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Cover Image
Cover Image
On the cover
Nakajo et al. describe how a protein called EHBP1L1 regulates apical membrane transport by linking the small GTPase Rab8 to the membrane tubulating protein Bin1 and the membrane scission factor dynamin. In small intestinal organoids grown from mice lacking Rab8a and Rab8b, the apical marker DPP4 (red) localizes to the subapical region as well as the apical plasma membrane. Basolateral membranes are marked by Na+/K+ ATPase (green) and nuclei are labeled blue.Image © 2016 Nakajo et al.
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In This Issue
In Focus
Mapping the kinetochore Delta
Researchers question the role of intrakinetochore tension in mitotic progression.
People & Ideas
Needhi Bhalla: Chromosomes do the most amazing things
Bhalla studies the regulation of chromosome synapsis during meiotic prophase.
Review
Report
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
TOPBP1 acts in homologous recombination repair, impacts the response to chemotherapeutic agent olaparib, and exhibits aberrant patterns in subsets of human ovarian carcinomas.
Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA
Microtubule-based motility of peroxisomes is achieved by hitchhiking on early endosomes using the novel endosome-associated linker protein PxdA.
EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells
The novel protein EHBP1L1 links Rab8 to Bin1and dynamin to regulate apical transport in epithelial cells.
Article
Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells
Taxol induces extensive structural reorganization of the mammalian kinetochore; however, this reorganization is not sufficient to maintain a long-term mitotic arrest unless some of the kinetochores completely lose their attachment to microtubules.
Global reorganization of budding yeast chromosome conformation in different physiological conditions
Movement of the GAL locus to the nuclear periphery is part of a large-scale rearrangement of chromosome architecture induced by glucose withdrawal and is regulated by the activities of histone acetyltransferases and histone deacetylases.
Distinct requirements for intra-ER sorting and budding of peroxisomal membrane proteins from the ER
An intra-ER sorting process regulates segregation, packaging, and budding of peroxisomal importomer subcomplexes, thereby preventing their premature assembly at the ER.
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
Adhesion signaling of integrin adhesion complexes (IACs) is sensitive to inhibition of key IAC kinases (FAK and/or Src), but IAC composition is not, demonstrating a separation between signaling and structural contributions of IAC components.
