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Mechanisms of antibody-mediated enhancement of immune responses

Melissa Cipolla, Andrew J. MacLean, Brianna Hernandez, Gabriela S. Silva Santos, Leonidas Stamatatos, Anna Gazumyan, Harald Hartweger, Julia Merkenschlager, Stylianos Bournazos, Jeffrey V. Ravetch, Michel C. Nussenzweig

J Exp Med (2026) 223 (9): e20260305.

https://doi.org/10.1084/jem.20260305

Published: 07 August 2026

View article titled, Mechanisms of antibody-mediated enhancement of immune responses

Includes: Supplementary data

Journal Articles

Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted

J Exp Med (2026) 223 (9): e20260846.

https://doi.org/10.1084/jem.20260846

Published: 07 August 2026

View article titled, Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted

Includes: Supplementary data

Journal Articles

SorLA regulates B cell receptor uptake, trafficking, and B cell–mediated immune responses in vivo

Melibea Berzosa, Adam N. McShane, Anna E. Kliszczak, Aure Aflalo, Pratiti Nanda, Yixuan Shen, Manon H. Williams, Fiona Hills, Chloe M. Shepherd, Kevin O. Saunders, S. Munir Alam, Nicola Ternette, Olav Michael Andersen, Persephone Borrow, Dessislava Malinova

J Exp Med (2026) 223 (9): e20252357.

https://doi.org/10.1084/jem.20252357

Published: 04 August 2026

View article titled, SorLA regulates B cell receptor uptake, trafficking, and B cell–mediated immune responses in vivo

Includes: Supplementary data

Journal Articles

Beyond barrier immunity: IL-17 safeguards the renal epithelium

Michail S. Lionakis

J Exp Med (2026) 223 (9): e20261148.

https://doi.org/10.1084/jem.20261148

Published: 21 July 2026

View article titled, Beyond barrier immunity: IL-17 safeguards the renal epithelium

Journal Articles

Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Wonseok Choi, Doureradjou Peroumal, Colin T. McLaughlin, Kiyoshi P. Shiomitsu, Gillian A. Moschetta, Kiaan Biswas, Dinubasri Kumariduraivan, Emily Dicesare, Partha S. Biswas

J Exp Med (2026) 223 (9): e20260530.

https://doi.org/10.1084/jem.20260530

Published: 21 July 2026

View article titled, Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Journal Articles

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Hyunu Kim, Simon Grassmann, Wilfred Wong, Nicholas M. Adams, Yuka Kanno, John J. O’Shea, Christina S. Leslie, Inez Rogatsky, Joseph C. Sun

J Exp Med (2026) 223 (8): e20250995.

https://doi.org/10.1084/jem.20250995

Published: 18 June 2026

View article titled, Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Journal Articles

BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory B cells

Gretchen Harms Pritchard, Akshay T. Krishnamurty, Lauren B. Rodda, Christopher D. Thouvenel, Derek J. Bangs, Courtney E. McDougal, Laila Shehata, David J. Rawlings, Marion Pepper

J Exp Med (2026) 223 (8): e20252336.

https://doi.org/10.1084/jem.20252336

Published: 10 June 2026

View article titled, BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells

Includes: Supplementary data

Journal Articles

Hantavirus disease and the need for pathogenesis-guided therapy

Søren R. Paludan, Sara Cherry

J Exp Med (2026) 223 (7): e20260871.

https://doi.org/10.1084/jem.20260871

Published: 27 May 2026

View article titled, Hantavirus disease and the need for pathogenesis-guided therapy

Journal Articles

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng

J Exp Med (2026) 223 (7): e20252687.

https://doi.org/10.1084/jem.20252687

Published: 26 May 2026

View article titled, Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Includes: Supplementary data

Journal Articles

Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Evan W. Cody, Mehek Ningoo, Isha Monga, Alexander M. Tsankov, Hiromi Muramatsu, Norbert Pardi, Miguel Fribourg, Peter S. Heeger, David Dominguez-Sola

J Exp Med (2026) 223 (7): e20251048.

https://doi.org/10.1084/jem.20251048

Published: 08 May 2026

View article titled, Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Includes: Supplementary data

Journal Articles

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

In Special Collection:

Inflammation Resolution 2026

Jiseon Kim, Joseph R. Dominguez, Seung Hyeon Kim, Zachary White, Jaewon Cho, Jungmin Hwang, Yeonwoo Choi, Soroush Tahmasebi, Teruyuki Sano, Jinki Yeom, Ki-Wook Kim

J Exp Med (2026) 223 (6): e20251492.

https://doi.org/10.1084/jem.20251492

Published: 28 April 2026

View article titled, Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

Journal Articles

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Yufan Zheng, Makheni Jean Pierre, Eduard Ansaldo, Hannah E. Dobson, Olena Kamenyeva, Chinaemerem U. Onyishi, Sarah Douglas, Christopher Febres Aldana, Pinar Engin Zerk, Irini Sereti, Jovany J. Betancourt, Kirsten Nielsen, Erin McCaffery, Eric V. Dang

J Exp Med (2026) 223 (5): e20260208.

https://doi.org/10.1084/jem.20260208

Published: 20 April 2026

View article titled, Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Journal Articles

Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to influenza

In Special Collection:

JEM Clinical Immunology Collection 2026

Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Josue Enriquez, Hannes Axelsson, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angeletti

J Exp Med (2026) 223 (5): e20251793.

https://doi.org/10.1084/jem.20251793

Published: 06 April 2026

View article titled, Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza

Includes: Supplementary data

Journal Articles

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

J Exp Med (2026) 223 (5): e20251796.

https://doi.org/10.1084/jem.20251796

Published: 24 March 2026

View article titled, DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

Includes: Supplementary data

Journal Articles

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Wei-Yao Chin, Ching-Tung Wu, Gunn-Guang Liou, Si-Tse Jiang, Yi-Sheng Cheng, Jr-Shiuan Lin, Betty A. Wu-Hsieh, Shi-Chuen Miaw

J Exp Med (2026) 223 (4): e20250978.

https://doi.org/10.1084/jem.20250978

Published: 12 March 2026

View article titled, Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Includes: Supplementary data

Journal Articles

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

In Special Collection:

Updates on the Immune Responses to Tuberculosis and HIV

J Exp Med (2026) 223 (3): e20251067.

https://doi.org/10.1084/jem.20251067

Published: 05 January 2026

View article titled, Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

Includes: Supplementary data

Journal Articles

ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense

In Special Collection:

Immunology Update Winter 2026 , Innate Immune Signaling in Infection and Disease

Cunzhen Li, Zhen Xiong, Deyuan Kong, Yuwei Xu, Runyuan Wu, Peikang Zhang, Ziqi Xiao, Hui Guo, Ying Du, JinSong Li, Yun Chen, Qiang Zhan, Zusen Fan

J Exp Med (2025) 223 (2): e20251051.

https://doi.org/10.1084/jem.20251051

Published: 26 December 2025

View article titled, ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense

Includes: Supplementary data

Journal Articles

Transcription of HIV-1 is heterogenous among authentic latent CD4⁺ T cell clones

In Special Collection:

Updates on the Immune Responses to Tuberculosis and HIV , JEM Clinical Immunology Collection 2026

Cintia Bittar, Ana Rafaela Teixeira, Thiago Y. Oliveira, Gabriela S. Silva Santos, Klara Lenart, Marcilio Jorge Fumagalli, Georg H.J. Weymar, Anna Kaczynska, Noemi L. Linden, Isabella A.T.M. Ferreira, Marina Caskey, R. Brad Jones, Mila Jankovic, Michel C. Nussenzweig

J Exp Med (2025) 223 (3): e20251584.

https://doi.org/10.1084/jem.20251584

Published: 26 December 2025

View article titled, Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones

Includes: Supplementary data

Journal Articles

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

In Special Collection:

Immunology Update Winter 2026 , JEM Mucosal Immunology 2026

Gabrielle R. LeBlanc, Adam L. Sobel, Jonathan Melamed, Dominic Haas, Eduard Ansaldo, Aiko M. Cirone, Elizabeth Murguia, Michael G. Constantinides

J Exp Med (2025) 223 (3): e20241287.

https://doi.org/10.1084/jem.20241287

Published: 16 December 2025

View article titled, Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

Journal Articles

Does fever drive the evolution of antiviral genes?

In Special Collection:

Innate Immune Signaling in Infection and Disease

Ryan A. Langlois

J Exp Med (2025) 223 (1): e20251747.

https://doi.org/10.1084/jem.20251747

Published: 11 December 2025

View article titled, Does fever drive the evolution of antiviral genes?

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Journal

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Date

Mechanisms of antibody-mediated enhancement of immune responses

Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted

SorLA regulates B cell receptor uptake, trafficking, and B cell–mediated immune responses in vivo

Beyond barrier immunity: IL-17 safeguards the renal epithelium

Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory B cells

Hantavirus disease and the need for pathogenesis-guided therapy

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to influenza

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense

Transcription of HIV-1 is heterogenous among authentic latent CD4⁺ T cell clones

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

Does fever drive the evolution of antiviral genes?

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