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Journal Articles

Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation

Dave Maurice De Sousa, Eric Perkey, Laure Le Corre, Salix Boulet, Daniela Gómez Atria, Anneka Allman, Frédéric Duval, Jean-François Daudelin, Joshua D. Brandstadter, Katlyn Lederer, Sarah Mezrag, Livia Odagiu, Myriam Ennajimi, Marion Sarrias, Hélène Decaluwe, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Ivan Maillard, Nathalie Labrecque
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20231758.
https://doi.org/10.1084/jem.20231758
Published: 20 March 2025
View article titled, Early Notch signals from fibroblastic reticular cells program effector CD8<sup>+</sup> T cell differentiation
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Includes: Supplementary data
Journal Articles

Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design

Kevin Groen, Roger Kuratli, Jannik Enkelmann, Sonja Fernbach, Pedro D. Wendel-Garcia, Willy I. Staiger, Marylène Lejeune, Esther Sauras-Colón, Ferran Roche-Campo, Paraskevas Filippidis, Andri Rauch, Swiss HIV Cohort Study, Alexandra Trkola, Huldrych F. Günthard, Roger D. Kouyos, Silvio D. Brugger, Benjamin G. Hale
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20242039.
https://doi.org/10.1084/jem.20242039
Published: 20 March 2025
View article titled, Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design
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Includes: Supplementary data
Journal Articles

An in-depth look at lung lymphatics

David G. Jackson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20250119.
https://doi.org/10.1084/jem.20250119
Published: 19 March 2025
View article titled, An in-depth look at lung lymphatics
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Journal Articles

Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance

Kerry L. Hilligan, Patricia A. Darrah, Robert A. Seder, Alan Sher
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20240496.
https://doi.org/10.1084/jem.20240496
Published: 18 March 2025
View article titled, Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance
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Journal Articles

Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella

Madeline J. Churchill, Ankit Pandeya, Renate Bauer, Tighe Christopher, Stefanie Krug, Roslyn Honodel, Shuchi Smita, Lindsey Warner, Bridget M. Mooney, Alexis R. Gibson, Patrick S. Mitchell, Elia D. Tait Wojno, Isabella Rauch
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20230803.
https://doi.org/10.1084/jem.20230803
Published: 13 March 2025
View article titled, Enteric tuft cell inflammasome activation drives NKp46<sup>+</sup>ILC3 IL22 via PGD<sub>2</sub> and inhibits <em>Salmonella</em>
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Includes: Supplementary data
Journal Articles

Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes

Andrew W. Simonson, Joseph J. Zeppa, Allison N. Bucsan, Michael C. Chao, Supriya Pokkali, Forrest Hopkins, Michael R. Chase, Andrew J. Vickers, Matthew S. Sutton, Caylin G. Winchell, Amy J. Myers, Cassaundra L. Ameel, Ryan J. Kelly, Ben Krouse, Luke E. Hood, Jiaxiang Li, Chelsea C. Lehman, Megha Kamath, Jaime Tomko, Mark A. Rodgers, Rachel Donlan, Harris Chishti, H. Jacob Borish, Edwin Klein, Charles A. Scanga, Sarah M. Fortune, Philana Ling Lin, Pauline Maiello, Mario Roederer, Patricia A. Darrah, Robert A. Seder, JoAnne L. Flynn
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20241571.
https://doi.org/10.1084/jem.20241571
Published: 06 February 2025
View article titled, Intravenous BCG-mediated protection against tuberculosis requires CD4<sup>+</sup> T cells and CD8α<sup>+</sup> lymphocytes
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Includes: Supplementary data
Journal Articles

RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells

Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, Yun Zhang, Tatjana Reuter, Yuko Ishida, Toshikazu Kondo, Tomoki Chiba, Hiroshi Asahara, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Tsuneyasu Kaisho, Yoichi Furukawa, Eicke Latz, Kohta Nakatani, Yoshihiro Izumi, Yunzhong Nie, Hideki Taniguchi, Kensuke Miyake
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20230647.
https://doi.org/10.1084/jem.20230647
Published: 24 January 2025
View article titled, RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells
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Includes: Supplementary data
Journal Articles

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

Xianbin Tian, Yanni Liu, Kun Zhu, Haoran An, Jie Feng, Linqi Zhang, Jing-Ren Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20240735.
https://doi.org/10.1084/jem.20240735
Published: 24 December 2024
View article titled, Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids
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Includes: Supplementary data
Journal Articles

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

In Special Collection:
Tissue Microenvironment and Immune Memory
Colin Sparano, Darío Solís-Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, Caroline Mussak, Elisa Rallo, Stanislav Dergun, Gioana Litscher, Yishu Xu, Mitchell Bijnen, Christin Friedrich, Melanie Greter, Vanda Juranić Lisnić, Burkhard Becher, Georg Gasteiger, Annette Oxenius, Sonia Tugues
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20240930.
https://doi.org/10.1084/jem.20240930
Published: 18 December 2024
View article titled, Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
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Includes: Supplementary data
Journal Articles

Human DBR1 deficiency impairs stress granule–dependent PKR antiviral immunity

Shuo Ru, Sisi Tang, Hui Xu, Jiahao Yin, Yan Guo, Liuping Song, Zhenyu Jin, Danyel Lee, Yi-Hao Chan, Xingyao Chen, Luke Buerer, William Fairbrother, Weidong Jia, Jean-Laurent Casanova, Shen-Ying Zhang, Daxing Gao
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240010.
https://doi.org/10.1084/jem.20240010
Published: 05 December 2024
View article titled, Human DBR1 deficiency impairs stress granule–dependent PKR antiviral immunity
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Includes: Supplementary data
Journal Articles

Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile

In Special Collection:
Host-Microbe Interactions 2025 , Immunology Update Winter 2025
Tasia D. Kellogg, Simona Ceglia, Benedikt M. Mortzfeld, Tanvi M. Tanna, Abigail L. Zeamer, Matthew R. Mancini, Sage E. Foley, Doyle V. Ward, Shakti K. Bhattarai, Beth A. McCormick, Andrea Reboldi, Vanni Bucci
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20232055.
https://doi.org/10.1084/jem.20232055
Published: 26 November 2024
View article titled, Succinate-producing microbiota drives tuft cell hyperplasia to protect against <em>Clostridioides difficile</em>
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Includes: Supplementary data
Journal Articles

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, COVID-19 Human Genetic Effort, DIAMONDS, EUCLIDS, Michael J. Carter, Paul Wellman, Mark Peters, Rebeca Pérez de Diego, Lindsey Ann Edwards, Christopher Chiu, Mahdad Noursadeghi, Alexandre Bolze, Chisato Shimizu, Myrsini Kaforou, Melissa Shea Hamilton, Jethro A. Herberg, Erica G. Schmitt, Agusti Rodriguez-Palmero, Aurora Pujol, Jihoon Kim, Aurélie Cobat, Laurent Abel, Shen-Ying Zhang, Jean-Laurent Casanova, Taco W. Kuijpers, Jane C. Burns, Michael Levin, Adrian C. Hayday, Vanessa Sancho-Shimizu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e920240699.
https://doi.org/10.1084/jem.20240699
Published: 22 November 2024
View article titled, Heterozygous <em>BTNL8</em> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)
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Includes: Supplementary data
Journal Articles

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

Adrian Gervais, Paul Bastard, Lucy Bizien, Céline Delifer, Pierre Tiberghien, Chaturaka Rodrigo, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Francesca Conti, Irene Cassaniti, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Davide Mileto, Alessandro Mancon, Laurent Abel, Anne Puel, Aurélie Cobat, Charles M. Rice, Dániel Cadar, Jonas Schmidt-Chanasit, Johannes F. Scheid, Jacob E. Lemieux, Eric S. Rosenberg, Marianna Agudelo, Stuart G. Tangye, Alessandro Borghesi, Guillaume André Durand, Emilie Duburcq-Gury, Braulio M. Valencia, Andrew R. Lloyd, Anna Nagy, Margaret M. MacDonald, Yannick Simonin, Shen-Ying Zhang, Jean-Laurent Casanova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240942.
https://doi.org/10.1084/jem.20240942
Published: 01 November 2024
View article titled, Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease
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Journal Articles

MAIT cells: Conserved watchers on the wall

In Special Collection:
Host-Microbe Interactions 2025 , Tissue Microenvironment and Immune Memory , Immunology Update Winter 2025
Lilou Germain, Pablo Veloso, Olivier Lantz, François Legoux
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20232298.
https://doi.org/10.1084/jem.20232298
Published: 24 October 2024
View article titled, MAIT cells: Conserved watchers on the wall
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Journal Articles

Finding NEMO in the thymus

Juan Moises Ocampo-Godinez, Alexandra Y. Kreins
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20241590.
https://doi.org/10.1084/jem.20241590
Published: 21 October 2024
View article titled, Finding NEMO in the thymus
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Journal Articles

Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases

Jérémie Rosain, Tom Le Voyer, Xian Liu, Adrian Gervais, Laura Polivka, Axel Cederholm, Laureline Berteloot, Audrey V. Parent, Alessandra Pescatore, Ezia Spinosa, Snezana Minic, Ana Elisa Kiszewski, Miyuki Tsumura, Chloé Thibault, Maria Esnaola Azcoiti, Jelena Martinovic, Quentin Philippot, Taushif Khan, Astrid Marchal, Bénédicte Charmeteau-De Muylder, Lucy Bizien, Caroline Deswarte, Lillia Hadjem, Marie-Odile Fauvarque, Karim Dorgham, Daniel Eriksson, Emilia Liana Falcone, Mathilde Puel, Sinem Ünal, Amyrath Geraldo, Corentin Le Floc’h, Hailun Li, Sylvie Rheault, Christine Muti, Claire Bobrie-Moyrand, Anne Welfringer-Morin, Ramsay L. Fuleihan, Romain Lévy, Marie Roelens, Liwei Gao, Marie Materna, Silvia Pellegrini, Lorenzo Piemonti, Emilie Catherinot, Jean-Christophe Goffard, Arnaud Fekkar, Aissata Sacko-Sow, Camille Soudée, Soraya Boucherit, Anna-Lena Neehus, Cristina Has, Stefanie Hübner, Géraldine Blanchard-Rohner, Blanca Amador-Borrero, Takanori Utsumi, Maki Taniguchi, Hiroo Tani, Kazushi Izawa, Takahiro Yasumi, Sotaro Kanai, Mélanie Migaud, Mélodie Aubart, Nathalie Lambert, Guy Gorochov, Capucine Picard, Claire Soudais, Anne-Sophie L’Honneur, Flore Rozenberg, Joshua D. Milner, Shen-Ying Zhang, Pierre Vabres, Dusan Trpinac, Nico Marr, Nathalie Boddaert, Isabelle Desguerre, Manolis Pasparakis, Corey N. Miller, Cláudia S. Poziomczyk, Laurent Abel, Satoshi Okada, Emmanuelle Jouanguy, Rémi Cheynier, Qian Zhang, Aurélie Cobat, Vivien Béziat, Bertrand Boisson, Julie Steffann, Francesca Fusco, Matilde Valeria Ursini, Smail Hadj-Rabia, Christine Bodemer, Jacinta Bustamante, Hervé Luche, Anne Puel, Gilles Courtois, Paul Bastard, Nils Landegren, Mark S. Anderson, Jean-Laurent Casanova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231152.
https://doi.org/10.1084/jem.20231152
Published: 01 October 2024
View article titled, Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases
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Includes: Supplementary data
Journal Articles

Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients

In Special Collection:
Multifaceted B Cell Functions and Dysfunctions
Adrian Gervais, Astrid Marchal, Andrea Fortova, Michaela Berankova, Lenka Krbkova, Martina Pychova, Jiri Salat, Shuxiang Zhao, Nacim Kerrouche, Tom Le Voyer, Karin Stiasny, Simon Raffl, Anne Schieber Pachart, Samira Fafi-Kremer, Simon Gravier, Davide F. Robbiani, Laurent Abel, Margaret R. MacDonald, Charles M. Rice, Gaia Weissmann, Tarek Kamal Eldin, Eva Robatscher, Elke Maria Erne, Elisabetta Pagani, Alessandro Borghesi, Anne Puel, Paul Bastard, Aurélie Velay, Martin Martinot, Yves Hansmann, Judith H. Aberle, Daniel Ruzek, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240637.
https://doi.org/10.1084/jem.20240637
Published: 24 September 2024
View article titled, Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients
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Includes: Supplementary data
Journal Articles

Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting

In Special Collection:
Multifaceted B Cell Functions and Dysfunctions , 2024: The Year in Experimental Medicine
Raphaël Jeger-Madiot, Delphine Planas, Isabelle Staropoli, Hippolyte Debarnot, Jérôme Kervevan, Héloïse Mary, Camilla Collina, Barbara F. Fonseca, Rémy Robinot, Stacy Gellenoncourt, Olivier Schwartz, Lorna Ewart, Michael Bscheider, Samy Gobaa, Lisa A. Chakrabarti
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240289.
https://doi.org/10.1084/jem.20240289
Published: 06 September 2024
View article titled, Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting
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Journal Articles

Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies

In Special Collection:
Multifaceted B Cell Functions and Dysfunctions , Cytokines Collection 2024
William O. Hahn, K. Rachael Parks, Mingchao Shen, Gabriel Ozorowski, Holly Janes, Lamar Ballweber-Fleming, Amanda S. Woodward Davis, Chris Duplessis, Mark Tomai, Antu K. Dey, Zachary K. Sagawa, Stephen C. De Rosa, Aaron Seese, Latha Kallur Siddaramaiah, Leonidas Stamatatos, Wen-Hsin Lee, Leigh M. Sewall, Dalton Karlinsey, Hannah L. Turner, Vanessa Rubin, Sarah Furth, Kellie MacPhee, Michael Duff, Lawrence Corey, Michael C. Keefer, Srilatha Edupuganti, Ian Frank, Janine Maenza, Lindsey R. Baden, Ollivier Hyrien, Rogier W. Sanders, John P. Moore, Andrew B. Ward, Georgia D. Tomaras, David C. Montefiori, Nadine Rouphael, M. Juliana McElrath
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240604.
https://doi.org/10.1084/jem.20240604
Published: 05 September 2024
View article titled, Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies
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Includes: Supplementary data
Journal Articles

The partitioning of TCR repertoires by thymic selection

In Special Collection:
Autoimmunity 2024
Wan-Lin Lo, Eric S. Huseby
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230897.
https://doi.org/10.1084/jem.20230897
Published: 21 August 2024
View article titled, The partitioning of TCR repertoires by thymic selection
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