On the cover
Nakajo et al. describe how a protein called EHBP1L1 regulates apical membrane transport by linking the small GTPase Rab8 to the membrane tubulating protein Bin1 and the membrane scission factor dynamin. In small intestinal organoids grown from mice lacking Rab8a and Rab8b, the apical marker DPP4 (red) localizes to the subapical region as well as the apical plasma membrane. Basolateral membranes are marked by Na+/K+ ATPase (green) and nuclei are labeled blue.Image © 2016 Nakajo et al.
See page 297.
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TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
TOPBP1 acts in homologous recombination repair, impacts the response to chemotherapeutic agent olaparib, and exhibits aberrant patterns in subsets of human ovarian carcinomas.
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EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells
The novel protein EHBP1L1 links Rab8 to Bin1and dynamin to regulate apical transport in epithelial cells.
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