying Zhang, Michael J. Ciancanelli, Carlos A. Arango-Franco, Mélanie Migaud, Marie-Louise Frémond, Florence Renaldo, Odile Boespflug-Tanguy, Imen Dorboz, Beatrice Dubern, Tristan Fonteneau, Nima Parvaneh, Rasol Molatefi, Mohammad Shahrooei, Darragh Duffy, Vincent Bondet, Gillian I. Rice, Yanick J. Crow, Thierry Jo Molina, Nathalie Boddaert, Jean-Laurent Casanova, Veronique Houdouin, Isabelle Melki, Alice Hadchouel, Jacinta Bustamante, Dusan Bogunovic
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20251331.
https://doi.org/10.1084/jem.20251331
Published: 16 July 2026
View article titled, Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)
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Includes: Supplementary data
Journal Articles

Interferon-λ drives renal fibrosis by coordinating epithelial–fibroblast crosstalk

Yunfeng Zhou, Ying Zhang, Miao Zhu, Chenghui Liao, Weie Li, Jie Wang, Tie Chen, Yuan Cheng, Peter Staeheli, Liang Ye
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20251858.
https://doi.org/10.1084/jem.20251858
Published: 06 July 2026
View article titled, Interferon-λ drives renal fibrosis by coordinating epithelial–fibroblast crosstalk
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Includes: Supplementary data
Journal Articles

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis

Amirah Al Jawazneh, Imke Liebold, Stephanie Leyk, Clarissa Lanzloth, Vera Brackrock, Tamara López-López, Sebastian Graute, Irene Aranda-Pardos, Madeleine Hamley, Jonas Bahn, Joerg Heeren, Johann Von Felden, Ansgar W. Lohse, Christoph Schramm, Dorothee Schwinge, Pablo J. Sáez, Noelia A-Gonzalez, Samuel Huber, Thomas Jacobs, Lorenz Adlung, Anna Worthmann, Lidia Bosurgi
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20242079.
https://doi.org/10.1084/jem.20242079
Published: 23 June 2026
View article titled, Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis
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Includes: Supplementary data
Journal Articles

Mechanobiology of inflammation: Pulling the strings of innate immunity

Marcin Krzysztof Maniak, Stephen J. Jenkins, Carsten Gram Hansen
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252269.
https://doi.org/10.1084/jem.20252269
Published: 23 June 2026
View article titled, Mechanobiology of inflammation: Pulling the strings of innate immunity
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Journal Articles

Endothelial cells notch monocytes toward an alveolar macrophage fate

Stijn Verwaerde, Bart N. Lambrecht, Martin Guilliams
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20260831.
https://doi.org/10.1084/jem.20260831
Published: 22 June 2026
View article titled, Endothelial cells notch monocytes toward an alveolar macrophage fate
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Journal Articles

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Hyunu Kim, Simon Grassmann, Wilfred Wong, Nicholas M. Adams, Yuka Kanno, John J. O’Shea, Christina S. Leslie, Inez Rogatsky, Joseph C. Sun
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20250995.
https://doi.org/10.1084/jem.20250995
Published: 18 June 2026
View article titled, Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells
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Journal Articles

Leveraging cDC1 biology and function for enhanced immunotherapy

Ross W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (7): e20241199.
https://doi.org/10.1084/jem.20241199
Published: 10 June 2026
View article titled, Leveraging cDC1 biology and function for enhanced immunotherapy
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Journal Articles

A signal-responsive cooperative transcription factor network determines alveolar macrophage identity

In Special Collection:
JEM Mucosal Immunology 2026
Jorge Mínguez-Martínez, Jesús Porcuna, Laura Casablanca, Manuel J. Gómez, Hooman Aghelpasand, Pontus Höjer, Belén García-Fojeda, Vanessa Núñez, Carlos Torroja, Severin Mühleder, Charlotte Gustafsson, Thierry Fischer, Rui Benedito, Cristina Casals, Robert Månsson, Fátima Sánchez-Cabo, Mercedes Ricote
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20242085.
https://doi.org/10.1084/jem.20242085
Published: 02 June 2026
View article titled, A signal-responsive cooperative transcription factor network determines alveolar macrophage identity
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Includes: Supplementary data
Journal Articles

CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcripts

Megumi Tatematsu, Shunsuke Takasuga, Akane Fuchimukai, Yuumi Kimura, Satoshi Ishii, Ichiro Taniuchi, Kenji Ishiwata, Koichi Ikuta, Veronika Sexl, Gérard Eberl, Shinichiro Sawa, Keiji Kuba, Takashi Ebihara
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20250895.
https://doi.org/10.1084/jem.20250895
Published: 12 May 2026
View article titled, CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcripts
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Includes: Supplementary data
Journal Articles

BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism

In Special Collection:
Inflammation Resolution 2026
Jianye Wang, Ying Wang, Gaoyu Liu, Jinhao Yang, Houjia Hu, Hailong Cao, Shuo Wang, Xuanlin Liu, Jingyi Wu, Meng Yao, Xiaolei Pan, Pan Zhou, Ying Yu, Zuoqing Song, Qiang Liu, Jie Zhou
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20251918.
https://doi.org/10.1084/jem.20251918
Published: 28 April 2026
View article titled, BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism
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Includes: Supplementary data
Journal Articles

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

In Special Collection:
Inflammation Resolution 2026
Jiseon Kim, Joseph R. Dominguez, Seung Hyeon Kim, Zachary White, Jaewon Cho, Jungmin Hwang, Yeonwoo Choi, Soroush Tahmasebi, Teruyuki Sano, Jinki Yeom, Ki-Wook Kim
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20251492.
https://doi.org/10.1084/jem.20251492
Published: 28 April 2026
View article titled, Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection
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Journal Articles

Signals in space: TGF-β defines where and what gut macrophages become

Camille Blériot, Florent Ginhoux
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20260402.
https://doi.org/10.1084/jem.20260402
Published: 21 April 2026
View article titled, Signals in space: TGF-β defines where and what gut macrophages become
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Journal Articles

CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β

In Special Collection:
JEM Mucosal Immunology 2026
Vignesh Jayaraman, Ian E. Prise, Verena Kästele, Sabrina Tamburrano, Kelly Wemyss, Hayley M. Bridgeman, Rufus H. Daw, Patrick Strangward, Alfie Sanderson, Sheena M. Cruickshank, Joanne E. Konkel, Christine Chew, Chengcan Yao, C.J. Anderson, Josef Priller, Barry McColl, David A.D. Munro, Liesbet Martens, Charlotte L. Scott, Martin Guilliams, Antony D. Adamson, John R. Grainger, Tovah N. Shaw
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20240801.
https://doi.org/10.1084/jem.20240801
Published: 21 April 2026
View article titled, CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β
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Includes: Supplementary data
Journal Articles

ILC2s ride the Blimp to fly

Matthew R. Hepworth, Richard K. Grencis
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20260323.
https://doi.org/10.1084/jem.20260323
Published: 09 April 2026
View article titled, ILC2s ride the Blimp to fly
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