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Journal Articles

The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites

Mohamed R. Abdelaal, Jieru Deng, Mitchell P. McInerney, Emi Ito, Anthony W. Purcell, Sho Yamasaki, Jose A. Villadangos, Hamish E.G. McWilliam, Nicholas A. Gherardin, Jamie Rossjohn, Wael Awad
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250711.
https://doi.org/10.1084/jem.20250711
Published: 26 November 2025
View article titled, The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites
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Includes: Supplementary data
Journal Articles

A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes

Lisa Kurz, Mechthild Lütge, Angelina De Martin, Hung-Wei Cheng, Elina Bugar, Yves Stanossek, Samuel Meili, Joshua D. Brandstadter, Ivan Maillard, Lucas Onder, Burkhard Ludewig
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20242300.
https://doi.org/10.1084/jem.20242300
Published: 26 November 2025
View article titled, A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes
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Includes: Supplementary data
Journal Articles

Correction: Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon

Åsa Johansson, Mahadevan Venkita Subramani, Bahtiyar Yilmaz, Elisabeth E.L. Nyström, Elena Layunta, Liisa Arike, Felix Sommer, Philip Rosenstiel, Lars Vereecke, Louise Mannerås-Holm, Andy Wullaert, Thaher Pelaseyed, Malin E.V. Johansson, George M.H. Birchenough
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e2024159111202025c.
https://doi.org/10.1084/jem.2024159111202025c
Published: 26 November 2025
View article titled, Correction: Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon
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Journal Articles

pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection

Elena Hernández-García, Miguel Galán, Sofía C. Khouili, Elena Moya-Ruiz, Ana Redondo-Urzainqui, Francisco J. Cueto, Saraí Martínez-Cano, Manuel Rodrigo-Tapias, Elena Tomasello, Santos Mañes, Marc Dalod, David Sancho, Salvador Iborra
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250099.
https://doi.org/10.1084/jem.20250099
Published: 25 November 2025
View article titled, pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection
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Journal Articles

SLC7A8 is essential for metabolic fitness and function of Th2 cells

Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Shitong Wu, Patrick Fernandes Rodrigues, Raki Sudan, Yizhou Liu, Haerin Jung, Intelly Lee, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250439.
https://doi.org/10.1084/jem.20250439
Published: 21 November 2025
View article titled, SLC7A8 is essential for metabolic fitness and function of Th2 cells
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Journal Articles

Monogenic disorders of the IRF transcription factors

Mattison P. Stojcic, Pariya Yousefi, Catherine M. Biggs, Stuart E. Turvey
Journal: Journal of Experimental Medicine
Series: Genes and Immunity Focus
J Exp Med (2025) 223 (1): e20250939.
https://doi.org/10.1084/jem.20250939
Published: 21 November 2025
View article titled, Monogenic disorders of the IRF transcription factors
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Journal Articles

AC/DC: Highway to cell

Victor Bosteels, William Stainier, Caetano Reis e Sousa
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20251958.
https://doi.org/10.1084/jem.20251958
Published: 13 November 2025
View article titled, AC/DC: Highway to cell
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Journal Articles

Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy

Yuexiao Tang, Tao Yao, Xin Tian, Xintong Xia, Xingxiao Huang, Zhewen Qin, Zhong Shen, Lin Zhao, Yaping Zhao, Bowen Diao, Yan Ping, Xiaoxiao Zheng, Yonghao Xu, Hui Chen, Tao Qian, Tao Ma, Ben Zhou, Suowen Xu, Qimin Zhou, Yong Liu, Mengle Shao, Wei Chen, Bo Shan, Ying Wu
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e2023139511052025c.
https://doi.org/10.1084/jem.2023139511052025c
Published: 13 November 2025
View article titled, Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy
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Journal Articles

JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis

Radek C. Skoda, Olli Silvennoinen
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20251880.
https://doi.org/10.1084/jem.20251880
Published: 11 November 2025
View article titled, JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis
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Journal Articles

Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine

Hanson Tam, Haolin Shen, Ying Xu, Jinping An, Jason G. Cyster
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250887.
https://doi.org/10.1084/jem.20250887
Published: 10 November 2025
View article titled, Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine
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Journal Articles

Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

Ludivine C. Litzler, Astrid Zahn, Kiersten L. Dionne, Adrien Sprumont, Silvana R. Ferreira, Michael R.F. Slattery, Stephen P. Methot, Anne-Marie Patenaude, Steven Hébert, Nisha Kabir, Poorani Ganesh Subramani, Seolkyoung Jung, Stéphane Richard, Claudia L. Kleinman, Javier M. Di Noia
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e2022038111032025a.
https://doi.org/10.1084/jem.2022038111032025a
Published: 10 November 2025
View article titled, Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice
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Journal Articles

The assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumor immunity

Sonia Cinque, Yvessa Verheyden, Sara Adnane, Alessandro Marino, Sarah Hanache, Roberto Vendramin, Alessandro Cuomo, Joanna Pozniak, Alvaro Cortes Calabuig, Marcella Baldewijns, Sébastien Tabruyn, Oliver Bechter, Maria Francesca Baietti, Elisabetta Groaz, Tiziana Bonaldi, Eleonora Leucci
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20251507.
https://doi.org/10.1084/jem.20251507
Published: 07 November 2025
View article titled, The assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumor immunity
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Includes: Supplementary data
Journal Articles

Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function

Dapeng Chen, Liangliang Wang, Chuangyu Wen, Andras Piffko, Jason Bugno, Xianbin Yu, Pingluan Wang, Fei Ji, Emile Z. Naccasha, Jiaai Wang, Xiaona Huang, Steven J. Chmura, Sean P. Pitroda, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250641.
https://doi.org/10.1084/jem.20250641
Published: 06 November 2025
View article titled, Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function
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Includes: Supplementary data
Journal Articles

Esther Obeng: It's exciting to tackle questions that don't yet have answers

Lucie Van Emmenis
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20252212.
https://doi.org/10.1084/jem.20252212
Published: 05 November 2025
View article titled, Esther Obeng: It's exciting to tackle questions that don't yet have answers
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Journal Articles

Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin

Aline Bauer, Lito Zambounis, Ioannis Kritikos, Almut Lütge, Amélie Sabine, Coraline Heron, Milena Petkova, Costanza Giampietro, Katharina Blatter, Salvatore Daniele Bianco, Daniel Gschwend, Gaetana Restivo, Steven T. Proulx, Mitchell P. Levesque, Nicole Lindenblatt, Edoardo Mazza, Michael Detmar, Epameinondas Gousopoulos, Mark D. Robinson, Tatiana V. Petrova, Cornelia Halin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20242353.
https://doi.org/10.1084/jem.20242353
Published: 04 November 2025
View article titled, Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin
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Includes: Supplementary data
Journal Articles

Xbp1 controls the reparative function of intestinal ILC2s during colitis

Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Yang Liu, Yunjiao Zhai, Bowen Xu, Jiajie Hou, Chunyang Li, Yanbo Yu, Xiaohuan Guo, Ju Qiu, Detian Yuan, Shiyang Li
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250440.
https://doi.org/10.1084/jem.20250440
Published: 30 October 2025
View article titled, Xbp1 controls the reparative function of intestinal ILC2s during colitis
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Includes: Supplementary data
Journal Articles

Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms

Cameron Bissett, Lyn Yong, Alexandra J. Spencer, Fionn Nok Lam Ma, Ethan A. Courchesne, Reshma Koolaparambil Mukesh, Marta Ulaszewska, Alexander Sampson, Marie Lucienne, Reshma Kailath, Susan Morris, Claire Powers, Sandra Belij-Rammerstorfer, Vincent J. Munster, Neeltje van Doremalen, Nicholas M. Provine, Teresa Lambe
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20241529.
https://doi.org/10.1084/jem.20241529
Published: 30 October 2025
View article titled, Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms
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Includes: Supplementary data
Journal Articles

Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans

Marvin Werner, Jonas Holst Wolff, Justin Taft, Thomas Zillinger, Daniëla M. Hinke, Toke S. Barfod, Kerstin De Keukeleere, Franziska Winzig, Bettina Bundgaard, Ryo Narita, Thomas Wisbech Skov, Julie A. Jensen, Sofie E. Jørgensen, Charlotte S. Jørgensen, Morten K. Skouboe, Ria Lassaunière, Joke H. de Boer, Martin R. Jakobsen, Jacob G. Mikkelsen, Dusan Bogunovic, Søren R. Paludan, Renée M. van der Sluis, Trine H. Mogensen
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250492.
https://doi.org/10.1084/jem.20250492
Published: 29 October 2025
View article titled, Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans
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Includes: Supplementary data
Journal Articles

First impressions count in TB

Andrea M. Cooper
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20251753.
https://doi.org/10.1084/jem.20251753
Published: 28 October 2025
View article titled, First impressions count in TB
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Journal Articles

Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

Esmeralda Villavicencio Gonzalez, Huda Y. Zoghbi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20241336.
https://doi.org/10.1084/jem.20241336
Published: 23 October 2025
View article titled, Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle
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