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TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation

J Exp Med (2026) 223 (5): e20251374.

https://doi.org/10.1084/jem.20251374

Published: 27 March 2026

View article titled, TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation

Includes: Supplementary data

Journal Articles

Targeting Mettl8-Tcf1 axis promotes CD8⁺ T_PEX differentiation and antitumor immunity

Jiaxi Song, Dan Cui, Jiabao Wang, Xuewei Qi, Jiaxin Ma, Qing Liu, Jing Yang, Haoyu Yu, Lilin Ye, Qizhao Huang, Jia Li, Fengyin Li

J Exp Med (2026) 223 (5): e20250424.

https://doi.org/10.1084/jem.20250424

Published: 27 March 2026

View article titled, Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity

Includes: Supplementary data

Journal Articles

Basophils drive the resolution and promote wound healing in adult and aged mice

J Exp Med (2026) 223 (5): e20240764.

https://doi.org/10.1084/jem.20240764

Published: 26 March 2026

View article titled, Basophils drive the resolution and promote wound healing in adult and aged mice

Includes: Supplementary data

Journal Articles

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

Nicholas F. Kuhn, Itzia Zaleta-Linares, Kenneth H. Hu, Tristan Courau, Brittany Davidson, Tammie Tam, Chih-Wei Chu, Maxime J. Kinet, Michael D. Rosenblum, Alexis J. Combes, William A. Nyberg, Justin Eyquem, Matthew F. Krummel

J Exp Med (2026) 223 (5): e20251228.

https://doi.org/10.1084/jem.20251228

Published: 25 March 2026

View article titled, Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

Includes: Supplementary data

Journal Articles

MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

Laureline Wetterwald, Anna Köck, Tania Wyss, Silvia Arroz-Madeira, Borja Prat-Luri, Muriel Jaquet, Benoît Petit, Marie-Catherine Vozenin, Seppo Ylä-Herttuala, Valérie Dutoit, Denis Migliorini, Karin Schaeuble, Cathrin Brisken, Mauro Delorenzi, Amélie Sabine, Tatiana V. Petrova

J Exp Med (2026) 223 (5): e20251497.

https://doi.org/10.1084/jem.20251497

Published: 25 March 2026

View article titled, MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

Includes: Supplementary data

Journal Articles

Who gets the calories? An endothelial checkpoint for fat expansion

M. Luisa Iruela-Arispe

J Exp Med (2026) 223 (5): e20260240.

https://doi.org/10.1084/jem.20260240

Published: 25 March 2026

View article titled, Who gets the calories? An endothelial checkpoint for fat expansion

Journal Articles

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

J Exp Med (2026) 223 (5): e20251796.

https://doi.org/10.1084/jem.20251796

Published: 24 March 2026

View article titled, DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

Includes: Supplementary data

Journal Articles

Rethinking disomy: Autosomal expression bias

Dusan Bogunovic

J Exp Med (2026) 223 (4): e20241044.

https://doi.org/10.1084/jem.20241044

Published: 23 March 2026

View article titled, Rethinking disomy: Autosomal expression bias

Journal Articles

Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6C^highLy6G^low monocytes after stroke

Weijie Chen, Xin Wang, Tingting Huang, Yan Li, Chen Chen, Yueman Zhang, Wanqing Xie, Dan Tang, Qiuyue Fan, Rui Pang, Jiemin Yin, Tim Sparwasser, Zhenghong Wang, Arthur Liesz, Yu Gan, Weifeng Yu, Florent Ginhoux, Peiying Li

J Exp Med (2026) 223 (4): e20242025.

https://doi.org/10.1084/jem.20242025

Published: 18 March 2026

View article titled, Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke

Includes: Supplementary data

Journal Articles

Correction: α-Synuclein modulates tau spreading in mouse brains

Fares Bassil, Emily S. Meymand, Hannah J. Brown, Hong Xu, Timothy O. Cox, Shankar Pattabhiraman, Chantal M. Maghames, Qihui Wu, Bin Zhang, John Q. Trojanowski, Virginia M.-Y. Lee

J Exp Med (2026) 223 (4): e2019219302262026c.

https://doi.org/10.1084/jem.2019219302262026c

Published: 18 March 2026

View article titled, Correction: α-Synuclein modulates tau spreading in mouse brains

Journal Articles

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Wei-Yao Chin, Ching-Tung Wu, Gunn-Guang Liou, Si-Tse Jiang, Yi-Sheng Cheng, Jr-Shiuan Lin, Betty A. Wu-Hsieh, Shi-Chuen Miaw

J Exp Med (2026) 223 (4): e20250978.

https://doi.org/10.1084/jem.20250978

Published: 12 March 2026

View article titled, Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Includes: Supplementary data

Journal Articles

Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA

Chaorui Duan, Luke Buerer, Cory Bowers, Allison J. Taggart, Mara H. O’Brien, Sarah Gunasekera, Chien-Ling Lin, Jing Wang, Yi Zeng, Jonathan P. Staley, Alger M. Fredericks, Sean F. Monaghan, Anastasia Welch, Nathaniel E. Clark, Daxing Gao, Nico Marr, Shen-Ying Zhang, Jean-Laurent Casanova, William G. Fairbrother

J Exp Med (2026) 223 (4): e20250344.

https://doi.org/10.1084/jem.20250344

Published: 12 March 2026

View article titled, Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA

Includes: Supplementary data

Journal Articles

Myeloid diversity in tumors: Shaped by genes, location, and time

Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, María Casanova-Acebes

J Exp Med (2026) 223 (4): e20252267.

https://doi.org/10.1084/jem.20252267

Published: 12 March 2026

View article titled, Myeloid diversity in tumors: Shaped by genes, location, and time

Journal Articles

The STING HAQ haplotype and clinical non-penetrance in COPA syndrome

J Exp Med (2026) 223 (4): e20251470.

https://doi.org/10.1084/jem.20251470

Published: 10 March 2026

View article titled, The STING HAQ haplotype and clinical non-penetrance in COPA syndrome

Journal Articles

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

J Exp Med (2026) 223 (4): e20251761.

https://doi.org/10.1084/jem.20251761

Published: 03 March 2026

View article titled, Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

Includes: Supplementary data

Journal Articles

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

J Exp Med (2026) 223 (4): e20252667.

https://doi.org/10.1084/jem.20252667

Published: 03 March 2026

View article titled, Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

Includes: Supplementary data

Journal Articles

Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens

J Exp Med (2026) 223 (4): e20250959.

https://doi.org/10.1084/jem.20250959

Published: 03 March 2026

View article titled, Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens

Includes: Supplementary data

Journal Articles

NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Nishada S. Ramphal, Xinyuan Liu, Ilaria Palagi, Rebecca Jasser, Alma N. Mohebiany, Matthias Klein, Frederike Westermann, Sinduya Krishnarajah, Tommy Regen, Tobias Bopp, Burkhard Becher, Ari Waisman

J Exp Med (2026) 223 (4): e20242294.

https://doi.org/10.1084/jem.20242294

Published: 27 February 2026

View article titled, NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Includes: Supplementary data

Journal Articles

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation

Okito Hashimoto, Tyler D. Hepler, Aisling Tynan, Alejandro Torres, Jian Hua Li, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan

J Exp Med (2026) 223 (4): e20252000.

https://doi.org/10.1084/jem.20252000

Published: 26 February 2026

View article titled, Central neurons encode interleukin-1β signals and mediate stress-induced inflammation

Journal Articles

Allergic airway reactions rewired by PI3Kδ mutation

Lawrence P. Kane

J Exp Med (2026) 223 (4): e20252509.

https://doi.org/10.1084/jem.20252509

Published: 20 February 2026

View article titled, Allergic airway reactions rewired by PI3Kδ mutation

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TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation

Targeting Mettl8-Tcf1 axis promotes CD8⁺ T_PEX differentiation and antitumor immunity

Basophils drive the resolution and promote wound healing in adult and aged mice

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

Who gets the calories? An endothelial checkpoint for fat expansion

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

Rethinking disomy: Autosomal expression bias

Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6C^highLy6G^low monocytes after stroke

Correction: α-Synuclein modulates tau spreading in mouse brains

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA

Myeloid diversity in tumors: Shaped by genes, location, and time

The STING HAQ haplotype and clinical non-penetrance in COPA syndrome

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens

NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation

Allergic airway reactions rewired by PI3Kδ mutation

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