-
Cover Image
Cover Image
ON THE COVER
Reports by Tran et al. and Roberts et al. demonstrate that antitumor therapy targeting fibroblast activation protein (FAP) induces bone marrow toxicity. Ablation of FAP-positive bone marrow cells—either via experimental ablation or attack by FAP-reactive T cells—results in cachexia and anemia. This image shows pancreatic cancer tissue stained for FAP, highlighting tumor stromal fibroblasts (brown) surrounding patches of cancer cells (purple). Cover art by Lewis Long ([email protected]).
See pages 1125 and 1137 - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Review
T cell regulation of natural killer cells
Eric Vivier and colleagues discuss recent publications demonstrating that T reg cell restriction of IL-2 availability regulates NK cell function.
Brief Definitive Report
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Ubiquitination of MHCII molecules on dendritic cells is essential for the development of natural regulatory T cells
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells
Loss of TRAF3 results in reduced TCR signaling and defective up-regulation of T-bet and CD122 in iNKT cells that impairs their proliferation and survival.
Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
RB family genes control T cell production and promote thymic involution through reducing Foxn1 expression in thymic epithelial cells.
CXCR4 promotes B cell egress from Peyer’s patches
Chemokine receptor CXCR4 promotes B cell localization to CXCL12+ perilymphatic zones and egress from Peyer’s patches.
IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction
A new polymorphism near the IL28B locus negatively affects induction of IL28B and exhibits strong predictive value for HCV treatment response and spontaneous resolution.
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
Retinoic acid attenuates colitis and is associated with increased IL-22 production from γδ T cells and innate lymphoid cells and enhanced antimicrobial peptide expression.
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
Transfer of FAP-reactive T cells into mice bearing a variety of subcutaneous tumors mediated limited antitumor effects and induced significant cachexia and lethal bone toxicities
Article
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
Ablation of stromal cells expressing fibroblast activation protein-α (FAP) results in cachexia and anemia, and loss of these cells is seen in transplantable tumor models.
Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
Pancreatic T reg cells control the availability of CD4+ T cell–secreted IL-2 to limit NK cell function.
IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
IL-2–dependent adaptive-innate lymphocyte cross talk tunes NK cell reactivity and is limited by T reg cells.
IL-2–dependent adaptive control of NK cell homeostasis
T reg cells restrain IL-2–mediated expansion of immature CD127+ NK cells.
Differentiation of CD8 memory T cells depends on Foxo1
The transcription factor Foxo1 is required for the differentiation of memory CD8+ T cells, and its absence hinders clearance of secondary infections.
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
Dexamethasone suppresses ER stress in inflammatory bowel disease by promoting correct protein folding and ER-associated degradation.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators
PLA2G2D ameliorates skin inflammation through mobilizing pro-resolving lipid mediators.
Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
Mutating anti–HIV-1 broadly neutralizing antibodies increases their breadth and reduces pathways for viral escape through mutation.
CD47 fusion protein targets CD172a+ cells in Crohn’s disease and dampens the production of IL-1β and TNF
CD172a+ cells producing IL-1β and TNF are increased in inflamed tissues in Crohn’s disease and can be targeted by CD47 fusion protein.
A hemolytic pigment of Group B Streptococcus allows bacterial penetration of human placenta
Group B Streptococcus invades human amniotic epithelial cells using a hemolytic pigment.
