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    Lelli et al. reveal that, by limiting F-actin growth, class III myosins regulate the early steps of auditory hair bundle shaping necessary for normal hearing. The hair cells of mice lacking myosin IIIa and IIIb form misshapen hair bundles (stereocilia in yellow) and abnormally long actin-filled protrusions (orange). Scanning electron micrograph colorized by J.-M. Panaud (Institut Pasteur).
    Image © 2016 Lelli et al.
    See page 231.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Researchers discover two proteins that help maturing endosomes shed phosphatidylinositide.

People & Ideas

Nance surveys the cell movements that orchestrate early embryogenesis.

Review

Report

Loss of OMA1 in a mouse model of neurodegeneration stabilizes fusion-active L-OPA1, which supports neuronal survival by preventing apoptosis, independent of its effects on cristae morphogenesis.

Article

Ubiquitin modifications of the nuclear pore complex (NPC) control the architectural plasticity of the nuclear basket, contributing to its tethering to the core NPC, with consequences on the cellular response to DNA damage and telomere recombination.

C. elegans SORF-1 and SORF-2 and their mammalian homologs WDR91 and WDR81 maintain appropriate PtdIns3P levels in early-to-late endosome conversion by forming a complex with the Beclin1 subunit of the PI3K complex.

P-cadherin induces polarization and collective cell migration through an increase in the strength and anisotropy of mechanical forces, which is mediated by the P-cadherin/β-PIX/Cdc42 axis.

During Drosophila gastrulation, subapical junctions are repositioned toward the apical surface and, as cortical tension increases, are strengthened in a myosin II–dependent manner, which may reflect a mechanosensitive response of junctional complexes to the tension generated by the activation of myosin.

Analysis of mice deficient for myosin IIIa and myosin IIIb shows that class III myosins limit the elongation of stereocilia and of subsequently regressing microvilli, thus contributing to the early hair bundle shaping.

Tools

Generation of high-contrast and high-signal fluorescent 3D speckles allows fluorescent speckle microscopy to be performed in readily available libraries of cell lines and primary tissues for the measurement of microtubule turnover and sliding.

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