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Journal Articles

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

In Special Collection:

2018 Nobel Prize Collection

Taku Okazaki, Il-mi Okazaki, Jian Wang, Daisuke Sugiura, Fumio Nakaki, Taku Yoshida, Yu Kato, Sidonia Fagarasan, Masamichi Muramatsu, Tomoo Eto, Kyoji Hioki, Tasuku Honjo

J Exp Med (2011) 208 (2): 395–407.

https://doi.org/10.1084/jem.20100466

Published: 07 February 2011

View article titled, PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

Includes: Supplementary data

Journal Articles

AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

Alexander L. Kovalchuk, Wendy duBois, Elizabeth Mushinski, Nicole E. McNeil, Carsten Hirt, Chen-Feng Qi, Zhaoyang Li, Siegfried Janz, Tasuku Honjo, Masamichi Muramatsu, Thomas Ried, Timothy Behrens, Michael Potter

J Exp Med (2007) 204 (12): 2989–3001.

https://doi.org/10.1084/jem.20070882

Published: 12 November 2007

View article titled, AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

Includes: Supplementary data

Journal Articles

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b^{− / −}Pdcd1^{− / −} mice

Taku Okazaki, Yumi Otaka, Jian Wang, Hiroshi Hiai, Toshiyuki Takai, Jeffrey V. Ravetch, Tasuku Honjo

J Exp Med (2005) 202 (12): 1643–1648.

https://doi.org/10.1084/jem.20051984

Published: 13 December 2005

View article titled, Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b − / − Pdcd1 − / − mice

Journal Articles

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

In Special Collection:

2018 Nobel Prize Collection

Yoshiko Iwai, Seigo Terawaki, Masaya Ikegawa, Taku Okazaki, Tasuku Honjo

J Exp Med (2003) 198 (1): 39–50.

https://doi.org/10.1084/jem.20022235

Published: 07 July 2003

View article titled, PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

Journal Articles

Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection

Yuichi Harada, Masamichi Muramatsu, Toshikatsu Shibata, Tasuku Honjo, Kazumichi Kuroda

J Exp Med (2003) 197 (12): 1779–1785.

https://doi.org/10.1084/jem.20021457

Published: 09 June 2003

View article titled, Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection

Journal Articles

Constitutive Expression of AID Leads to Tumorigenesis

Il-mi Okazaki, Hiroshi Hiai, Naoki Kakazu, Shuichi Yamada, Masamichi Muramatsu, Kazuo Kinoshita, Tasuku Honjo

J Exp Med (2003) 197 (9): 1173–1181.

https://doi.org/10.1084/jem.20030275

Published: 05 May 2003

View article titled, Constitutive Expression of AID Leads to Tumorigenesis

Journal Articles

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

In Special Collection:

2018 Nobel Prize Collection

Shengdian Wang, Jürgen Bajorath, Dallas B. Flies, Haidong Dong, Tasuku Honjo, Lieping Chen

J Exp Med (2003) 197 (9): 1083–1091.

https://doi.org/10.1084/jem.20021752

Published: 28 April 2003

View article titled, Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

Journal Articles

Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice

Norihiko Watanabe, Koichi Ikuta, Sazuku Nisitani, Tsutomu Chiba, Tasuku Honjo

J Exp Med (2002) 196 (1): 141–146.

https://doi.org/10.1084/jem.20011519

Published: 24 June 2002

View article titled, Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice

Journal Articles

DNA Double-Strand Breaks : Prior to but not Sufficient in Targeting Hypermutation

Linda Bross, Masamichi Muramatsu, Kazuo Kinoshita, Tasuku Honjo, Heinz Jacobs

J Exp Med (2002) 195 (9): 1187–1192.

https://doi.org/10.1084/jem.20011749

Published: 06 May 2002

View article titled, DNA Double-Strand Breaks : <subtitle>Prior to but not Sufficient in Targeting Hypermutation </subtitle>

Includes: Supplementary data

Journal Articles

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region : Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation

Hitoshi Nagaoka, Masamichi Muramatsu, Namiko Yamamura, Kazuo Kinoshita, Tasuku Honjo

J Exp Med (2002) 195 (4): 529–534.

https://doi.org/10.1084/jem.20012144

Published: 19 February 2002

View article titled, Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region : <subtitle>Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation </subtitle>

Journal Articles

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription

Chung-Gi Lee, Kazuo Kinoshita, Arulvathani Arudchandran, Susana M. Cerritelli, Robert J. Crouch, Tasuku Honjo

J Exp Med (2001) 194 (3): 365–374.

https://doi.org/10.1084/jem.194.3.365

Published: 06 August 2001

View article titled, Quantitative Regulation of Class Switch Recombination by Switch Region Transcription

Journal Articles

Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination

Yasutoshi Agata, Tomoya Katakai, Sang-Kyu Ye, Manabu Sugai, Hiroyuki Gonda, Tasuku Honjo, Koichi Ikuta, Akira Shimizu

J Exp Med (2001) 193 (7): 873–880.

https://doi.org/10.1084/jem.193.7.873

Published: 02 April 2001

View article titled, Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination

Journal Articles

Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice

Norihiko Watanabe, Koichi Ikuta, Sidonia Fagarasan, Shujiro Yazumi, Tsutomu Chiba, Tasuku Honjo

J Exp Med (2000) 192 (11): 1577–1586.

https://doi.org/10.1084/jem.192.11.1577

Published: 27 November 2000

View article titled, Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice

Journal Articles

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

In Special Collection:

2018 Nobel Prize Collection

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, Karen Bourque, Tatyana Chernova, Hiroyuki Nishimura, Lori J. Fitz, Nelly Malenkovich, Taku Okazaki, Michael C. Byrne, Heidi F. Horton, Lynette Fouser, Laura Carter, Vincent Ling, Michael R. Bowman, Beatriz M. Carreno, Mary Collins, Clive R. Wood, Tasuku Honjo

J Exp Med (2000) 192 (7): 1027–1034.

https://doi.org/10.1084/jem.192.7.1027

Published: 02 October 2000

View article titled, Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Journal Articles

Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System

Sidonia Fagarasan, Reiko Shinkura, Tadashi Kamata, Fumiaki Nogaki, Koichi Ikuta, Kei Tashiro, Tasuku Honjo

J Exp Med (2000) 191 (9): 1477–1486.

https://doi.org/10.1084/jem.191.9.1477

Published: 24 April 2000

View article titled, Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System

Journal Articles

Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III

Liliane Fossati-Jimack, Andreea Ioan-Facsinay, Luc Reininger, Yves Chicheportiche, Norihiko Watanabe, Takashi Saito, Frans M. A. Hofhuis, J. Engelbert Gessner, Carsten Schiller, Reinhold E. Schmidt, Tasuku Honjo, J. Sjef Verbeek, Shozo Izui

J Exp Med (2000) 191 (8): 1293–1302.

https://doi.org/10.1084/jem.191.8.1293

Published: 10 April 2000

View article titled, Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III

Journal Articles

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

Hiroyuki Nishimura, Tasuku Honjo, Nagahiro Minato

J Exp Med (2000) 191 (5): 891–898.

https://doi.org/10.1084/jem.191.5.891

Published: 06 March 2000

View article titled, Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

Journal Articles

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

Norman Garceau, Yoko Kosaka, Sally Masters, John Hambor, Reiko Shinkura, Tasuku Honjo, Randolph J. Noelle

J Exp Med (2000) 191 (2): 381–386.

https://doi.org/10.1084/jem.191.2.381

Published: 17 January 2000

View article titled, Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

Journal Articles

High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia

Liliane Fossati-Jimack, Luc Reininger, Yves Chicheportiche, Raphael Clynes, Jeffrey V. Ravetch, Tasuku Honjo, Shozo Izui

J Exp Med (1999) 190 (11): 1689–1696.

https://doi.org/10.1084/jem.190.11.1689

Published: 06 December 1999

View article titled, High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia

Journal Articles

Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment

Norihiko Watanabe, Sazuku Nisitani, Koichi Ikuta, Misao Suzuki, Tsutomu Chiba, Tasuku Honjo

J Exp Med (1999) 190 (4): 461–470.

https://doi.org/10.1084/jem.190.4.461

Published: 16 August 1999

View article titled, Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment

NARROW

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b^{− / −}Pdcd1^{− / −} mice

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection

Constitutive Expression of AID Leads to Tumorigenesis

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice

DNA Double-Strand Breaks : Prior to but not Sufficient in Targeting Hypermutation

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region : Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription

Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination

Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System

Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia

Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment

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