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Editorial

Staying true to our roots

Heather L. Van Epps
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From the Archive

IFNγ: Issuing macrophages a license to kill

Hema Bashyam
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In This Issue

The secret autoreactivity of B cells

Ruth Williams
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Targeting AID

Ruth Williams
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Cell replacement therapy—are MAPCs the answer?

Ruth Williams
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Memory maintenance

Ruth Williams
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Activating autoimmunity

Ruth Williams
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Commentary

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T

Michael S. Neuberger,Cristina Rada
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The antiinflammatory activity of IgG: the intravenous IgG paradox

Falk Nimmerjahn,Jeffrey V. Ravetch
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Brief Definitive Report

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

Frédéric Delbos,Said Aoufouchi,Ahmad Faili,Jean-Claude Weill,Claude-Agnès Reynaud
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A critical role for the autophagy gene Atg5 in T cell survival and proliferation

Heather H. Pua,Ivan Dzhagalov,Mariana Chuck,Noboru Mizushima,You-Wen He
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Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β

Suchita Nadkarni,Claudia Mauri,Michael R. Ehrenstein
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T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Keiji Hirota,Motomu Hashimoto,Hiroyuki Yoshitomi,Satoshi Tanaka,Takashi Nomura,Tomoyuki Yamaguchi,Yoichiro Iwakura,Noriko Sakaguchi,Shimon Sakaguchi
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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

Bin Zhang,Natalie A. Bowerman,Joseph K. Salama,Hank Schmidt,Michael T. Spiotto,Andrea Schietinger,Ping Yu,Yang-Xin Fu,Ralph R. Weichselbaum,Donald A. Rowley,David M. Kranz,Hans Schreiber
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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Katharina Lahl,Christoph Loddenkemper,Cathy Drouin,Jennifer Freyer,Jon Arnason,Gérard Eberl,Alf Hamann,Hermann Wagner,Jochen Huehn,Tim Sparwasser
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Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals

Alejandro V. Villarino,Cristina M. Tato,Jason S. Stumhofer,Zhengju Yao,Yongzhi K. Cui,Lothar Hennighausen,John J. O'Shea,Christopher A. Hunter
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Mechanism of thioamide drug action against tuberculosis and leprosy

Feng Wang,Robert Langley,Gulcin Gulten,Lynn G. Dover,Gurdyal S. Besra,William R. Jacobs, Jr.,James C. Sacchettini
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Article

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells

Catherine Riou,Bader Yassine-Diab,Julien Van grevenynghe,Roland Somogyi,Larry D. Greller,Dominic Gagnon,Sylvain Gimmig,Peter Wilkinson,Yu Shi,Mark J. Cameron,Roberto Campos-Gonzalez,Robert S. Balderas,David Kelvin,Rafick-Pierre Sekaly,Elias K. Haddad
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An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response

Yan Liu,Minghua Zhu,Keigo Nishida,Toshio Hirano,Weiguo Zhang
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Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand

Tomoki Ito,Maria Yang,Yui-Hsi Wang,Roberto Lande,Josh Gregorio,Olivia A Perng,Xiao-Feng Qin,Yong-Jun Liu,Michel Gilliet
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Enhanced mast cell activation in mice deficient in the A2b adenosine receptor

Xiaoyang Hua,Martina Kovarova,Kelly D. Chason,MyTrang Nguyen,Beverly H. Koller,Stephen L. Tilley
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Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells

Marta Serafini,Scott J. Dylla,Masayuki Oki,Yves Heremans,Jakub Tolar,Yuehua Jiang,Shannon M. Buckley,Beatriz Pelacho,Terry C. Burns,Sarah Frommer,Derrick J. Rossi,David Bryder,Angela Panoskaltsis-Mortari,Matthew J. O'Shaughnessy,Molly Nelson-Holte,Gabriel C. Fine,Irving L. Weissman,Bruce R. Blazar,Catherine M. Verfaillie
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Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-γ–mediated pathways

Jianguo Liu,Xiuqin Guan,Xiaojing Ma
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Igκ allelic inclusion is a consequence of receptor editing

Rafael Casellas,Qingzhao Zhang,Nai-Ying Zheng,Melissa D. Mathias,Kenneth Smith,Patrick C. Wilson
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IL-25 regulates Th17 function in autoimmune inflammation

Melanie A. Kleinschek,Alexander M. Owyang,Barbara Joyce-Shaikh,Claire L. Langrish,Yi Chen,Daniel M. Gorman,Wendy M. Blumenschein,Terrill McClanahan,Frank Brombacher,Stephen D. Hurst,Robert A. Kastelein,Daniel J. Cua
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Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

Chen Varol,Limor Landsman,Darin K. Fogg,Liat Greenshtein,Boaz Gildor,Raanan Margalit,Vyacheslav Kalchenko,Frederic Geissmann,Steffen Jung
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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation

Diana Ronai,Maria D. Iglesias-Ussel,Manxia Fan,Ziqiang Li,Alberto Martin,Matthew D. Scharff
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Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

Kristin V. Tarbell,Lucine Petit,Xiaopan Zuo,Priscilla Toy,Xunrong Luo,Amina Mqadmi,Hua Yang,Manikkam Suthanthiran,Svetlana Mojsov,Ralph M. Steinman
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Correction

CORRECTION

Jason DeVoss,Yafei Hou,Kellsey Johannes,Wen Lu,Gregory I. Liou,John Rinn,Howard Chang,Rachel R. Caspi,Lawrence Fong,Mark S. Anderson
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CORRECTION

Suchita Nadkarni,Claudia Mauri,Michael R. Ehrenstein
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