Issues

Cover picture: Correlation among the level of the microfilament-associated protein profilin, the microfilament organization, and the tumorigenicity of breast cancer cells. Fluorescence images of cultivated cells show the organization of microfilament bundles in a breast cancer tumor cell line (CAL51, top) compared with a clone derived from this line after chromosomal transfer of the profilin gene (CAL/17-5, bottom). Elevated expression of profilin in CAL51 derivatives after chromosomal transfer of the profilin gene or after transfection with the profilin cDNA results in more prominent microfilament bundles than in the parental CAL51 cells, which correlates with an improvement of cell adhesion and loss of tumorigenicity. See related article in this issue by Janke et al., 1675-1686.