ErbB3 regulates endosomal sorting and recycling of Integrin β1 in breast epithelial cells independently of ligand signaling. Its depletion redirects cargo to extracellular vesicles, impairs collective migration, and reveals a novel role of pseudo-RTKs in vesicular trafficking.

Thomas et al. use centroid tracking to provide a live, 8-nm precision map of the actin fusion focus that underlies cell–cell fusion in Schizosaccharomyces pombe. They show that myosin V Myo52 transports the formin Fus1 along Fus1-nucleated actin filaments. This establishes positive feedback that drives actin aster formation and maintains a distal pool of secretory vesicle.

A new study shows that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung cancer cells to chemotherapy, offering a promising strategy to overcome treatment resistance.

Yamasaki et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. Contrary to prevailing views, endogenous NL1 localizes to both excitatory and inhibitory synapses; when NL2/4 are absent or NL1-GARLH4 binding is enforced, NL1/3 assemble with GARLH4–GABA_A receptor complexes, linking neuroligins to inhibitory targeting.

Leikina et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, phosphatidylserine exposure, annexin A5 binding and actin cortex detachment that facilitates osteoclast fusion and, possibly, other cell–cell fusions by promoting membrane deformations and increasing local membrane tension.

Arends et al. show that DUX4-induction of stable intranuclear RNA, including pericentromeric human satellite II (HSATII) repeat RNA, leads to nuclear protein aggregation. HSATII ribonucleoprotein complexes impact RNA processing downstream of DUX4 expression.

The study reveals that newly synthesized integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and adhesion. This targeted secretion rapidly increases integrin availability, giving cells dynamic flexibility to adjust to their environment.