Issues

Cover picture: Syncytia formed by the fusion of two cells expressing either CD4/CXCR4 or HIV-1 envelope glycoprotein complex undergo apoptosis. A critical step of the process leading to apoptosis is mitochondrial membrane permeabilization, leading to the dissipation of the mitochondrial transmembrane potential (top right), translocation of apoptosis-inducing factor from mitochondria to the nucleus (left), and mitochondriocystolic translocation of cytochrome c (bottom right). Nuclear apoptosis can be seen in the three panels as chromatin condensation. See related article in this issue by Ferri et al., pp. 1081-1092.