Issues

Ley et al. provide a review of the technology and accomplishments of dynamic imaging of myeloid cells in atherosclerosis.

Chapuis et al. demonstrate that the combination of adoptive cellular therapy with CTLA4 blockade induces long-term remission in a melanoma patient resistant to both modalities administered serially and individually.

Kubes et al. show that methicillin-resistant Staphylococcus aureus (MRSA) survive and proliferate inside Kupffer cells. Intracellular MRSA is resistant to neutrophil-killing and antibiotics treatment and, when released into the circulation, can infect other organs.

Antignano, Zaph, and collaborators show that the lysine methyltransferase G9a plays a critical role in determining the developmental programs of group 2 and 3 innate lymphoid cells.

Meuwissen and collaborators define a novel genetic cause of pseudo-TORCH syndrome, which resembles the sequelae of congenital infection and represents a novel type I interferonopathy.

Kubota and colleagues show that neurons sequester VEGF to prune blood vessels during eye development.

Keller et al. describe for the first time human LAT deficiency, which causes severe immune dysregulation with autoimmunity, lymphoproliferation, and progressive immunodeficiency.

Busslinger et al. showed that the transcription factors E2A and E2-2 control the expression of genes required for the development of GC B cells and plasma cells.

Streptozotocin causes T1D by inducing the translocation of intestinal bacteria into pancreatic lymph nodes and driving the development of pathogenic Th1 and Th17 cells through NOD2 receptor.

Nguyen and Ehrenstein reveal that anti-TNF antibodies paradoxically enhance membrane TNF–TNF-RII interactions to increase Foxp3 expression and confer upon T reg cells the ability to suppress Th17 cells in rheumatoid arthritis patients.

Goodnow et al. show that in vaccinated humans, anergic autoreactive B cells can hypermutate the B cell receptor during the immune response and remove binding to self while enhancing binding to the vaccine.

Increased expression of the ER membrane acetyl-CoA transporter AT-1 can cause an autism-like phenotype in mice.

Pikman et al. demonstrate that the mitochondrial enzyme MTHFD2 is a potential therapeutic target in acute myeloid leukemia.

Human babesiosis is a tick-borne multisystem disease, and current treatments have both adverse side effects and a significant rate of drug failure. Lawres et al. report that endochin-like quinolones, in combination with atovaquone, cure experimental babesiosis in immunodeficient mice.

Homeostatic levels of IL-4 are necessary for normal development of memory phenotype CD8⁺ T cells and naive CD8⁺ T cells and for a robust CD8⁺ T cell response to LCMV infection.

Healthy donors exposed to Japanese encephalitis (JE) virus show a CD8⁺ T cell response that cross reacts with other flaviviruses. Patients that recovered from JE show a CD4⁺ T cell response that targets structural proteins of JE virus.

Ngkelo et al. use a mast cell–deficient mouse model to reveal a protective role of mast cells in myocardial infarction, through regulation of the cardiac contractile machinery.