Infectious disease and host defense | Page 1 | Search Results | Journal of Experimental Medicine

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Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults

J Exp Med (2026) 223 (10): e20261020.

https://doi.org/10.1084/jem.20261020

Published: 28 September 2026

View article titled, Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults

Journal Articles

Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity

J Exp Med (2026) 223 (10): e20241620.

https://doi.org/10.1084/jem.20241620

Published: 18 September 2026

View article titled, Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity

Includes: Supplementary data

Journal Articles

Upper respiratory tract CD8⁺ tissue-resident memory T cells protect against viral transmission

Sarah E. Michalets, Yixel Soto-Vazquez, Kathryn M. Moore, M. Elliott Williams, Ananya Saha, Ariana Jimenez, Yu-shan Huang, Anice C. Lowen, Christopher D. Scharer, Alison Swaims-Kohlmeier, Rustom Antia, Jacob E. Kohlmeier

J Exp Med (2026) 223 (11): e20252329.

https://doi.org/10.1084/jem.20252329

Published: 10 September 2026

View article titled, Upper respiratory tract CD8+ tissue-resident memory T cells protect against viral transmission

Journal Articles

Vps4B controls caspase-1 dynamics at the ASC speck to drive inflammasome activation

Yanfeng Li, Qingqing Xie, Longjun Li, Rudi Mao, Luyu Yang, Xuanshuo Liu, Chengjiang Gao, Si Ming Man, Xiaoqing Xu, Tao Xu, Xiaopeng Qi

J Exp Med (2026) 223 (10): e20260373.

https://doi.org/10.1084/jem.20260373

Published: 09 September 2026

View article titled, Vps4B controls caspase-1 dynamics at the ASC speck to drive inflammasome activation

Includes: Supplementary data

Journal Articles

Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

J Exp Med (2026) 223 (10): e20252038.

https://doi.org/10.1084/jem.20252038

Published: 04 September 2026

View article titled, Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Includes: Supplementary data

Journal Articles

Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM)

Luciana Conde, Valter Monteiro, Joao C.R. Freitas, Jameson Crandell, Lauren Lawres, Fernanda Tana, Mallery I. Breban, Fahima Akther, Jordan Polster, Abigail Porzucek, Tauyne M. Ramiro, Ana B. de Oliveira, Mauricio L. Nogueira, David R. Martinez, Nathan D. Grubaugh, Pedro R.J. Almeida, Daniela Weiskopf, Mauro M. Teixeira, Carolina Lucas

J Exp Med (2026) 223 (10): e20261126.

https://doi.org/10.1084/jem.20261126

Published: 02 September 2026

View article titled, Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine

Includes: Supplementary data

Journal Articles

Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses

Yamato Sajiki, Satomi Ando, Charles M. Perkins, Yi-Chung Huang, Katie E. Smith, Carolyn M. Doerning, David A. Hildeman, Koichi Araki

J Exp Med (2026) 223 (10): e20252076.

https://doi.org/10.1084/jem.20252076

Published: 31 August 2026

View article titled, Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses

Includes: Supplementary data

Journal Articles

Borrelia burgdorferi disrupts gut barrier functions and microbiota–antibody interactions

Shilpa Sachan, Giang Vu Vi Tran, Kimberly J. Olsen, Heather Kulaga, Anne Day, Hannah P. Savage, Alison W. Rebman, John N. Aucott, Isabel A. Jimenez, Cory F. Brayton, Nicole Baumgarth

J Exp Med (2026) 223 (9): e20252380.

https://doi.org/10.1084/jem.20252380

Published: 24 August 2026

View article titled, Borrelia burgdorferi disrupts gut barrier functions and microbiota–antibody interactions

Includes: Supplementary data

Journal Articles

Mechanisms of antibody-mediated enhancement of immune responses

Melissa Cipolla, Andrew J. MacLean, Brianna Hernandez, Gabriela S. Silva Santos, Leonidas Stamatatos, Anna Gazumyan, Harald Hartweger, Julia Merkenschlager, Stylianos Bournazos, Jeffrey V. Ravetch, Michel C. Nussenzweig

J Exp Med (2026) 223 (9): e20260305.

https://doi.org/10.1084/jem.20260305

Published: 07 August 2026

View article titled, Mechanisms of antibody-mediated enhancement of immune responses

Includes: Supplementary data

Journal Articles

Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted

J Exp Med (2026) 223 (9): e20260846.

https://doi.org/10.1084/jem.20260846

Published: 07 August 2026

View article titled, Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted

Includes: Supplementary data

Journal Articles

SorLA regulates B cell receptor uptake, trafficking, and B cell–mediated immune responses in vivo

Melibea Berzosa, Adam N. McShane, Anna E. Kliszczak, Aure Aflalo, Pratiti Nanda, Yixuan Shen, Manon H. Williams, Fiona Hills, Chloe M. Shepherd, Kevin O. Saunders, S. Munir Alam, Nicola Ternette, Olav Michael Andersen, Persephone Borrow, Dessislava Malinova

J Exp Med (2026) 223 (9): e20252357.

https://doi.org/10.1084/jem.20252357

Published: 04 August 2026

View article titled, SorLA regulates B cell receptor uptake, trafficking, and B cell–mediated immune responses in vivo

Includes: Supplementary data

Journal Articles

Beyond barrier immunity: IL-17 safeguards the renal epithelium

Michail S. Lionakis

J Exp Med (2026) 223 (9): e20261148.

https://doi.org/10.1084/jem.20261148

Published: 21 July 2026

View article titled, Beyond barrier immunity: IL-17 safeguards the renal epithelium

Journal Articles

Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Wonseok Choi, Doureradjou Peroumal, Colin T. McLaughlin, Kiyoshi P. Shiomitsu, Gillian A. Moschetta, Kiaan Biswas, Dinubasri Kumariduraivan, Emily Dicesare, Partha S. Biswas

J Exp Med (2026) 223 (9): e20260530.

https://doi.org/10.1084/jem.20260530

Published: 21 July 2026

View article titled, Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Journal Articles

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Hyunu Kim, Simon Grassmann, Wilfred Wong, Nicholas M. Adams, Yuka Kanno, John J. O’Shea, Christina S. Leslie, Inez Rogatsky, Joseph C. Sun

J Exp Med (2026) 223 (8): e20250995.

https://doi.org/10.1084/jem.20250995

Published: 18 June 2026

View article titled, Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Journal Articles

BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory B cells

Gretchen Harms Pritchard, Akshay T. Krishnamurty, Lauren B. Rodda, Christopher D. Thouvenel, Derek J. Bangs, Courtney E. McDougal, Laila Shehata, David J. Rawlings, Marion Pepper

J Exp Med (2026) 223 (8): e20252336.

https://doi.org/10.1084/jem.20252336

Published: 10 June 2026

View article titled, BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells

Includes: Supplementary data

Journal Articles

Hantavirus disease and the need for pathogenesis-guided therapy

Søren R. Paludan, Sara Cherry

J Exp Med (2026) 223 (7): e20260871.

https://doi.org/10.1084/jem.20260871

Published: 27 May 2026

View article titled, Hantavirus disease and the need for pathogenesis-guided therapy

Journal Articles

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng

J Exp Med (2026) 223 (7): e20252687.

https://doi.org/10.1084/jem.20252687

Published: 26 May 2026

View article titled, Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Includes: Supplementary data

Journal Articles

Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Evan W. Cody, Mehek Ningoo, Isha Monga, Alexander M. Tsankov, Hiromi Muramatsu, Norbert Pardi, Miguel Fribourg, Peter S. Heeger, David Dominguez-Sola

J Exp Med (2026) 223 (7): e20251048.

https://doi.org/10.1084/jem.20251048

Published: 08 May 2026

View article titled, Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Includes: Supplementary data

Journal Articles

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

In Special Collection:

Inflammation Resolution 2026

Jiseon Kim, Joseph R. Dominguez, Seung Hyeon Kim, Zachary White, Jaewon Cho, Jungmin Hwang, Yeonwoo Choi, Soroush Tahmasebi, Teruyuki Sano, Jinki Yeom, Ki-Wook Kim

J Exp Med (2026) 223 (6): e20251492.

https://doi.org/10.1084/jem.20251492

Published: 28 April 2026

View article titled, Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

Journal Articles

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Yufan Zheng, Makheni Jean Pierre, Eduard Ansaldo, Hannah E. Dobson, Olena Kamenyeva, Chinaemerem U. Onyishi, Sarah Douglas, Christopher Febres Aldana, Pinar Engin Zerk, Irini Sereti, Jovany J. Betancourt, Kirsten Nielsen, Erin McCaffery, Eric V. Dang

J Exp Med (2026) 223 (5): e20260208.

https://doi.org/10.1084/jem.20260208

Published: 20 April 2026

View article titled, Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

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Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults

Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity

Upper respiratory tract CD8⁺ tissue-resident memory T cells protect against viral transmission

Vps4B controls caspase-1 dynamics at the ASC speck to drive inflammasome activation

Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine

Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses

Borrelia burgdorferi disrupts gut barrier functions and microbiota–antibody interactions

Mechanisms of antibody-mediated enhancement of immune responses

Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted

SorLA regulates B cell receptor uptake, trafficking, and B cell–mediated immune responses in vivo

Beyond barrier immunity: IL-17 safeguards the renal epithelium

Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory B cells

Hantavirus disease and the need for pathogenesis-guided therapy

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

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