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Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models

J Exp Med (2026) 223 (7): e20250699.

https://doi.org/10.1084/jem.20250699

Published: 26 June 2026

View article titled, Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models

Includes: Supplementary data

Journal Articles

Correction: LCK’ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated

Ahmet Eken, Sara A. Johnson, Serife Erdem, Elena W.Y. Hsieh

J Exp Med (2026) 223 (7): e2024104606082026c.

https://doi.org/10.1084/jem.2024104606082026c

Published: 24 June 2026

View article titled, Correction: LCK’ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated

Journal Articles

Flawed translation triggers oncogenic B–T cell communication

Seren Baygün, Marc Schmidt-Supprian

J Exp Med (2026) 223 (8): e20260912.

https://doi.org/10.1084/jem.20260912

Published: 24 June 2026

View article titled, Flawed translation triggers oncogenic B–T cell communication

Journal Articles

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis

J Exp Med (2026) 223 (7): e20242079.

https://doi.org/10.1084/jem.20242079

Published: 23 June 2026

View article titled, Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis

Includes: Supplementary data

Journal Articles

Mechanobiology of inflammation: Pulling the strings of innate immunity

Marcin Krzysztof Maniak, Stephen J. Jenkins, Carsten Gram Hansen

J Exp Med (2026) 223 (7): e20252269.

https://doi.org/10.1084/jem.20252269

Published: 23 June 2026

View article titled, Mechanobiology of inflammation: Pulling the strings of innate immunity

Journal Articles

UBE2F impedes CD8 T cell memory

Li Zhong, Hua Gu

J Exp Med (2026) 223 (7): e20260995.

https://doi.org/10.1084/jem.20260995

Published: 22 June 2026

View article titled, UBE2F impedes CD8 T cell memory

Journal Articles

Endothelial cells notch monocytes toward an alveolar macrophage fate

Stijn Verwaerde, Bart N. Lambrecht, Martin Guilliams

J Exp Med (2026) 223 (7): e20260831.

https://doi.org/10.1084/jem.20260831

Published: 22 June 2026

View article titled, Endothelial cells notch monocytes toward an alveolar macrophage fate

Journal Articles

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

Marco Ongaro, Romane Thouenon, Isaac Crespo, Alexandre Dumez, Mélanie Charmoy, Eduardo Roman Camacho, Victoria J. Morel, Daniela Cropp, Emma Desponds, Giulio Zanette, Yi-Chuan Wang, Letizia Vergili, Laure Tillé, Inés Di Resta, Marine M. Leblond, Jésus Corria Osorio, Ping-Chih Ho, Werner Held, Grégory Verdeil

J Exp Med (2026) 223 (8): e20252115.

https://doi.org/10.1084/jem.20252115

Published: 22 June 2026

View article titled, The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells

Includes: Supplementary data

Journal Articles

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Hyunu Kim, Simon Grassmann, Wilfred Wong, Nicholas M. Adams, Yuka Kanno, John J. O’Shea, Christina S. Leslie, Inez Rogatsky, Joseph C. Sun

J Exp Med (2026) 223 (8): e20250995.

https://doi.org/10.1084/jem.20250995

Published: 18 June 2026

View article titled, Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Journal Articles

Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Mahsa Zarei, Heng Du, Amin H. Nassar, Rachel E. Yan, Krinio Giannikou, Sneha H. Johnson, Hilaire C. Lam, Elizabeth P. Henske, Yubao Wang, Tinghu Zhang, John Asara, David J. Kwiatkowski

J Exp Med (2026) 223 (7): e2019025105292026r.

https://doi.org/10.1084/jem.2019025105292026r

Published: 12 June 2026

View article titled, Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Journal Articles

Leveraging cDC1 biology and function for enhanced immunotherapy

Ross W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj

J Exp Med (2026) 223 (7): e20241199.

https://doi.org/10.1084/jem.20241199

Published: 10 June 2026

View article titled, Leveraging cDC1 biology and function for enhanced immunotherapy

Journal Articles

BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory B cells

Gretchen Harms Pritchard, Akshay T. Krishnamurty, Lauren B. Rodda, Christopher D. Thouvenel, Derek J. Bangs, Courtney E. McDougal, Laila Shehata, David J. Rawlings, Marion Pepper

J Exp Med (2026) 223 (8): e20252336.

https://doi.org/10.1084/jem.20252336

Published: 10 June 2026

View article titled, BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells

Includes: Supplementary data

Journal Articles

Bidirectional regulation by BACH2 coordinates systemic CXCR5⁻ vs. CXCR5⁺ CD4⁺ T cell differentiation

Andrew R. Schroeder, Fangming Zhu, Xianyou Xia, Hui Hu

J Exp Med (2026) 223 (8): e20251959.

https://doi.org/10.1084/jem.20251959

Published: 08 June 2026

View article titled, Bidirectional regulation by BACH2 coordinates systemic CXCR5− vs. CXCR5+ CD4+ T cell differentiation

Includes: Supplementary data

Journal Articles

eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy

J Exp Med (2026) 223 (8): e20251968.

https://doi.org/10.1084/jem.20251968

Published: 03 June 2026

View article titled, eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy

Includes: Supplementary data

Journal Articles

A signal-responsive cooperative transcription factor network determines alveolar macrophage identity

Jorge Mínguez-Martínez, Jesús Porcuna, Laura Casablanca, Manuel J. Gómez, Hooman Aghelpasand, Pontus Höjer, Belén García-Fojeda, Vanessa Núñez, Carlos Torroja, Severin Mühleder, Charlotte Gustafsson, Thierry Fischer, Rui Benedito, Cristina Casals, Robert Månsson, Fátima Sánchez-Cabo, Mercedes Ricote

J Exp Med (2026) 223 (7): e20242085.

https://doi.org/10.1084/jem.20242085

Published: 02 June 2026

View article titled, A signal-responsive cooperative transcription factor network determines alveolar macrophage identity

Includes: Supplementary data

Journal Articles

Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments

Irena Roci, Jaeryung Kim, Kelly de Korodi, Tania Wyss, Jeremiah Bernier-Latmani, Silvia Arroz-Madeira, Alejandra González-Loyola, Esther Bovay, Nadia Grenningloh, Hans Schoofs, Noo Li Jeon, Costanza Giampietro, Taija Mäkinen, Agnès Noël, Tatiana V. Petrova

J Exp Med (2026) 223 (7): e20250506.

https://doi.org/10.1084/jem.20250506

Published: 01 June 2026

View article titled, Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments

Includes: Supplementary data

Journal Articles

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Marine Bruand, Divyanshu Srivastava, Aaron Petruzzella, Maxime Petit, Samantha Mahfoud, Natalya Katanayeva, Asli Kasapoglu, Camille Landragin, Daniele Tavernari, Eleni Balli, Giovanni Ciriello, Tatiana V. Petrova, Elisa Oricchio

J Exp Med (2026) 223 (7): e20252463.

https://doi.org/10.1084/jem.20252463

Published: 01 June 2026

View article titled, Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Includes: Supplementary data

Journal Articles

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer

J Exp Med (2026) 223 (7): e20241484.

https://doi.org/10.1084/jem.20241484

Published: 28 May 2026

View article titled, A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer

Includes: Supplementary data

Journal Articles

Hantavirus disease and the need for pathogenesis-guided therapy

Søren R. Paludan, Sara Cherry

J Exp Med (2026) 223 (7): e20260871.

https://doi.org/10.1084/jem.20260871

Published: 27 May 2026

View article titled, Hantavirus disease and the need for pathogenesis-guided therapy

Journal Articles

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng

J Exp Med (2026) 223 (7): e20252687.

https://doi.org/10.1084/jem.20252687

Published: 26 May 2026

View article titled, Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Includes: Supplementary data

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Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models

Correction: LCK’ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated

Flawed translation triggers oncogenic B–T cell communication

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis

Mechanobiology of inflammation: Pulling the strings of innate immunity

UBE2F impedes CD8 T cell memory

Endothelial cells notch monocytes toward an alveolar macrophage fate

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Leveraging cDC1 biology and function for enhanced immunotherapy

BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory B cells

Bidirectional regulation by BACH2 coordinates systemic CXCR5⁻ vs. CXCR5⁺ CD4⁺ T cell differentiation

eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy

A signal-responsive cooperative transcription factor network determines alveolar macrophage identity

Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer

Hantavirus disease and the need for pathogenesis-guided therapy

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

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