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Journal Articles

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

Ting Tao, Hui Shi, Meng Wang, Antonio R. Perez-Atayde, Wendy B. London, Alejandro Gutierrez, Bernardo Lemos, Adam D. Durbin, A. Thomas Look

J Exp Med (2020) 217 (10): e20191871.

https://doi.org/10.1084/jem.20191871

Published: 29 July 2020

View article titled, Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

Includes: Supplementary data

Journal Articles

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

In Special Collection:

Hematologic malignancies 2019

J Exp Med (2018) 215 (7): 1929–1945.

https://doi.org/10.1084/jem.20170484

Published: 25 June 2018

View article titled, JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

Includes: Supplementary data

Journal Articles

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

Marc R. Mansour, Takaomi Sanda, Lee N. Lawton, Xiaoyu Li, Taras Kreslavsky, Carl D. Novina, Marjorie Brand, Alejandro Gutierrez, Michelle A. Kelliher, Catriona H.M. Jamieson, Harald von Boehmer, Richard A. Young, A. Thomas Look

J Exp Med (2013) 210 (8): 1545–1557.

https://doi.org/10.1084/jem.20122516

Published: 15 July 2013

View article titled, The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

Journal Articles

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

Alejandro Gutierrez, Ruta Grebliunaite, Hui Feng, Elena Kozakewich, Shizhen Zhu, Feng Guo, Elspeth Payne, Marc Mansour, Suzanne E. Dahlberg, Donna S. Neuberg, Jeroen den Hertog, Edward V. Prochownik, Joseph R. Testa, Marian Harris, John P. Kanki, A. Thomas Look

J Exp Med (2011) 208 (8): 1595–1603.

https://doi.org/10.1084/jem.20101691

Published: 04 July 2011

View article titled, Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

Includes: Supplementary data

Journal Articles

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

Lynn M. Heltemes-Harris, Mark J.L. Willette, Laura B. Ramsey, Yi Hua Qiu, E. Shannon Neeley, Nianxiang Zhang, Deborah A. Thomas, Thearith Koeuth, Emily C. Baechler, Steven M. Kornblau, Michael A. Farrar

J Exp Med (2011) 208 (6): 1135–1149.

https://doi.org/10.1084/jem.20101947

Published: 23 May 2011

View article titled, Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

Includes: Supplementary data

Journal Articles

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL

Xiaoyu Li, Takaomi Sanda, A. Thomas Look, Carl D. Novina, Harald von Boehmer

J Exp Med (2011) 208 (4): 663–675.

https://doi.org/10.1084/jem.20102384

Published: 04 April 2011

View article titled, Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL

Includes: Supplementary data

Journal Articles

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Shan Zha, Craig H. Bassing, Takaomi Sanda, James W. Brush, Harin Patel, Peter H. Goff, Michael M. Murphy, Suprawee Tepsuporn, Richard A. Gatti, A. Thomas Look, Frederick W. Alt

J Exp Med (2010) 207 (7): 1369–1380.

https://doi.org/10.1084/jem.20100285

Published: 21 June 2010

View article titled, ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Includes: Supplementary data

Journal Articles

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Shintaro Kamizono, Gordon S. Duncan, Markus G. Seidel, Akira Morimoto, Koichi Hamada, Gerard Grosveld, Koichi Akashi, Evan F. Lind, Jillian P. Haight, Pamela S. Ohashi, A. Thomas Look, Tak W. Mak

J Exp Med (2009) 206 (13): 2977–2986.

https://doi.org/10.1084/jem.20092176

Published: 07 December 2009

View article titled, Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Includes: Supplementary data

Journal Articles

Alu elements mediate MYB gene tandem duplication in human T-ALL

Jennifer O'Neil, Joelle Tchinda, Alejandro Gutierrez, Lisa Moreau, Richard S. Maser, Kwok-Kin Wong, Wei Li, Keith McKenna, X. Shirley Liu, Bin Feng, Donna Neuberg, Lewis Silverman, Daniel J. DeAngelo, Jeffery L. Kutok, Rodney Rothstein, Ronald A. DePinho, Lynda Chin, Charles Lee, A. Thomas Look

J Exp Med (2007) 204 (13): 3059–3066.

https://doi.org/10.1084/jem.20071637

Published: 10 December 2007

View article titled, Alu elements mediate MYB gene tandem duplication in human T-ALL

Includes: Supplementary data

Journal Articles

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P. Meijerink, Rob Pieters, Giulio Draetta, Rosalie Sears, Bruce E. Clurman, A. Thomas Look

J Exp Med (2007) 204 (8): 1813–1824.

https://doi.org/10.1084/jem.20070876

Published: 23 July 2007

View article titled, FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Journal Articles

Reversal of airway hyperresponsiveness by induction of airway mucosal CD4⁺CD25⁺ regulatory T cells

Deborah H. Strickland, Philip A. Stumbles, Graeme R. Zosky, Lily S. Subrata, Jenny A. Thomas, Debra J. Turner, Peter D. Sly, Patrick G. Holt

J Exp Med (2006) 203 (12): 2649–2660.

https://doi.org/10.1084/jem.20060155

Published: 06 November 2006

View article titled, Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells

Journal Articles

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

Malay Mandal, Christine Borowski, Teresa Palomero, Adolfo A. Ferrando, Philipp Oberdoerffer, Fanyong Meng, Antonio Ruiz-Vela, Maria Ciofani, Juan-Carlos Zuniga-Pflucker, Isabella Screpanti, A. Thomas Look, Stanley J. Korsmeyer, Klaus Rajewsky, Harald von Boehmer, Iannis Aifantis

J Exp Med (2005) 201 (4): 603–614.

https://doi.org/10.1084/jem.20041924

Published: 22 February 2005

View article titled, The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

Journal Articles

CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1

Steven P. Lee, Jill M. Brooks, Hatim Al-Jarrah, Wendy A. Thomas, Tracey A. Haigh, Graham S. Taylor, Sibille Humme, Aloys Schepers, Wolfgang Hammerschmidt, John L. Yates, Alan B. Rickinson, Neil W. Blake

J Exp Med (2004) 199 (10): 1409–1420.

https://doi.org/10.1084/jem.20040121

Published: 17 May 2004

View article titled, CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1

Journal Articles

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma : DC Activation Occurs in the Airway Mucosa but Not in the Lung Parenchyma

Joong C. Huh, Deborah H. Strickland, Frode L. Jahnsen, Debra J. Turner, Jenny A. Thomas, Sylvia Napoli, Iriani Tobagus, Philip A. Stumbles, Peter D. Sly, Patrick G. Holt

J Exp Med (2003) 198 (1): 19–30.

https://doi.org/10.1084/jem.20021328

Published: 30 June 2003

View article titled, Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma : <subtitle>DC Activation Occurs in the Airway Mucosa but Not in the Lung Parenchyma </subtitle>

Includes: Supplementary data

Journal Articles

Protection from Lethal Gram-Positive Infection by Macrophage Scavenger Receptor–Dependent Phagocytosis

Christian A. Thomas, Yongmei Li, Tatsuhiko Kodama, Hiroshi Suzuki, Samuel C. Silverstein, Joseph El Khoury

J Exp Med (2000) 191 (1): 147–156.

https://doi.org/10.1084/jem.191.1.147

Published: 03 January 2000

View article titled, Protection from Lethal Gram-Positive Infection by Macrophage Scavenger Receptor–Dependent Phagocytosis

Journal Articles

Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte–derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H₂O₂

Horst Maxeiner, Jens Husemann, Christian A. Thomas, John D. Loike, Joseph El Khoury, Samuel C. Silverstein

J Exp Med (1998) 188 (12): 2257–2265.

https://doi.org/10.1084/jem.188.12.2257

Published: 21 December 1998

View article titled, Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte–derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H2O2

Journal Articles

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

Philip A. Stumbles, Jennifer A. Thomas, Carolyn L. Pimm, Peter T. Lee, Thierry J. Venaille, Stephen Proksch, Patrick G. Holt

J Exp Med (1998) 188 (11): 2019–2031.

https://doi.org/10.1084/jem.188.11.2019

Published: 07 December 1998

View article titled, Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

Journal Articles

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

Mitsuru Matsumoto, Yang-Xin Fu, Hector Molina, Guangming Huang, Jinho Kim, Dori A. Thomas, Moon H. Nahm, David D. Chaplin

J Exp Med (1997) 186 (12): 1997–2004.

https://doi.org/10.1084/jem.186.12.1997

Published: 15 December 1997

View article titled, Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

Journal Articles

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.

A S McWilliam, D Nelson, J A Thomas, P G Holt

J Exp Med (1994) 179 (4): 1331–1336.

https://doi.org/10.1084/jem.179.4.1331

Published: 01 April 1994

View article titled, Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.

Journal Articles

The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer.

P De Camilli, A Thomas, R Cofiell, F Folli, B Lichte, G Piccolo, H M Meinck, M Austoni, G Fassetta, G Bottazzo

J Exp Med (1993) 178 (6): 2219–2223.

https://doi.org/10.1084/jem.178.6.2219

Published: 01 December 1993

View article titled, The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer.

NARROW

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Alu elements mediate MYB gene tandem duplication in human T-ALL

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Reversal of airway hyperresponsiveness by induction of airway mucosal CD4⁺CD25⁺ regulatory T cells

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma : DC Activation Occurs in the Airway Mucosa but Not in the Lung Parenchyma

Protection from Lethal Gram-Positive Infection by Macrophage Scavenger Receptor–Dependent Phagocytosis

Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte–derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H₂O₂

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.

The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer.

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