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McLaughlin et al. uncover a Toll-6–directed pathway that acts via the FoxO transcription factor to limit microtubule stability in motoneurons. At the Drosophila neuromuscular junction (NMJ), stable microtubules can be marked by acetylated α-tubulin and often appear as a thin filament running through the center of the presynaptic boutons. However, pathway mutants (pictured here) display an expanded distribution of stable microtubules, as the acetylated α-tubulin (white) fills many of the boutons (blue). McLaughlin et al. reveal that impaired structural plasticity is a novel consequence of elevated MT stability in pathway mutants at the NMJ.Image © 2016 McLaughlin et al.
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